Fundamentals and Biomedical Applications of Chitosan Nanoparticles holistically covers the development and application of chitosan nanoparticles, providing an accessible and interdisciplinary resource for both those new to the field and those who wish to deepen their knowledge. The book begins with an introduction to synthesis methods, fundamental chemistry, characterization, and surface functionalization of chitosan nanoparticles, guiding the reader through each stage of development. A wide range of biomedical applications are explored, from vaccine delivery, tumor targeting, tissue engineering, and wound healing and antimicrobial therapy. This will be a helpful guide for postgraduate students and researchers who are starting out in this field, as well as established researchers in the fields of materials science, nanotechnology, materials chemistry, and bioscience.
Table of Contents
1. Chitosan Nanoparticles: Fundamental Chemistry, Unique Physical and Chemical Properties and Current Research Trends in Biomedical Field 2. Synthesis Methods of Chitosan Nanoparticles: An Overview 3. Spectroscopic and Microscopic Characterizations of Chitosan Nanoparticles 4. Biocompatibility, Biodegradability and Toxicity Evaluations of Chitosan Nanoparticles 5. Surface Functionalization, Crosslinking and Grafting of Chitosan Nanoparticles 6. Chitosan Nanoparticles: A Promising Tool in Nanomedicine 7. Chitosan Nanoparticles as Drug Carriers and Gene Delivery Systems: Advances and Challenges 8. Chitosan Nanoparticles in Vaccine Delivery Systems 9. Chitosan Nanoparticles for Antimicrobial Applications 10. Chitosan Nanoparticles in Tumor Imaging and Therapy 11. Hybrid Chitosan Nanoparticles for Sequential Targeting of Breast, Liver and Brain Cancers 12. Chitosan Nanoparticles for Cancer Diagnosis and Therapy 13. Chitosan Nanoparticles in Tissue Engineering and Regenerative Medicine 14. Chitosan Nanoparticles in Wound Healing and Dressing Applications 15. Application of Chitosan Nanoparticles in Veterinary Medicine and Diagnostics 16. Chitosan Nanoparticles-Hydrogel Composites for Biomedical Applications 17. Regulatory Status, Toxicological, Environmental and Health Impact of Chitosan Nanoparticles 18. Challenges and Future Perspectives of Chitosan Nanoparticles in Biomedical Applications
Authors
Kalim Deshmukh Senior Researcher, New Technologies - Research Centre, University of West Bohemia, Czech Republic. Kalim Deshmukh is a senior researcher at the New Technologies Research Centre, University of West Bohemia, Pilsen, Czech Republic. His research interest is mainly focused on the synthesis, characterization, and property investigations of polymer nanocomposites reinforced with different nanofillers (including various nanoparticles and carbon allotropes such as carbon black, carbon nanotubes, and graphene and its derivatives) for energy storage, energy harvesting, gas sensing, EMI shielding, and high-k dielectric applications. Jagan Mohan Dodda Department of Chemical Processes and Biomaterials, New Technologies - Research Centre, University of West Bohemia, Univerzitn�, Pilsen, Czech Republic. Dr. Jagan Mohan Dodda is a Senior Researcher at the New Technology Research Institute, University of West Bohemia, Czech Republic. He obtained his Ph.D. in Chemistry from Central Salt & Marine Chemicals Research Institute (Bhavnagar University), Gujarat, India. Later, he worked as a postdoctoral researcher at Akita University (Japan), Korea Forest Research Institute (South Korea) and University Sains Malaysia (Malaysia). He has 14 years of teaching and research experience in the field of Polymer Science and Technology. He specializes in the synthesis and characterization of biocompatible materials for biomedical applications, high-performance polymers, membranes, hydrogels and polymeric nanomaterials etc. He is the author of 30 research articles (>1000 citations) in reputed scientific journals, e.g., Journal of Membrane Science, European Polymer Journal, Polymer International, Desalination, Macromolecular Bioscience, Polymer Degradation and Stability, Carbon, etc. Ibrahim M. El-Sherbiny Professor of Smart Nanomaterials and Nanomedicine, Founding Chairman of Nanoscience Program, Founding Director of the Center of Materials Science, Zewail City of Science and Technology, Giza, Egypt. Dr. Ibrahim M. El-Sherbiny is a Tenured Professor of smart nanomaterials and nanomedicine, and he is the Founding Chairman of Nano and Materials Sciences Programs, and the Director of the Center of Materials Science (CMS) at Zewail City of Science and Technology. El-Sherbiny earned his PhD from Massey University, New Zealand, then joined various research groups as a post-doctoral fellow at College of Pharmacy, University of New Mexico and Texas University-Austin in the United States. Then, appointed as Research Assistant Professor at College of Pharmacy, University of Texas-Austin, USA. Dr. El-Sherbiny received several honouring and local, regional and international scientific awards, including, for example, the Order of the Egyptian Republic in Science and Arts of the first class and an honor, the State Award for Excellence in Advanced Technological Sciences, and the Egyptian State Encouragement Award in Science in 2011. He also received two gold medals in addition to two honorary diplomas from the 46th International Exhibition of Innovation in Geneva, Switzerland, as well as a number of medals and diplomas from France, Malaysia, Romania, and the Gulf Cooperation Council, in recognition of his innovations in the use of nanotechnology in biomedical applications. El-Sherbiny's research focuses on the design and development of new classes of smart nano- and nano-in-micro matrices using advanced nanotechnology techniques and evaluating these new structures as potential candidates in various biotechnological and biomedical applications including targeted and controlled drug delivery, tissue engineering, regenerative medicine, and biosensing. Dr. El-Sherbiny is the author/editor of two books plus contribution to more than other 30 books, and more than fifteen review articles. He is also a named inventor on more than 25 patents in U.S., U.K., Europe and Egypt. He is a member of different societies and associations including the American Association of Pharmaceutical Scientists, the Biomedical Engineering Society (U.S.), the American Chemical Society (U.S.), the Egyptian Chemical Society, the Egyptian Society for Polymer Science & Technology, and the Materials Research Society (U.S.). Besides, he is the A. Editor of the long-lasting Drug Development and Industrial Pharmacy journal plus being an editorial board member of many other well-respected nano- and pharmaceutical journals. Emmanuel Rotimi Sadiku Professor, Tshwane University of Technology, South Africa.Prof. Rotimi Sadiku, currently a Professor at the Department of Chemical, Metallurgical, and Materials Engineering at Tshwane University of Technology, South Africa, earned his BSc. [Hons] and a PhD from the University of Strathclyde, Glasgow, UK, specializing in Polymer Physics with a focus on Polymer Processing, X-ray Diffraction, Thermal Characteristics, Rheology, and Microscopy of Polymers techniques.
His academic journey includes a role as a Lecturer II at the Federal University of Technology in Nigeria, followed by a Postdoctoral Research Fellowship at the University of Genova/CNR, Italy. Upon returning to Nigeria, he continued his career by joining the Federal University of Technology, where he served as a Senior Lecturer. He also spent a year as a Research Fellow at the KTH Institute of Technology in Stockholm, Sweden. In January 2004, he assumed his current position as a Research Professor at Tshwane University of Technology (TUT), South Africa.
