The Global Upstream Bioprocessing Market is estimated to be USD 9.71 Bn in 2023 and is expected to reach USD 17.4 Bn by 2028 growing at a CAGR of 12.37%.The future of bioprocessing lies in complete automation and the development of next-generation techniques, with continuous bioprocessing focusing on high productivity
Upstream bioprocessing refers to the initial stages of biopharmaceutical manufacturing, which involves the cultivation of cells or microorganisms that produce the desired product. This stage involves the growth and maintenance of cells or microorganisms in a controlled environment such as a bioreactor. The cells or microorganisms are cultured in a nutrient-rich environment, allowing them to multiply and produce the desired product.
The market is primarily driven by the High Adoption of Single-Use Upstream Bioprocessing, Increasing Implementation of Process Analytical Technology (PAT), and Growing Application of Biotherapeutics. The demand for biologics has been increasing rapidly in recent years, driven by the growing prevalence of chronic diseases, an aging population, and the need for more targeted and personalized therapies. This has led to an increased demand for upstream bioprocessing technologies to produce these products.
In addition, opportunities such rising application of upstream process tissues engineering is a rapidly growing field that combines engineering principles with biology and medicine to develop functional tissues and organs for regenerative medicine applications. The upstream process of tissue engineering involves the production of cells and biomaterials required for tissue regeneration.
Moreover, there have been significant advancements in bioprocessing technologies, including improvements in cell line development, media optimization, and bioreactor design. These advancements have led to increased efficiency, higher yields, and improved quality of biologics, which has further driven the demand for upstream bioprocessing technologies. However, Expensive Establishing & Maintaining and Biostability Issues restrain the market growth.
- One of the key challenges in upstream bioprocessing is maintaining consistent cell growth and productivity throughout the entire process. Factors such as contamination, genetic instability, and environmental stresses can all impact cell growth and productivity, making it difficult to produce consistent yields. To overcome these challenges, biopharmaceutical companies use a variety of techniques and technologies such as genetic engineering, cell line development, and process optimization.
Market Segmentations
- The Global Upstream Bioprocessing Market is segmented based on Product, Workflow, Use Type, Mode, and Geography.
- By Product, the market is classified into Bags & Containers, Bioreactors & Fermenters, Bioreactors Accessories, Cell Culture Products, and Filters. Bioreactors are vessels that are used for the cultivation of cells and microorganisms, as well as the production of biologics such as vaccines, monoclonal antibodies, and recombinant proteins. Cell culture products include cell lines, cell culture reagents, and other products that are used for cell culture applications. In addition, Filtration systems are used for the purification of biologics produced in bioreactors, including depth filters, membrane filters, and chromatography columns. However, the bioreactors segment is expected to hold the largest market share due to its critical role in the production of biologics.
- By Workflow, the market is classified into Cell Culture, Cell Separation, and Media Preparation. Due to continued technological developments in cell culture systems, such as the creation of micro-bioreactors to promote small-scale bioproduction, the cell culture step is anticipated to be the largest segment in workflow in terms of revenue share during the projection period.
- By Use Type, the market is classified into multi-use upstream bioprocessing involves the use of stainless-steel bioreactors and other equipment that can be reused after being cleaned and sterilized. This traditional approach to bioprocessing has been used for many years and is still widely used in large-scale biologics production. Single-use upstream bioprocessing, on the other hand, involves the use of disposable equipment, such as single-use bioreactors, bags, and filters. This approach has gained popularity in recent years due to its flexibility, scalability, and reduced risk of cross-contamination. However, Due to the extensive use of conventional stainless-steel bioreactors for commercial biomanufacturing, multi-use items accounted for the largest share of the market for upstream bioprocessing.
- By Mode, the market is classified into In-House and Outsourced. The in-house segment includes companies that have their own in-house upstream bioprocessing facilities to produce biologics for their use. Whereas the Outsourcing segment includes companies that outsource their upstream bioprocessing requirements to CMOs or other contract service providers. The in-house segment is expected to hold the largest market share due to the increasing trend of biopharmaceutical companies developing their in-house manufacturing capabilities.
- By Geography, the market is classified into the Americas, Europe, Middle-East & Africa, and Asia-Pacific. North America is expected to hold the largest market share due to the presence of a large number of biopharmaceutical companies in the region and the increasing demand for biologics in the healthcare industry. For example, Jefferson (Philadelphia University + Thomas Jefferson University) announced the creation of the Jefferson Institute for Bioprocessing in February 2019 to train professionals in the industry and engineering students to produce biologics. To carry out this project, Jefferson worked with the National Institute for Bioprocessing Research and Training.
- In addition, The Asia-Pacific region is expected to be the fastest-growing market due to the increasing demand for biologics in emerging economies such as China and India, and the availability of low-cost production facilities. Latin America and the Middle East and Africa are also expected to grow, but at a slower pace, due to the limited penetration of biologics in these regions.
