Hematopathology. Edition No. 3

Table of Contents

Part I: TECHNICAL ASPECTS 1. Processing of the Lymph Node Biopsy Specimen 2. Fine Needle Aspiration of Lymph Nodes 3. Collection, Processing, and Examination of Bone Marrow Specimens 4. Immunohistochemistry for the Hematopathology Laboratory 5. Flow Cytometry 6. Molecular Diagnosis in Hematopathology 7. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them

Part II: NORMAL and REACTIVE CONDTIONS of HEMATOPOIETIC TISSUES

8. Normal Lymphoid Organs and Tissues 9. The Reactive Lymphadenopathies 10. The Normal Bone Marrow 11. Evaluation of Anemia, Leukopenia, and Thrombocytopenia 12. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders

Part III: LYMPHOID NEOPLASMS

13. Principles of Classification of Lymphoid Neoplasms

Section 1: Mature B-Cell Neoplasms

14. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and B-Cell Prolymphocytic Leukemia 15. Lymphoplasmacytic Lymphoma and Waldenstr�m Macroglobulinemia 16. Hairy Cell Leukemia 17. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen 18. Follicular Lymphoma 19. Extranodal Marginal Zone Lymphoma: MALT Lymphoma 20. Primary Cutaneous B-Cell Lymphomas 21. Nodal Marginal Zone Lymphoma 22. Mantle Cell Lymphoma 23. Diffuse Large B-Cell Lymphoma 24. Burkitt Lymphoma and its Mimics 25. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma 26. Plasma Cell Neoplasms 27. Nodular Lymphocyte-Predominant Hodgkin's Lymphoma 28. Classical Hodgkin's Lymphoma and Related Lesions 29. Virally Associated B-Cell Lymphoproliferative Disease

Section 2: MATURE T-CELL AND NK-CELL NEOPLASMS

30. Virally Associated T-Cell and NK-Cell Neoplasms 31. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations 32. T-Cell Prolymphocytic Leukemia 33. Adult T-Cell Leukemia/Lymphoma 34. Hepatosplenic T-Cell Lymphoma 35. Peripheral T-Cell Lymphoma, Not Otherwise Specified 36. Angioimmunoblastic T-Cell Lymphoma 37. Anaplastic Large-Cell Lymphoma, ALK Positive and ALK Negative 38. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas 39. Mycosis Fungoides and S�zary Syndrome 40. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders 41. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes

Section 3: Precursor B- and T-Cell Neoplasms

42. Precursor B- and T-Cell Neoplasms 43. Acute Leukemias of Ambiguous Lineage

Part IV: MYELOID NEOPLASMS

44. Principles of Classification of Myeloid Neoplasms 45. The Myelodysplastic Syndromes 46. Acute Myeloid Leukemia 47. Myeloproliferative Neoplasms 48. Myelodysplastic/Myeloproliferative Neoplasms 49. Mastocytosis 50. Eosinophilia and Chronic Eosinophilic Leukemia, Including Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB, FGFR1, or JAK2 51. Blastic Plasmacytoid Dendritic Cell Neoplasm

Part V: HISTIOCYTIC PROLIFERATIONS

52. Nonneoplastic Histiocytic Proliferations of Lymph Nodes and Bone Marrow 53. Histiocytic and Dendritic Cell Neoplasms Including Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma

Part VI: IMMUNODEFICIENCY DISORDERS

54. The Pathology of Primary Immunodeficiencies 55. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorder

Part VII: SITE-SPECIFIC ISSUES in the DIAGNOSIS of LYMPHOMA and LEUKEMIA

56. Bone Marrow Evaluation for Lymphoma 57. Evaluation of the Bone Marrow After Therapy 58. Non-Hematopoietic Neoplasms of the Bone Marrow 59. Nonlymphoid Lesions of the Lymph Nodes 60. Spleen: Normal Architecture and Neoplastic and Nonneoplastic Lesions 61. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin

Authors

Elaine Sarkin Jaffe Chief, Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Clinical Professor of Pathology, George Washington University School of Medicine; Series Editor, World Health Organization Classification of Tumours 4th Edition, International Agency for Research on Cancer, Bethesda, Maryland. Dr. Elaine Jaffe is regarded by her peers as one of the most pre-eminent hematopathologists of her generation. She is most widely known for her work regarding the pathophysiology and prognosis of malignant lymphomas, as well as her unparalleled work to understand how they respond to treatment. Dr. Jaffe led the effort to develop the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues published in 2001, a classification that rapidly became the international standard. Daniel A. Arber Professor and Chair of Pathology, University of Chicago School of Medicine, USA. Dr. Daniel Arber is an internationally recognized expert in the diagnosis and classification of hematopoietic tumors, including malignant lymphoma, acute and chronic leukemia, myeloproliferative disorders, myelodysplastic syndrome and tumors of the spleen. Elias Campo Chief, Hematopathology Unit, Professor of Anatomic Pathology, Clinical Director, Center for Biomedical Diagnosis, Hospital Clinic, University of Barcelona, Barcelona, Spain. the clinical director of the Biomedical Diagnostic Centre of Hospital Clinic and a full Professor of Anatomical Pathology at the University of Barcelona, where he also teaches in the Department of Anatomical Pathology, Pharmacy and Microbiology. He is the Spanish coordinator of the International Cancer Genome Consortium. Leticia Quintanilla-Fend Associate Professor, Institute of Pathology, Eberhard-Karls-University; Senior Staff, Institute of Pathology, University Hospital and Comprehensive Cancer Center, T�bingen, Germany. Professor Dr. Leticia Quintanilla de Fend, head of the Core Facility and Senior Physician at the Institute of Pathology has extensive experience in the interpretation of mouse models. From 2000 until 2008 she was a director of the mouse pathology at the Institute of Pathology of the Helmholtz Center Munich and the Pathology Screen of the German Mouse Clinic (GMC) and established various special procedures for the analysis of mouse models. Professor Quintanilla de Fend is involved in the establishment of standards in the pathology of mouse models within EU networks. Attilio Orazi Chair, Department of Pathology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas. Dr. Attilio Orazi is an internationally renowned academic hematopathologist whose diagnostic expertise spans all areas of hematopathology. However, he is best known for his expertise and scholarly accomplishments as a bone marrow pathologist. He is a member of the Scientific Committee of the European Bone Marrow Working Group, has directed courses concerning the assessment of bone marrow disorders and splenic pathology at the United States and Canadian Academy of Pathology and was the co-organizer of the 2007 Workshop of the Society of Hematopathology. Lisa M. Rimsza Department of Pathology
Mayo Clinic. Steven H. Swerdlow Professor of Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.