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Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration

  • Book

  • May 2024
  • Elsevier Science and Technology
  • ID: 5908618

Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration is a comprehensive reference that covers all vistas of standardization of axon regeneration, as well as all multi-omics and system level data and integration tools. By adopting a translational approach, the book bridges current research in the field to clinical applications, and readers can expect to learn standardization approaches for axon regeneration, multi-omics datasets, different databases, search engines, multiple dataset integrative tools, pathway convergence approaches and tools, outcome and outcome measures that unify bench research with clinical outcome. The axon regeneration from existing neurons in central nervous system (CNS) have become a potential possibility in the last decade. The potential possibility of long-distance axon growth has opened the possibility of re-connectivity of axons of retinal ganglion cell neurons within the lateral geniculate nucleus in the brain. The long-distance axon regeneration and re-connectivity is a promise to restore lost vision in the optic nerve. Further, long-distance regeneration and re-innervation is equally helpful for other fields such as spinal cord injuries.

Table of Contents

1. Historic accounts of neuron regeneration 2. Reagents for neuron regeneration structural studies 3. Assessments for functional regeneration 4. In vitro methods 5. In vivo models and pharmacological reagents 6. Systems biology approaches 7. Application of machine learning and artificial intelligence 8. Standardization approaches 9. Re-connectivity and new approaches 10. Regeneration applicable to other fields 11. Food and drug administration outlook for new treatments in this area 12. Approval processes and clinically relevant aspects 13. Enterprise formation strategies 14. Protocols and miscellaneous topics

Authors

Sanjoy K. Bhattacharya Professor of Ophthalmology, Secondary appointments in Biochemistry and Molecular Biology, Neuroscience, Molecular and Cellular Pharmacology Graduate Programs, University of Miami School of Medicine, University of Miami, Miami, FL, USA. Sanjoy K. Bhattacharya, Ph.D. is a Tenured Professor of Ophthalmology and Research Scientist at the University of Miami Bascom Palmer Eye Institute. He is the founding Director of the Miami Integrative Metabolomics Research Center, the Director of the Ophthalmology Mass Spectrometry Core Facility/Shared Instrument Facility, and the Director of the Graduate Program in Vision Science and Investigative Ophthalmology at Miller School of Medicine. His research adopts a multidisciplinary approach which includes mass spectrometric proteomic and lipidomic approaches to study neurodegenerative diseases, and majorly focus is a group of progressive irreversible blinding diseases collectively called glaucoma and also a group of demyelinating diseases termed multiple sclerosis that frequently is associated with visual impairment preceding neurological deficits.