TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.
Table of Contents
1. A brief introduction to trp channel biology 2. The crystal structure of trp channels: implications for drug discovery 3.�TRP channel dysfunction in hereditary diseases ("TRP channelopathies") 4. Altered trp channel expression in acquired disease 5.�TRP gene polymorphism and disease risk 6. Targeting trpv1 channels for pain relief 7. Trpa1 antagonists for pain relief 8.�TRP channels and migraine 9. Emerging pain targets: trpm and trpc channels 10. Trp channels in bladder disorders 11.�TRP channels in respiratory diseases 12.�TRP channels: emerging targets in covid and its complications 13.�TRP channels and cerebrovascular diseases 14. Targeting�TRP channels for relief from itch 15.�TRP channels in dermatological disorders 16.�TRP channels in hypertension 17.�TRP channels in diabetes, obesity, and metabolic syndrome 18.�TRP channels cardiovascular disease 19. TRP channels and digestive disease 20.�TRP channels and cancer 21.�TRP channels for anxiety relief and for improving mental health 22.�TRP channels and neurodegenerative disorders 23. Mucolipidosis 24.�TRP channels and renal disease 25.�TRP channels and arthritis 26. TRP channels and thermoregulation: therapeutic opportunities
Authors
Arpad Szallasi Associate Professor position at the 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary. Arpad Szallasi is a leading expert on the roles of TRP channels in health and disease. He was the first to provide a biochemical proof for the existence of the vanilloid (capsaicin) receptor, now known as TRPV1. Currently, he holds an Associate Professor position at the 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.His research focuses on targeting of TRP channels for therapeutic purposes, with special emphasis on pain and inflammation.
Arpad Szallasi obtained his MD degree Summa cum Laude from the Medical University School of Debrecen, Hungary (1984). He received his PhD degree in Pharmacology from the Karolinska Institute, Stockholm, Sweden (1995).
Arpad Szallasi held several research positions both in academia (Karolinska Institute, Washington University, St. Louis, MO) and industry (Menarini Ricerche Sud, Pomezia, Italy) before pursuing a carrier in diagnostic pathology.
Arpad Szallasi is a past President for the New Jersey Association of Blood Bank Professional and a former medical advisor to the American Red Cross.
