T Cell Metabolism and Cancer Immunotherapy investigates the cellular regulation of T-cell immunity and tolerance. Within ten chapters, the content not only reveals targets of T cell metabolism as critical determinants of immune regulation, but also uncovers unique therapeutic opportunities to improve immunotherapy through targeting T cell metabolism. This fills a significant gap in the knowledge of scientists working in the field of onco-immunology/immunotherapy, and students learning about T cells, metabolism, immunomodulation, and immunotherapy. Because of the plasticity and potentially unlimited capacity for self-renewal, stem cell-derived T lymphocytes have great potential in the treatment of diseases, including cancer.?Despite great advancement in immunotherapy, such as adoptive T cell transfer-based regimen, the clinical outcomes remain less satisfactory due to a variety of factors that lessen its therapeutic efficacy.?
Table of Contents
1. The role of T Cell Metabolism in Cancer Immunotherapies2. Pancreatic cancer immunotherapy using childhood vaccine recall antigens and Listeria
3. Targeting MyD88 costimulation in cancer immunotherapy
4. T cell-derived IL-27 for cancer immunotherapy
5. Defeating cancer with immunomodulatory bacterial therapeutics
6. Salmonella-based cancer immunotherapy: current progress and prospects?
7. Cancer immunotherapy for hepatocellular carcinoma
8. Integrative targeted therapy for melanoma
9. Controls of memory T cell differentiation
10. Inhibition of the Wnt/�-Catenin Pathway overcomes prostate cancer resistance
Authors
Jianxun Song Professor of Microbial Pathogenies and Immunology,Texas A&M University Health Science Center. Dr. Song is Professor of Microbial Pathogenies and Immunology at Texas A&M University Health Science Center, Bryan, TXIs highly motivated to pursue an academic research career in Microbial Pathogenesis and Immunology. The base of expertise on T cell biology needed to perform the proposed research began to develop while he was a postdoctoral scholar and research scientist from the years 2000-2007 under the mentorship of Dr. Michael Croft at La Jolla Institute for Allergy & Immunology. As a PI on previous university-, foundation- and NIH-funded grants, he laid the groundwork for the proposed research by developing antigen-specific T lymphocytes from pluripotent stem cells.. He offered leadership and administrative skills that were developed during his independence as a mentor of graduate students and postdoctoral scholars.
