The global liquid chromatography-mass spectrometry (LS-MS) market accounted for USD 6.38 billion in 2023 and is expected to reach USD 26.41 billion by 2034 with a CAGR of 13.78% during the forecast period 2024-2034. The market will grow as a result of rising R&D spending in the healthcare industry, rising demand for sophisticated analytical techniques, growing emphasis on environmental monitoring, advancements in LC-MS technology, growing use of personalized medicine, and strategic alliances and collaborations.
The capabilities and performance of LC-MS systems are continuously improved by LC and MS technology developments, such as increased resolution, sensitivity, and speed. Market expansion is fueled by the release of high-resolution and hybrid mass spectrometers with improved analytical capabilities. The workflow efficiency and analytical throughput are increased when LC-MS systems are integrated with automation and data processing software, increasing market demand. For instance, Agilent Technologies announced the release of its Ultivo Triple Quadrupole LC/MS system in January 2022. This system is intended to provide outstanding sensitivity and resilience for a variety of applications.
By product type, the reversed-phase liquid chromatography (RPLC) segment accounted for the highest revenue-grossing segment in the global liquid chromatography-mass spectrometry (LS-MS) market in 2023 owing to the widespread use in pharmaceutical, biotechnology, and clinical research applications, driven by its ability to separate complex mixtures efficiently and its compatibility with mass spectrometry detection. For instance, Shimadzu Corporation released the Nexera Prep liquid chromatograph system in February 2022 to streamline purification procedures in biotech and pharmaceutical labs. Additionally, the ultra-high pressure liquid chromatography (UHPLC) segment is predicted to grow at the fastest CAGR during the forecast period owing to its superior speed, resolution, and sensitivity, enabling quicker analyses, higher throughput, and improved detection limits compared to traditional HPLC systems.
By platform, the single mass spectrometry segment accounted for the highest revenue-grossing segment in the global liquid chromatography-mass spectrometry (LS-MS) market in 2023 owing to its cost-effectiveness, versatility, and widespread adoption across various industries such as pharmaceuticals, biotechnology, environmental testing, and food safety. For instance, PerkinElmer, Inc. strengthened its portfolio in the life sciences and diagnostics in January 2022 when it announced the acquisition of Horizon Discovery Group plc, a leader in cell engineering and gene editing technology. Additionally, the hybrid mass spectrometry segment is predicted to grow at the fastest CAGR during the forecast period owing to its superior analytical capabilities, offering enhanced sensitivity, resolution, and flexibility for complex sample analyses across multiple applications in pharmaceuticals, proteomics, metabolomics, and environmental testing.
By application, the pharmaceutical and biotech segment accounted for the highest revenue-grossing segment in the global liquid chromatography-mass spectrometry (LS-MS) market in 2023 owing to the increasing demand for drug development, quality control, and regulatory compliance, driving the adoption of LC-MS technology for precise and sensitive analysis in pharmaceutical and biotech research and manufacturing processes. For instance, Agilent Technologies announced the release of its Ultivo Triple Quadrupole LC/MS system in January 2022. This system is intended to provide outstanding sensitivity and resilience for a variety of applications. Additionally, the clinical diagnostics segment is predicted to grow at the fastest CAGR during the forecast period owing to the rising demand for accurate and sensitive analytical techniques for disease diagnosis, biomarker discovery, and therapeutic monitoring, driving the adoption of liquid chromatography-mass spectrometry (LC-MS) technology in clinical laboratories and healthcare settings.
By end-user, the biotechnological and pharmaceutical industries segment accounted for the highest revenue-grossing segment in the global liquid chromatography-mass spectrometry (LS-MS) market in 2023 owing to the critical need for precise analysis in drug discovery, development, and quality control processes, driving widespread adoption of LC-MS technology within these sectors. For instance, Shimadzu Corporation introduced the Nexera Lite LC-MS system in January 2024. It is a cost-effective and small-sized solution for routine LC-MS analysis. Additionally, the research laboratories segment is predicted to grow at the fastest CAGR during the forecast period owing to the increasing investments in scientific research, rising demand for advanced analytical techniques, and expanding applications of liquid chromatography-mass spectrometry (LC-MS) across various fields such as life sciences, environmental science, and material science.
North American region is anticipated to have the highest revenue share during the forecast period owing to the presence of key market players, robust healthcare infrastructure, significant R&D investments, and stringent regulatory standards. Additionally, the Asia Pacific region is predicted to grow at the fastest CAGR during the forecast period owing to the increasing industrialization, rising investments in healthcare infrastructure, expanding pharmaceutical and biotechnology sectors, and growing adoption of advanced analytical technologies like liquid chromatography-mass spectrometry (LC-MS) across various applications in research, clinical diagnostics, and environmental testing. For instance, Thermo Fisher Scientific introduced the new Thermo Scientific Vanquish UHPLC system in February 2024, which boasts enhanced sensitivity, speed, and resolution for sophisticated analytical applications.
