New edition covering the specialties of hematology, oncology and cellular therapy, now in two volumes
Cancer Consult: Expertise in Clinical Practice, Volume 2: Neoplastic Hematology & Cellular Therapy, Second Edition includes hundreds of answers to practice-based questions covering the new principles of diagnosis, classification, staging, treatment, and outcomes in the rapidly advancing field of cancer. This textbook series also provides expert guidance in the areas of cancer-related uncertainties and controversies, including experience-based discussions. The book’s smaller size allows for easy access during medical rounds. This volume also includes: - Up-to-date clinically relevant information on the very latest topics such as molecular techniques, targeted therapies, immunotherapy, BMT, CAR T-cell therapy and translational cancer research - Sections on ALL, AML, myeloid neoplasms, CLL, Hodgkin’s and Non-Hodgkin’s lymphomas, amongst other topics - Streamlined, engaging content to make finding information easier and less time consuming for the reader - Concise and practical expert perspectives that reference key studies - References to the latest NCCN, ESMO, ASH, ASTCT, EBMT and other national guidelines
With its powerful focus on pragmatic clinical diagnostic, therapeutic and prognostic approaches, Cancer Consult: Expertise in Clinical Practice, Volume 2: Neoplastic Hematology & Cellular Therapy, Second Edition will help keep hematology, oncology and cellular therapy practitioners up-to-date, bridging the gaps between journal and reference literature, conferences, and their existing knowledge base. It also offers clinicians, trainees, and fellows an excellent opportunity to enhance their preparation for the ABIM, hematology and oncology fellowship and recertification exams.
Table of Contents
Editors Volume 2 xii
Preface xiii
Author Bios xv
Acknowledgement xvii
Volume 1: Solid Tumors & Supportive Care
Volume 1 Editors:
Syed A. Abutalib, Maurie Markman, Al B. Benson III, and Hope S. Rugo
Part 1 Acute Lymphoblastic Leukemia in Adults 1
1 Prognostic Markers and Models in Acute Lymphoblastic Leukemia 3
Dieter Hoelzer
2 Acute Lymphoblastic Leukemia - Treatment and Outcomes in B-ALL 11
Vijaya Raj Bhatt, Prajwal Dhakal, and Syed A. Abutalib
3 T Cell Acute Lymphoblastic Leukemia and Acute Lymphoblastic Lymphoma 27
Syed A. Abutalib and Daniel J. DeAngelo
4 Minimal Residual Disease in Acute Lymphoblastic Leukemia 51
Caner Saygin, Sarah Monick, and Wendy Stock
5 Hematopoietic Transplantation and Cellular Therapy in Acute Lymphoblastic Leukemia 63
Yael Morgenstern, Netanel A. Horowitz, and Jacob M. Rowe
Part 2 Acute Myeloid Leukemia in Adults 81
6 Prognosis in Acute Myeloid Leukemia: Beyond Cytogenetics 83
Caner Saygin and Lucy A. Godley
7 Young Adults with Acute Myeloid Leukemia 93
Sangeetha Venugopal and Farhad Ravandi
8 Older Adults with Acute Myeloid Leukemia 103
Mary-Elizabeth Percival and Elihu Estey
9 Acute Promyelocytic Leukemia 113
Eytan M. Stein and Martin S. Tallman
10 Measurable Residual Disease in Acute Myeloid Leukemia 121
Marie Bill and Hans Beier Ommen
11 Hematopoietic Cell Transplantation and Cellular Therapy in Acute Myeloid Leukemia 133
Piyanuch Kongtim and Stefan O. Ciurea
Part 3 Myelodysplastic Syndromes and Familial Myeloid Neoplasms 147
12 Diagnosis of Myelodysplastic Syndromes 149
Jay Yang, Vijendra Singh, Ali Gabali, and Charles A. Schiffer
13 Treatment of Myelodysplastic Syndromes 165
Rami S. Komrokji
14 Hematopoietic Cell Transplantation and Cellular Therapy in Myelodysplastic Syndromes 179
Ibrahim Yakoub-Agha
15 Familial Myeloid Neoplasms - When to Suspect and What to Do? 191
Ryan J. Stubbins, Amy M. Trottier , Simone Feurstein, and Lucy A. Godley
Part 4 Myeloproliferative Neoplasms 211
16 Chronic Myeloid Leukemia: Chronic Phase Disease 213
Jerald P. Radich
17 Chronic Myeloid Leukemia: Advance Phases of the Disease 221
Michael J. Mauro
18 Chronic Myeloid Leukemia: Treatment Safety During Reproductive Age and Pregnancy 229
Michael J. Mauro
19 Chronic Myeloid Leukemia: Cessation of Therapy 235
Anand A. Patel and Richard A. Larson
