Over the past 50 years, more than 20,000 natural compounds have been identified in the marine environment, with an increasing focus on marine metabolites as potential sources for developing effective therapeutic agents. The field of marine drug discovery has seen remarkable growth in recent years, with numerous marine-derived therapeutic candidates in various stages of clinical trials or awaiting approval. The ocean is a potential source of natural products with diverse pharmacological properties, including antimicrobial, anticancer, antiviral, antioxidative, and anti-inflammatory activities. However, commercializing marine natural products has been challenging due to low yields and specificity of specialized (secondary) metabolites. Marine Specialized (Secondary) Metabolites and their Diverse Applications provides a broad overview of marine specialized metabolites and their potential in various industries. With comprehensive coverage, relevance to current trends, interdisciplinary approach, and practical applications, this book includes specific compounds or organisms, with a particular focus on addressing the challenges and limitations associated with them.
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Table of Contents
Part I Chemistry and biochemistry of marine specialized metabolites1. Phenolic compounds and their halogenated derivatives
2. Terpenoids
3. Alkaloids
4. Sterols
5. Saccharide derivatives
6. Peptides
Part II Application of marine specialized metabolites
7. Marine secondary metabolites; in the long haul fight against cancer
8. Marine secondary metabolites in oxidative stress are promising
9. Promoting marine specialized metabolites against inflammation
10. Marine neutraceuticals; a solution for digestive tract health
11. Future prospects of marine resources in fighting diabetics
12. Advances and prospects in the field of cosmeceuticals with marine resources
13. Marine environment as a wonderful source over viral infections
14. Reverse aging is possible with marine resources
15. How to implement marine secondary metabolites in obesity struggle
16. Antimicrobial properties of marine specialized metabolites
Part III Marine organisms as a natural product resource and beyond
17. Marine secondary metabolites as a natural product resource
18. Contributions of marine secondary metabolites to medicinal chemistry
19. Blue-bioeconomy; marine specialized metabolites at the forefront
20. Marine secondary metabolites; an underexplored subject in metabolomics
21. Advances in marine secondary metabolite based metabolmics
Authors
Thilina Uduwaka Jayawardena Department of Medicine, University of Alberta. Dr. Thilina U. Jayawardena is a research scientist with an interdisciplinary background in natural products chemistry, chemical biology, and cardiovascular molecular biology. He is currently a postdoctoral fellow in the Department of Medicine at the University of Alberta, where his research focuses on cardiomyopathy, ER stress, and gene-therapy-based approaches targeting the renin-angiotensin system. He previously held postdoctoral positions at the University of Calgary and the Universit� du Qu�bec � Trois-Rivi�res. Dr. Jayawardena's work integrates wet-lab and multi-omics approaches to study disease mechanisms and therapeutic targets. He has authored numerous peer-reviewed publications. Asanka Sanjeewa Senior Lecturer, University of Sri Jayewardenepura, Sri Lanka.Dr. Asanka Sanjeewa is Senior Lecturer at the University of Sri Jayewardenepura. He obtained his MSc and PhD in Marine Bioresource Technology at Jeju National University in South Korea, and he conducted his post-doctoral research in the Marine Bioresource Technology Laboratory of the Department of Marine Life Sciences at the School of Marine Biomedical Science at Jeju National University in South Korea. Dr. Sanjeewa's primary research interests focus on utilizing marine bioresources to develop functional products, such as nutraceuticals, cosmeceuticals, and functional foods. He co-led several book publications, including Elsevier's forthcoming Marine Specialized (secondary) Metabolites and Their Diverse Applications.