This extensive research report concentrates on the size and projections of the global and regional markets from 2023 to 2034.
The capabilities and performance of LC-MS systems are continuously improved by LC and MS technology developments, such as increased resolution, sensitivity, and speed. Market expansion is fueled by the release of high-resolution and hybrid mass spectrometers with improved analytical capabilities. The workflow efficiency and analytical throughput are increased when LC-MS systems are integrated with automation and data processing software, increasing market demand. For instance, Agilent Technologies announced the release of its Ultivo Triple Quadrupole LC/MS system in January 2022. This system is intended to provide outstanding sensitivity and resilience for a variety of applications.
By product type, the reversed-phase liquid chromatography (RPLC) segment accounted for the highest revenue-grossing segment in the global liquid chromatography-mass spectrometry (LS-MS) market in 2023 owing to the widespread use in pharmaceutical, biotechnology, and clinical research applications, driven by its ability to separate complex mixtures efficiently and its compatibility with mass spectrometry detection. For instance, Shimadzu Corporation released the Nexera Prep liquid chromatograph system in February 2022 to streamline purification procedures in biotech and pharmaceutical labs. Additionally, the ultra-high pressure liquid chromatography (UHPLC) segment is predicted to grow at the fastest CAGR during the forecast period owing to its superior speed, resolution, and sensitivity, enabling quicker analyses, higher throughput, and improved detection limits compared to traditional HPLC systems.
By platform, the single mass spectrometry segment accounted for the highest revenue-grossing segment in the global liquid chromatography-mass spectrometry (LS-MS) market in 2023 owing to its cost-effectiveness, versatility, and widespread adoption across various industries such as pharmaceuticals, biotechnology, environmental testing, and food safety. For instance, PerkinElmer, Inc. strengthened its portfolio in the life sciences and diagnostics in January 2022 when it announced the acquisition of Horizon Discovery Group plc, a leader in cell engineering and gene editing technology. Additionally, the hybrid mass spectrometry segment is predicted to grow at the fastest CAGR during the forecast period owing to its superior analytical capabilities, offering enhanced sensitivity, resolution, and flexibility for complex sample analyses across multiple applications in pharmaceuticals, proteomics, metabolomics, and environmental testing.
By application, the pharmaceutical and biotech segment accounted for the highest revenue-grossing segment in the global liquid chromatography-mass spectrometry (LS-MS) market in 2023 owing to the increasing demand for drug development, quality control, and regulatory compliance, driving the adoption of LC-MS technology for precise and sensitive analysis in pharmaceutical and biotech research and manufacturing processes. For instance, Agilent Technologies announced the release of its Ultivo Triple Quadrupole LC/MS system in January 2022. This system is intended to provide outstanding sensitivity and resilience for a variety of applications. Additionally, the clinical diagnostics segment is predicted to grow at the fastest CAGR during the forecast period owing to the rising demand for accurate and sensitive analytical techniques for disease diagnosis, biomarker discovery, and therapeutic monitoring, driving the adoption of liquid chromatography-mass spectrometry (LC-MS) technology in clinical laboratories and healthcare settings.
By end-user, the biotechnological and pharmaceutical industries segment accounted for the highest revenue-grossing segment in the global liquid chromatography-mass spectrometry (LS-MS) market in 2023 owing to the critical need for precise analysis in drug discovery, development, and quality control processes, driving widespread adoption of LC-MS technology within these sectors. For instance, Shimadzu Corporation introduced the Nexera Lite LC-MS system in January 2024. It is a cost-effective and small-sized solution for routine LC-MS analysis. Additionally, the research laboratories segment is predicted to grow at the fastest CAGR during the forecast period owing to the increasing investments in scientific research, rising demand for advanced analytical techniques, and expanding applications of liquid chromatography-mass spectrometry (LC-MS) across various fields such as life sciences, environmental science, and material science.
North American region is anticipated to have the highest revenue share during the forecast period owing to the presence of key market players, robust healthcare infrastructure, significant R&D investments, and stringent regulatory standards. Additionally, the Asia Pacific region is predicted to grow at the fastest CAGR during the forecast period owing to the increasing industrialization, rising investments in healthcare infrastructure, expanding pharmaceutical and biotechnology sectors, and growing adoption of advanced analytical technologies like liquid chromatography-mass spectrometry (LC-MS) across various applications in research, clinical diagnostics, and environmental testing. For instance, Thermo Fisher Scientific introduced the new Thermo Scientific Vanquish UHPLC system in February 2024, which boasts enhanced sensitivity, speed, and resolution for sophisticated analytical applications.
