Bullous Keratopathy - Epidemiology Forecast - 2032

This ‘Bullous Keratopathy - Epidemiology Forecast - 2032' report delivers an in-depth understanding of the Bullous Keratopathy, historical and forecasted epidemiology, and the Bullous keratopathy trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

Bullous Keratopathy Disease Understanding

The term keratopathy comes from the root words Kera, meaning cornea, and pathy, meaning disease; therefore, keratopathy is the disease of the cornea with a vast array of underlying causes and mechanisms. Keratopathy can occur due to an eye condition or systemic conditions. There are several types of keratopathy, including bullous keratopathy.

Bullous keratopathy is a pathological condition in which small vesicles, or bullae, formation occurs in the cornea due to endothelial dysfunction. Initially, there is endothelial trauma, followed by progressive stromal and epithelial edema.

The corneal endothelial cells normally do not undergo mitotic cell division, and cell loss results in permanent loss of function. When endothelial cell counts drop too low, the pump fails to function, and fluid moves anteriorly into the stroma and epithelium. The excess fluid precipitates swelling of the cornea. As fluid accumulates between the basal epithelium cells, blister-like formations form (bullae), and they undergo painful ruptures releasing their fluid content to the surface. These characteristic malformations disrupt vision and create pain sensations. The epithelial edema results in the formation of bullae, hence the name bullous keratopathy. Several causes of bullous keratopathy include Fuchs' endothelial dystrophy, corneal surgery, certain types of eye surgeries, eye trauma, cataract, glaucoma surgery, or corneal transplantation. Studies suggest prolonged contact lens wear can also damage the corneal endothelium and result in bullous keratopathy.

Bullous Keratopathy Diagnosis

Diagnosing bullous keratopathy is primarily clinical, based on history and careful evaluation of risk factors, including a detailed history of previous intraocular surgery, ultrasound biomicroscopy, and slit lamp examination. Visualizing anterior chamber structures may not be feasible due to the presence of thick opaque pannus over the cornea. Anterior segment optical coherence tomography (ASOCT) is an important tool to assess the corneal thickness, the extent of sub-epithelial scarring, and the gross abnormality of Descemet's membrane. Counting a specular count of the endothelial cells and their morphology in the fellow eye determines the diagnosis.

Bullous Keratopathy Epidemiology Perspective

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by the cases of major etiologies of bullous keratopathy, bullous keratopathy cases in major etiologies, total bullous keratopathy cases, gender-specific cases of bullous keratopathy, and bullous keratopathy cases in corneal transplant/keratoplasty in the 7MM covering the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan from 2019 to 2032.

Bullous Keratopathy Detailed Epidemiology Segmentation

• As per the estimates by the publisher, the cases of major etiologies of bullous keratopathy in 2022 were estimated to be approximately 6,538,483, 2,563,799, and 168,671 for FECD diagnosed prevalence, cataract surgery, and glaucoma surgery of bullous keratopathy respectively in the US. These cases are expected to increase by 2032.
• In 2022, the total bullous keratopathy cases in the cataract surgery cohort comprised the majority of cases (49.4%), followed by bullous keratopathy in FECD (42%) in the US. While there were least cases in the bullous keratopathy glaucoma surgery. These cases are expected to increase by 2032 at a CAGR of 0.9% during the study period (2019-2032).
• Among the 7MM, the United States accounted for approximately 41% of the total bullous keratopathy cases in the US, which is expected to increase further during the study period (2019-2032).
• Among the 7MM, Germany accounted for the second-highest total bullous keratopathy cases in 2022, with approximately 25,692 cases. These cases are anticipated to decrease by 2032.
• In 2022, there were approximately 37,044 cases of males and 58,553 cases of females suffering from bullous keratopathy, respectively, in EU4 and the UK. the publisher's estimates these are expected to increase during the study period (2019-2032).
• In Japan, the gender-specific cases of bullous keratopathy were approximately 7,371 males and 10,306 females, respectively, in 2022. The cases are expected to increase by 2032.
• In 2022, the bullous keratopathy cases in corneal transplant/keratoplasty included overall corneal transplant/keratoplasty cases, and bullous keratopathy patients in corneal transplant/keratoplasty were approximately 50,506 and 14,142 cases, respectively, in the US. These numbers are expected to rise during the study period (2019-2032).

Scope of the Report

• The report covers a descriptive overview of bullous keratopathy, explaining its symptoms, grading, pathophysiology, and various diagnostic approaches.
• The report provides insight into the 7MM historical and forecasted patient pool covering the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.
• The report assesses the disease risk and burden of bullous keratopathy.
• The report recognizes the growth opportunities in the 7MM concerning the patient population.
• The report provides the segmentation of the disease epidemiology for the 7MM, cases of major etiologies of bullous keratopathy, bullous keratopathy cases in major etiologies, total bullous keratopathy cases, gender-specific cases of bullous keratopathy, and bullous keratopathy cases in corneal transplant/keratoplasty.

Report Highlights

• Ten years forecast of bullous keratopathy
• The 7MM coverage
• Cases of major etiologies of bullous keratopathy
• Bullous keratopathy cases in major etiologies
• Total bullous keratopathy cases
• Gender-specific cases of bullous keratopathy
• Bullous keratopathy cases in corneal transplant/keratoplasty.

Key Questions Answered

• What are the disease risk and burdens of bullous keratopathy?
• What is the historical bullous keratopathy patient pool in the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan?
• What would be the forecasted patient pool of bullous keratopathy at the 7MM level?
• What will be the growth opportunities across the 7MM concerning the patient population with bullous keratopathy?
• Which country would have the highest prevalent population of bullous keratopathy among the countries mentioned above during the forecast period (2023-2032)?
• At what CAGR is the population expected to grow across the 7MM during the forecast period (2023-2032)?

Reasons to Buy

The bullous keratopathy report will allow the user to:

• Develop business strategies by understanding the trends shaping and driving the 7MM bullous keratopathy epidemiology forecast.
• The bullous keratopathy epidemiology report and model were written and developed by Masters and Ph.D. level epidemiologists.
• The bullous keratopathy epidemiology model developed by the publisher is easy to navigate, interactive with a dashboard, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports the data presented in the report and showcases disease trends over the 10-year forecast period using reputable sources.

Key Assessments

• Patient segmentation
• Disease risk and burden
• Risk of disease by the segmentation
• Factors driving growth in a specific patient population

Geographies Covered

• The United States
• EU4 (Germany, France, Italy, and Spain) and the United Kingdom
• Japan

Study Period: 2019-2032