Stem cells with self-renewal and multi-lineage differentiation potential have potential for developing medicines for a range of refractory and recurrent disease. This book mainly focuses on the landscape of the biological properties and translational research of stem cells types, including hematopoietic stem cells (HSCs), neural stem cells (NSCs) and mesenchymal stem/stromal cells (MSCs).
The book also introduces readers to the current updates and development prospects of stem cells in singular or combination therapies with advanced biomaterials and technological innovations towards large-scale standardization and productization.
Key Features:
- Introduces readers to stem cell biology and tissue engineering
- Covers innovations in stem cell therapy and biomaterials
- Includes a brief guide to commercialization of stem cell technology
- Includes references for advanced readers
The contents will strengthen the reader’s understanding of stem cell-based therapies. This book is a primer on stem cell and regenerative medicine for a wide readership including, students, healthcare professionals, researchers and general readers.
Readership
Students, healthcare professionals, researchers and general readers.
Table of Contents
CHAPTER 1 THE HISTORICAL OVERVIEW OF STEM CELLS
- INTRODUCTION
- THE DEFINITION AND HISTORY OF STEM CELLS
- THE CHARACTERISTICS AND BIOLOGY OF STEM CELLS
- THE CLASSIFICATION OF STEM CELLS
- THE SAFETY AND EFFICACY OF STEM CELLS
- CONCLUSION
- ABBREVIATIONS
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 2 BIOMATERIALS AND STEM CELLS
- INTRODUCTION
- HYDROGEL/STEM CELL COMPOSITE
- COLLAGEN SCAFFOLD/STEM CELL COMPOSITE
- NANOMATERIALS/STEM CELL COMPOSITE
- BIOMATERIALS AND DERIVATIVES OF STEM CELLS
- CONCLUSION
- LIST OF ABBREVIATIONS
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 3 HEMATOPOIETIC STEM CELLS IN REGENERATIVE MEDICINE
- INTRODUCTION
- THE OVERVIEW OF HEMATOPOIETIC STEM CELLS (HSCS)
- THE ORIGINS AND DEVELOPMENT OF HSCS
- THE PRECLINICAL AND CLINICAL APPLICATIONS OF HSCS
- CONCLUSION
- LIST OF ABBREVIATIONS
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 4 NEURAL STEM CELLS IN TISSUE ENGINEERING
- INTRODUCTION
- THE OVERVIEW OF NEURAL STEM CELLS (NSCS)
- THE ORIGINS AND DEVELOPMENT OF NSCS
- THE APPLICATION OF NSCS AND THE UNDERLYING MOLECULAR MECHANISM 61
- CONCLUSION
- LIST OF ABBREVIATIONS
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 5 BIOMATERIALS AND MESENCHYMAL STEM CELLS
- INTRODUCTION
- THE BIOLOGICAL PROPERTIES OF MSCS
- THE ORIGINS AND DEVELOPMENT OF MSCS
- THE APPLICATION AND MOLECULAR MECHANISM OF MSCS
- THE STANDARDIZATION AND INDUSTRIALIZATION OF MSCS
- CONCLUSION
- LIST OF ABBREVIATIONS
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 6 STEM CELLS-BASED TECHNOLOGICAL INNOVATION IN TISSUE
- ENGINEERING
- INTRODUCTION
- THREE-DIMENSIONAL (3D) PRINTING
- ORGANOID
- GENE EDITING AND STEM CELL-BASED GENE THERAPY
- IN VIVO FLUORESCENT TRACER
- SINGLE-CELL RNA SEQUENCING (SCRNA-SEQ)
- CONCLUSION
- LIST OF ABBREVIATIONS
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 7 MSCS AS BIOLOGICAL DRUGS: FROM MANUFACTURING TO COMMERCIALIZATION
- INTRODUCTION
- PROCESS DEVELOPMENT OF MESENCHYMAL STEM CELLS PRODUCTS
- CHEMISTRY, MANUFACTURING, AND CONTROLS (GMP)
- Raw Materials and Excipients
- Raw Materials
- Excipients
- Process
- Quality Research and Quality Control
- Stability Studies of MSC Products
- Packaging and Closed Container Systems
- PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES (GLP)
- MESENCHYMAL STEM CELLS: CLINICAL TRIALS (GCP)
- MSC-BASED PRODUCTS IN THE MARKET
- REGULATIONS AND GUIDANCE OF MSC PRODUCTS
- CONCLUSION
- ACKNOWLEDGEMENTS
- REFERENCES
- SUBJECT INDEX
Author
- Leisheng Zhang