20 Hematopoietic Cell Transplantation in Chronic Myeloid Leukemia 243
Jerald P. Radich
21 Polycythemia Vera 255
Prithviraj Bose and Srdan Verstovsek
22 Essential Thrombocythemia 265
Paola Guglielmelli and Alessandro Maria Vannucchi
23 Primary Myelofibrosis 275
Douglas Tremblay, Sangeetha Venugopal, John Mascarenhas, and Ruben Mesa
24 Hematopoietic Cell Transplantation and Cellular Therapy in Primary and Post ET/PV Myelofibrosis 287
Jerry Luo, Irum Khan, and Damiano Rondelli
25 Chronic Myelomonocytic Leukemia 305
Mrinal M. Patnaik
26 Eosinophilic Myeloproliferative Disorders 315
Jason Gotlib
Part 5 Chronic Lymphocytic and Other Leukemias 331
27 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 333
Jayastu Senapati, Nitin Jain, and Susan O'Brien
28 Hematopoietic Cell Transplantation and Cellular Therapy in Chronic Lymphocytic Leukemia 345
Ajay Major, Michael R. Bishop, and Peter A. Riedell
29 Prolymphocytic Leukemia 357
Dima El-Sharkawi and Claire Dearden
30 Hairy Cell Leukemia 371
Justin M. Watts and Martin S. Tallman
Part 6 Hodgkin Lymphoma 385
31 Classic Hodgkin Lymphoma 387
Christopher R. D'Angelo, James O. Armitage, and Nancy L. Bartlett
32 Nodular Lymphocyte-Predominant Hodgkin Lymphoma 401
Dennis A. Eichenauer
33 Hematopoietic Cell Transplantation and Cellular Therapy in Hodgkin Lymphoma 408
Narendranath Epperla, Alex F. Herrera, and Matthew Mei
Part 7 Non-Hodgkin's Lymphomas 417
34 Pitfalls in the Diagnosis of Non-Hodgkin's Lymphomas 419
Carmen Barcena and Laurence de Leval
35 Follicular Lymphoma 435
Danielle Wallace, Nancy Torres, and Carla Casulo
36 Mantle Cell Lymphoma 447
Christina Poh and Stephen D. Smith
37 Marginal Zone Lymphoma 455
Erin Mulvey, Wayne Tam, and Peter Martin
38 Hematopoietic Cell Transplantation and Cellular Therapy in Indolent Non-Hodgkin's Lymphomas 471
Karthik Nath and Craig S. Sauter
39 Diffuse Large B Cell Lymphoma 485
Alessia Castellino and Grzegorz S. Nowakowski
40 Hematopoietic Cell Transplantation and Cellular Therapy in Diffuse Large B Cell Lymphoma 499
Shreya Desai, Syed Maaz Tariq, Arjun Patel, Istvan Redei, and Syed A. Abutalib
41 Primary Mediastinal Large B Cell Lymphoma 515
Alessandro Broccoli and Pier Luigi Zinzani
42 Double-Hit and Double-Expressor Lymphomas 525
David A. Russler-Germain and Brad S. Kahl
43 Transformed Lymphoma 539
Frederique St-Pierre and Jane N. Winter
44 Burkitt Lymphoma 555
Mark Roschewski and Wyndham Wilson
45 Primary and Secondary CNS Lymphomas 563
Leon D. Kaulen, Nicholas A. Blondin, Fred H. Hochberg, and Joachim M. Baehring
46 HIV-Associated Lymphoma 579
Elif Yilmaz and Kieron Dunleavy
47 Waldenström's Macroglobulinemia 589
Morie A. Gertz
48 Primary Cutaneous Lymphomas 599
Nicholas A. Trum, Jasmine Zain, Steven T. Rosen, and Christiane Querfeld
49 Mycosis Fungoides and Sézary Syndrome 635
Robert Stuver, Alison Moskowitz, Sarah Noor, and Steven M. Horwitz
50 Peripheral T-Cell Lymphoma 647
Avyakta Kallam and James O. Armitage
Part 8 Plasma Cell Neoplasms and Related Disorders 659
51 Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma 661
Francesco Maura, Dickran Kazandjian, and Ola Landgren
52 Risk Stratification Including Measurable Residual Disease in Multiple Myeloma 673
Charalampos Charalampous and Shaji Kumar
53 Newly Diagnosed Multiple Myeloma: Transplant Eligible 687
Sagar Lonial
54 Newly Diagnosed Multiple Myeloma: Transplant Ineligible 699
Daniele Derudas and Claudio Cerchione
55 Relapsed/Refractory Multiple Myeloma 713
Neha Korde and Saad Z. Usmani
56 Light-chain (AL) Amyloidosis 727
Vaishali Sanchorawala
57 Bispecific T Cell Engager and Cell Based Immune Therapy in Multiple Myeloma 739
Meera Mohan, Parameswaran Hari, and Saurabh Chhabra
Part 9 Special Issues in Neoplastic Hematology and Cellular Therapy 751
58 Treatment of Lymphomas During Pregnancy 753
Kieron Dunleavy, Emanuele Zucca, and Fedro A. Peccatori
59 Complications and Management of CAR T Cell Therapy 767
Radowan A. Elnair and Matthew A. Lunning
60 Acute Graft-versus-Host Disease 781
Aaron Etra, Uroosa Ibrahim, Jacques Azzi, and John E. Levine
61 Chronic Graft-versus-Host Disease 793
Andrew Trunk and Daniel R. Couriel
Index 809