Recent Developments
1. High Purity New England (HPNE) opened a new production plant with a USD 10 Mn investment. The building will house the business's Specialty Manufacturing and Distribution Center and expand its ability to produce single-use products - April 20222. Cytiva and Pall Corporation invested more than USD 300 Mn in single-use technologies, including syringe filters for scientific research and bioreactor bags for cell growth used to create customized medications - July 2021
Company Profiles
The report provides a detailed analysis of the competitors in the market. It covers the financial performance analysis for the publicly listed companies in the market. The report also offers detailed information on the companies' recent development and competitive scenario. Some of the companies covered in this report are, Corning, Inc., Esco Micro Pte. Ltd., PBS Biotech, Inc., Sartorius Ag, Thermo Fisher Scientific, Inc. etc.Countries Studied
- America (Argentina, Brazil, Canada, Chile, Colombia, Mexico, Peru, United States, Rest of Americas)
- Europe (Austria, Belgium, Denmark, Finland, France, Germany, Ireland, Italy, Luxembourg, Netherlands, Norway, Poland, Russia, Spain, Sweden, Switzerland, United Kingdom, Rest of Europe)
- Middle-East and Africa (Egypt, Israel, Nigeria, Qatar, Saudi Arabia, South Africa, United Arab Emirates, Rest of MEA)
- Asia-Pacific (Australia, Bangladesh, China, India, Indonesia, Japan, Malaysia, Philippines, Singapore, South Korea, Sri Lanka, Thailand, Taiwan, Rest of Asia-Pacific)
Competitive Quadrant
The report includes Competitive Quadrant, a proprietary tool to analyze and evaluate the position of companies based on their Industry Position score and Market Performance score. The tool uses various factors for categorizing the players into four categories. Some of these factors considered for analysis are financial performance over the last 3 years, growth strategies, innovation score, new product launches, investments, growth in market share, etc.Ansoff Analysis
- The report presents a detailed Ansoff matrix analysis for the Global Upstream Bioprocessing Market. Ansoff Matrix, also known as Product/Market Expansion Grid, is a strategic tool used to design strategies for the growth of the company. The matrix can be used to evaluate approaches in four strategies viz. Market Development, Market Penetration, Product Development, and Diversification. The matrix is also used for risk analysis to understand the risk involved with each approach.
- The publisher analyses the Global Upstream Bioprocessing Market using the Ansoff Matrix to provide the best approaches a company can take to improve its market position.
- Based on the SWOT analysis conducted on the industry and industry players, the publisher has devised suitable strategies for market growth.
Why buy this report?
- The report offers a comprehensive evaluation of the Global Upstream Bioprocessing Market. The report includes in-depth qualitative analysis, verifiable data from authentic sources, and projections about market size. The projections are calculated using proven research methodologies.
- The research report also provides a detailed market size analysis and projections in volume and value terms. The projections are calculated using verified research methodologies.
- Excel data sheet for the market size will also be provided with the report.
- The report has been compiled through extensive primary and secondary research. The primary research is done through interviews, surveys, and observation of renowned personnel in the industry.
- The report includes an in-depth market analysis using Porter’s 5 forces model, PESTLE Analysis, and the Ansoff Matrix. In addition, the impact of COVID-19 on the market is also featured in the report.
- The report includes the regulatory scenario in the industry, which will help you make a well-informed decision. The report discusses major regulatory bodies and major rules and regulations imposed on this sector across various geographies.
- The report includes Self-Assessment Form, which helps customers evaluate their position in the market compared to their competitors.
- The report offers customized research - tailored uniquely to our customers with a quick turnaround time. We offer a 15% customization option at no extra charge to all our clients for any of our syndicated reports.
Report Highlights:
- A complete analysis of the market, including the parent industry
- Important market dynamics and trends
- Impact Analysis - a comprehensive assessment to confront risk and make strategic & operational decisions to counter the changes in the market environment.
- Market segmentation
- Competitive Analysis: Comparative analysis of competitor
- Historical, current, and projected size of the market based on value and volume
- Market size of the US states
- Market shares and strategies of key players
- Recommendations to companies for strengthening their foothold in the market
Table of Contents
1 Report Description
2 Research Methodology
3 Executive Summary
4 Market Dynamics
5 Market Analysis
6 Global Upstream Bioprocessing Market, By Product
7 Global Upstream Bioprocessing Market, By Workflow
8 Global Upstream Bioprocessing Market, By Use Type
9 Global Upstream Bioprocessing Market, By Mode
10 Americas' Upstream Bioprocessing Market
11 Europe's Upstream Bioprocessing Market
12 Middle East and Africa's Upstream Bioprocessing Market
13 APAC's Upstream Bioprocessing Market
14 Competitive Landscape
15 Company Profiles
16 Appendix
Companies Mentioned
- Applikon Biotechnology
- Boehringer Ingelheim International GmbH
- CellGenix GmbH
- CMC Biologics
- Corning, Inc.
- Danaher Corp.
- Eppendorf Ag
- Esco Micro Pte. Ltd.
- GE Healthcare
- Getinge AB
- High Purity New England
- JM BIOCONNECT
- Lonza Group AG
- Meissner Filtration Products, Inc.
- Merck KGaA
- Patheon
- PBS Biotech, Inc.
- Rentschler Biopharma SE
- Samsung BioLogics
- Sartorius Ag
- Thermo Fisher Scientific, Inc.
- Tornado Spectral Systems
- Waters Corp.
Table Information
Report Attribute | Details |
---|---|
No. of Pages | 129 |
Published | February 2024 |
Forecast Period | 2023 - 2028 |
Estimated Market Value ( USD | $ 9.71 Billion |
Forecasted Market Value ( USD | $ 17.4 Billion |
Compound Annual Growth Rate | 12.3% |
Regions Covered | Global |
No. of Companies Mentioned | 23 |