Pediatric Brain Tumors - Pipeline Insight, 2024

This “Pediatric Brain Tumors - Pipeline Insight, 2024,” report provides comprehensive insights about 7+ companies and 7+ pipeline drugs in Pediatric Brain Tumors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Pediatric Brain Tumors Understanding

Pediatric Brain Tumors: Overview

Pediatric brain tumors consist of a diverse group of neoplasms of the spinal cord and the brain. They are usually primary but can progress to metastatic stage as well. Primary brain tumors are pretty common in children only after leukemia. Primitive neuroectodermal tumors (PNETs), benign gliomas, and craniopharyngiomas are the major tumors affecting children. Astrocytoma is the commonest tumor of the central nervous system in children.

Symptoms
Signs and symptoms of pediatric brain tumors may depend upon the location, size, and rate of growth of the tumor. Some common symptoms associated with brain tumor in children are abrupt onset of vision-related problems, headaches which may progress to become more severe and frequent, unexplained vomiting or nausea, and feeling of increased pressure in the head. A few other symptoms may include slurred speech, fuller soft spot on the skull of babies, personality or behavioral changes, trouble walking and maintaining body balance, and trouble swallowing among others.

Diagnosis
The diagnosis of brain tumor in children is done by various techniques after a thorough physical examination is done. Imaging tests such as MRI, CT, and positron emission tomography may be done to identify the location and size of the tumor. Biopsy, precision medicine diagnosis, and tests to determine the spread of tumor may also be done.

Treatment
Treatment of pediatric brain tumors may depend upon on the size, type, location, and the age and overall health of the child. Surgery, traditional radiation therapy, radiosurgery, proton beam therapy, targeted drug therapy, chemotherapy, and further rehabilitation are treatments that may be carried out.

Pediatric Brain Tumors Emerging Drugs Chapters

This segment of the Pediatric Brain Tumors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Pediatric Brain Tumors Emerging Drugs

INXN 2001: ZIOPHARM Oncology INXN 2001, also known as Ad-RTS-h IL-12 plus veledimex is being developed by ZIOPHARM ONCOLOGY for pediatric brain tumor/ diffuse intrinsic pontine glioma (DIPG). It is in the phase I/II of drug development where dose-escalation study for pediatric cases of glioma including DIPG. It is a controlledIL-12monotherapy.

MTX110: Midatech Pharma Midatech pharma’s product MTX110 is being tested for the treatment of childhood brain cancers such as DIPG as well as Medulloblastoma. The drug has received the orphan drug designation by the U.S. Food and Drug Administration for Malignant Glioma, including DIPG. It is a novel formulation of the HDAC-inhibitor panobinostat in solubilized form which is being studied in an ongoing combine Phase I and Phase II in DIPGpatients.

Pediatric Brain Tumors: Therapeutic Assessment

This segment of the report provides insights about the different Pediatric Brain Tumors drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Pediatric Brain Tumors

There are approx. 7+ key companies which are developing the therapies for Pediatric Brain Tumors. The companies which have their Pediatric Brain Tumors drug candidates in the mid to advanced stage, i.e. phase III and Phase II include, Midatech Pharma and others.

Phases

This report covers around 7+ products under different phases of clinical development like

• Mid-stage products (Phase II)
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Pediatric Brain Tumors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Subcutaneous
• Intravenous
• Oral
• Intramuscular

Molecule Type

Products have been categorized under various Molecule types such as

• Small molecules
• Natural metabolites
• Monoclonal antibodies

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Pediatric Brain Tumors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Pediatric Brain Tumors therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Pediatric Brain Tumors drugs.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Pediatric Brain Tumors R&D. The therapies under development are focused on novel approaches to treat/improve Pediatric Brain Tumors.

Pediatric Brain Tumors Report Insights

• Pediatric Brain Tumors Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Pediatric Brain Tumors Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Pediatric Brain Tumors drugs?
• How many Pediatric Brain Tumors drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Pediatric Brain Tumors?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Pediatric Brain Tumors therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Pediatric Brain Tumors and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Midatech Pharma
• Y-mAbs Therapeutics
• ZIOPHARM Oncology

Key Products

• MTX110
• INXN 2001
• 177Lu-omburtamab-DTPA

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