Phytochemicals in Cancer Therapy and Beyond explores the significant role of natural products in combating diseases, particularly cancer. The book emphasizes the mechanisms through which natural products operate in treatments, making it a comprehensive guide for understanding their therapeutic potential. Spanning 24 chapters, it delves into regular cancer treatments, challenges faced, and advancements in the field. Special focus is given to phytochemicals and their cellular mechanisms, molecular pathways in therapy, and innovative nano-scale delivery systems that enhance treatment efficacy.
This book is an essential resource for oncology researchers, disease therapy experts, diabetes mellitus treatment professionals, cellular signaling scientists, and nanomaterial engineers, offering valuable insights into the clinical applications of phytochemical therapies.
Table of Contents
Section I: Cancer treatment and challenges
1: New developments in treatment of cancer
2: A summary of molecular pathways responsible for cancer progression
3: Challenges in treatment of cancer with conventional strategies
Section II: Phytochemicals and cancer therapy
4: Phytochemicals in suppressing cancer proliferation
5: Phytochemicals in suppressing cancer metastasis
6: Phytochemicals in providing cancer therapy sensitivity
Section III: Phytochemicals in the treatment of other diseases
7: Phytochemicals in treatment of Diabetes mellitus
8: Phytochemicals in treatment of neurological diseases
9: Phytochemicals in treatment of ischemic/reperfusion injury
10: Phytochemicals in treatment of infectious diseases
Section IV: Phytochemicals and cellular mechanisms in cancer therapy
11: Phytochemicals in regulating glycolysis in cancer
12: Phytochemicals in regulating apoptosis in cancer
13: Phytochemicals in regulating autophagy in cancer
14: Phytochemicals in regulating EMT and MMPs in cancer
Section V: Phytochemicals and molecular pathways in cancer
15: Phytochemicals in regulating STAT3 signaling in cancer
16: Phytochemicals in regulating Wnt signaling in cancer
17: Phytochemicals in regulating NF-kB signaling signaling in cancer
18: Phytochemicals in regulating PTEN/PI3K/Akt signaling in cancer
19: Phytochemicals in regulating non-coding RNAs in cancer
Section VI: Nano-scale delivery systems for phytochemicals in cancer therapy
20: Polymeric nanoparticles for delivery of phytochemicals in cancer therapy
21: Lipid-based nanoparticles for delivery of phytochemicals in cancer therapy
22: Carbon- and metal-based nanomaterials for delivery of phytochemicals in cancer therapy
Section VII: Clinical applications
23: Application of phytochemicals in clinical trials for treatment of diseases and malignant tumors
24: The market of natural products around the world
Authors
Gautam Sethi Associate Professor, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Dr. Gautam Sethi is a tenured Associate Professor in Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. The focus of his research over the past few years has been to elucidate the mechanism(s) of activation of oncogenic transcription factors by carcinogens and inflammatory agents and the identification of novel inhibitors of these proteins for prevention of and therapy for cancer. The findings of his research work have so far resulted several publications in high impact factor peer reviewed journals and many international awards. He also serves as an editorial board member for over more than 15 international journals Milad Ashrafizadeh Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey. Dr Milad Ashrafizadeh is a researcher in Sabanci university, Turkey and obtained his degree in field of Veterinary Medicine in 2020. He is an invited scholar in University of Electronic Science & Technology of China. Currently, Milad is an Editorial Board in journal of nanostructure in chemistry (IF= 6.39) and is a review editor in Frontiers journals. He has published review and research articles in international and famous journals in world. Milad has also 4 book chapters. He has published articles in high quality journals including Nanotoday, Coordination Chemistry Reviews, Advanced Science, Carbohydrate Polymers, Journal of Controlled Release and Advances in Colloid and Interface Science, among others. His interests include nanomedicine, application of nanoparticles for drug and gene delivery, targeted cancer therapy, non-coding RNAs in cancer and development of biosensors. Navid Rabiee Saveetha University.Dr. Navid Rabiee, Ph.D., is a leading scientist with over 42,000 citations and an H-index of 72. He integrates molecular and cellular biology with engineering to design advanced medical systems. He is a pioneer in the field of BioInorganic Chemistry with an emphasis on CRISPR delivery with the assistance of inorganic nano-vectors. Also, he is the pioneer in developing high-gravity synthesis methods for porous (in)organic nanomaterials to follow the green chemistry principles, which led to the foundations of a new field called "Green Biomaterials�. With 300+ peer-reviewed articles in top journals (including Nature, Nature Medicine, Advanced Materials, The Lancet), 9 books, and 20+ chapters, his work advances medical treatment and sustainable practices.
