Caspases as Molecular Targets for Cancer Therapy discusses recent developments on targeted therapies for cancer using caspases. It describes the selection of specific caspases for cancer therapy with the current standard-of-care and highlights numerous assay techniques for caspases activities. The book discusses topics such as mutations within apoptosis gene, inflammatory caspases, tumor suppression, and the different caspases types and their role in anticancer activity. In addition, it discusses caspases activity assay procedure and future perspectives. It is a valuable resource for researchers, students and members of the biomedical and medical fields who want to learn more about novel anticancer targeted therapies.
Table of Contents
1. Introduction to Caspases, its function, mechanism, and classification2. Mutations within apoptosis gene and caspases
3. Inflammatory caspases -1, -4, and -5 and their role in anticancer activity
4. Caspase-2 and tumor suppression
5. Caspase-3: A promising target for anticancer agents
6. Caspase-7 mutations and its activators
7. Re-instating the expression and activation of caspase-8 and caspase-10 in cancer therapy
8. Caspase-9 gene mutation and its activators
9. Caspases activity assay procedure
10. Current and future prospective of caspases targeting in cancer therapy