This extensive research report concentrates on the size and projections of the global and regional markets from 2023 to 2034.
Report Scope:
- Base Year: 2023
- Forecast Period: 2024-2034
- Study Coverage
- Market Forecast by Product Type, Platform, Application, and End-User
- Market Forecast for 5 Regions and 17+ Countries
- North America (U.S. and Canada)
- Europe (Germany, France, UK, Spain, Italy, Russia, Rest of Europe)
- Asia Pacific (China, Japan, India, Australia, South Korea, Rest of APAC)
- Latin America (Brazil, Mexico, Argentina, Rest of LATAM)
- MEA (South Africa, GCC, Rest of MEA)
- Exhaustive Company Profiles of the Top 10+ Major Market Players
Segmentation: Liquid Chromatography-Mass Spectrometry (LS-MS) Market Report 2023 - 2034
Liquid Chromatography-Mass Spectrometry (LS-MS) Market Analysis & Forecast by Product Type 2023 - 2034 (Revenue USD Bn)
- Normal-Phase Liquid Chromatography (NPLC)
- Reversed-Phase Liquid Chromatography (RPLC)
- Ion Exchange Liquid Chromatography (IELC)
- Size Exclusion Liquid Chromatography (SELC)
- High-Performance Liquid Chromatography (HPLC)
- Ultra-High Pressure Liquid Chromatography (UHPLC)
- Low-Pressure Liquid Chromatography (LPLC)
- Others
Liquid Chromatography-Mass Spectrometry (LS-MS) Market Analysis & Forecast by Platform 2023 - 2034 (Revenue USD Bn)
- Single Mass Spectrometry
- Hybrid Mass Spectrometry
- Others
Liquid Chromatography-Mass Spectrometry (LS-MS) Market Analysis & Forecast by Application 2023 - 2034 (Revenue USD Bn)
- Pharmaceutical
- Biotech
- Petrochemical
- Environmental Testing
- Food and Beverage Testing
- Others
Liquid Chromatography-Mass Spectrometry (LS-MS) Market Analysis & Forecast by End-User 2023 - 2034 (Revenue USD Bn)
- Biotechnological and Pharmaceutical Industries
- Research Laboratories
- Diagnostic Laboratories
- Industrial
- Government and Public
Liquid Chromatography-Mass Spectrometry (LS-MS) Market Analysis & Forecast by Region 2023 - 2034 (Revenue USD Bn)
- North America
- U.S.
- Canada
- Europe
- Germany
- France
- UK
- Spain
- Italy
- Rest of Europe
- Asia Pacific
- China
- Japan
- India
- Australia
- South Korea
- Rest of APAC
- Latin America
- Brazil
- Mexico
- Argentina
- Rest of LATAM
- Middle East & Africa
- South Africa
- GCC
- Rest of MEA
Table of Contents
1. Research Methodology
2. Introduction
4. Market Environment Analysis
5. Market Dynamics
7. Liquid Chromatography-Mass Spectrometry (LS-MS) Market: Product Type Estimates & Trend Analysis
8. Liquid Chromatography-Mass Spectrometry (LS-MS) Market: Platform Estimates & Trend Analysis
9. Liquid Chromatography-Mass Spectrometry (LS-MS) Market: Application Estimates & Trend Analysis
10. Liquid Chromatography-Mass Spectrometry (LS-MS) Market: End-user Estimates & Trend Analysis
11. Regional Market Analysis
12. North America Liquid Chromatography-Mass Spectrometry (LS-MS) Market
13. Europe Global Liquid Chromatography-Mass Spectrometry (LS-MS) Market
14. Asia Pacific Global Liquid Chromatography-Mass Spectrometry (LS-MS) Market
15. Latin America Global Liquid Chromatography-Mass Spectrometry (LS-MS) Market
16. MEA Global Liquid Chromatography-Mass Spectrometry (LS-MS) Market
17. Competitor Analysis
18. Company Profiles
Companies Mentioned
- Agilent Technologies
- Thermo Fisher Scientific
- Waters Corporation
- Shimadzu Corporation
- Bruker Corporation
- PerkinElmer Inc.
- SCIEX (a division of Danaher Corporation)
- JEOL Ltd.
- AB Sciex Pte. Ltd.
- Hitachi High-Tech Corporation
- Agilent Technologies
- Restek Corporation
- Analytik Jena AG
- LECO Corporation
- Rigaku Corporation.
