The book summarizes the role of multiple enzyme targets and strategies to design and develop novel drug candidates for Alzheimer’s disease (AD). It brings together researchers across the globe having varied scientific backgrounds and expertise in a single volume.
The chapters highlight current information scientists have unraveled about the origin, pathogenesis and prevention of AD. The contributions consider both established and emerging drug targets viz. Tau proteins, TREM, and microglia. Topics covered in the book include multi-target anti-Alzheimer's agents, epigenetic modifications, and the role of specific proteins like TMP21 and Tau in AD. A section dedicated to pharmacological treatments discusses the significance of tubulin-modifying enzymes, memantine, and glutamate antagonists. Enzymatic targets for drug discovery are thoroughly examined, focusing on cholinesterase, secretases, and other enzymes. Additionally, the book explores innovative nano-carrier-based drug delivery methods, emphasizing the crucial role of nanotechnology in effective Alzheimer's treatment.
The book aims to inform students and researchers in the field of neuroscience, medicine and pharmacology about current research and biochemical nuances of AD pathogenesis and enzymatic drug targeting strategies.
The chapters highlight current information scientists have unraveled about the origin, pathogenesis and prevention of AD. The contributions consider both established and emerging drug targets viz. Tau proteins, TREM, and microglia. Topics covered in the book include multi-target anti-Alzheimer's agents, epigenetic modifications, and the role of specific proteins like TMP21 and Tau in AD. A section dedicated to pharmacological treatments discusses the significance of tubulin-modifying enzymes, memantine, and glutamate antagonists. Enzymatic targets for drug discovery are thoroughly examined, focusing on cholinesterase, secretases, and other enzymes. Additionally, the book explores innovative nano-carrier-based drug delivery methods, emphasizing the crucial role of nanotechnology in effective Alzheimer's treatment.
The book aims to inform students and researchers in the field of neuroscience, medicine and pharmacology about current research and biochemical nuances of AD pathogenesis and enzymatic drug targeting strategies.
Readership
Students and researchers in the field of neuroscience, medicine and pharmacology.Table of Contents
- Contents
- Foreword
- Preface
- List of Contributors
- Design
- Atukuri Dorababu
- Introduction
- Multi-Target Anti-Alzheimer’S Agents
- Tacrine-Heterocycle Hybrids
- Tacrine - Non-Heterocycle Hybrids
- Cholinesterase Inhibitors
- Tacrine-Heterocycle Based Che Inhibitors
- Tacrine-Non-Heterocycle-Based Derivatives
- Discussion and Conclusion
- References
- Divya Adiga, Sangavi Eswaran, S. Sriharikrishnaa, Nadeem G. Khan, Shama Prasada
- Kabekkodu and Dileep Kumar
- Introduction
- Alzheimer’S Disease (Ad)
- Role of Epigenetic Modifications in Ad
- Dna Methylation
- Hydroxy-Methylation
- Mitochondrial Dna Methylation
- Histone Modifications
- Non Coding Rnas (Ncrnas)
- Long-Non Coding Rnas (Lncrnas) in Ad Pathogenesis
- Role of Micrornas in Ad
- Epigenetic Therapy for Ad
- Demethylating Agents
- Hdac Inhibitors
- Non Coding Rnas as Therapy Targets
- Conclusion
- References
- Effective Treatment Approach
- Dipanjan Karati and Dileep Kumar
- Introduction
- Pathogenesis of Alzheimer’S Disease
- Structure of the Amyloid Beta Peptide
- Non-Amyloidogenic Pathway
- Amyloidogenic Pathway
- The Molecular Arrangement of Tmp21
- Nfat and Alzheimer’S Disease
- Outline of App Processing and Formation of Aβ
- Regulation of Tmp21 Expression
- Aberrant Expression of Tmp21 Promotes Aβ Generation
- Promising Effects of Downregulated Tmp21 in Tau Phosphorylation And
- Neurodegeneration
- Tmp21’S Role in Ad
- Gsk3 in Alzheimer’S Disease
- Conclusion
- Acknowledgement
- References
- Alzheimer's Disease: Old Perspective With a New Angle
- Shweta Shrivastava, Ayush Kumar, Manish Kumar Jeengar and Chandraprabha
- Sahu
- Introduction
- Pathophysiology
- Amyloid and Tau Hypotheses in Ad
- Inflammation and Mitochondrial Dysfunction
- Cholinergic Hypothesis
- Pharmacological Treatment
- Acetylcholinesterase Inhibitors
- Nmda Antagonists
- Secretases Inhibitors
- Glycogen Synthase Kinase Inhibitors
- Structure of Microtubule
- Tubulin Modifying Enzymes as a Therapeutic Target for Ad
- Conclusion
- References
- Alzheimer's Disease: Current Updates
- Rakesh Kore, Priya Tiwari, Vijay K Patel, Ekta Shirbhate, Ravichandran Veerasamy, Achal
- Mishra and Harish Rajak
- Introduction
- Pathophysiology of Ad
- Genes Involved in Alzheimer’S Disease
- Memantine
- Mode of Action of Memantine
- Pharmacokinetics of Memantine
- Side Effects of Memantine
- Conclusion
- List of Abbreviations
- References
- Disease
- Ahmet Ozan Ozgen and Ozan Emre Eyupoglu
- Introduction
- Enzymatic Targets in Clinical Use
- Cholinesterase
- Enzymatic Targets in Clinical and Preclinical Studies
- Secretases
- Beta-Amyloid Degrading Enzymes
- Protein Deacetylases
- Phosphodiesterases
- Kinases
- Caspases
- Others
- Conclusion
- References
- Disease
- Sonal Dubey and Mahesh Ar
- Introduction
- Tau Structure
- Tau and Alzheimer’S Disease
- Tau-Targeted Therapies
- Tau-Aggregation
- Methylthioninium Chloride
- Curcumin
- Resveratrol
- Purpurin
- Ginseng
- Metal Nickel
- Folic Acid
- Tau Phosphorylation
- Glycogen Synthase Kinase 3Β
- Cyclin-Dependent Kinase 5
- Thousand-And-One Amino Acid Kinases
- Tau Acetylation
- Tau Ubiquitination
- O-Glcn-Acylation
- Conclusion
- References
- Approaches for the Effective Treatment of Alzheimer’S Disease
- Yogita Kumari, Khushboo Raj and Pankaj Kumar Singh
- Introduction
- Pathophysiology of Ad
- Blood-Brain Barrier
- Mechanism of the Blood-Brain Barrier
- Blood-Brain Barrier Breakdown and Mechanism of Disease
- Drug Transport to Barrier and Targeting Mechanism
- Diagnosis and Treatment of Ad
- Nanotechnology and Its Importance
- Polymeric Nanoparticles
- Nanogels
- Nano Lipid Carrier
- Liposome
- Target Specific Nanoparticles
- Solid Lipid Nanoparticles
- Nanoemulsion
- Targeted Nps for the Treatment of Ad
- Desirable Structural and Physicochemical Properties of Brain-Targeted Nanoparticles
Author
- Dileep Kumar
- Prashant Tiwari
