In-Vitro Transcription Templates Market Report 2025

The in-vitro transcription templates market size has grown exponentially in recent years. It will grow from $1.01 billion in 2024 to $1.24 billion in 2025 at a compound annual growth rate (CAGR) of 22.7%. The growth in the historic period can be attributed to rise in cases of chronic diseases, increase in investments in R&D in healthcare and pharmaceutical sectors, improvements in gene therapy technology, collaborations and partnerships and developments in gene therapy.

The in-vitro transcription templates market size is expected to see exponential growth in the next few years. It will grow to $2.73 billion in 2029 at a compound annual growth rate (CAGR) of 21.8%. The growth in the forecast period can be attributed to Increase in advancement in biotechnology, rise in focus in R&D activities, rise in usage of in-vitro transcription templates, demand for early diagnosis of diseases and increasing need for mRNA-based vaccines. Major trends in the forecast period include developments in RNA synthesis technologies, technological advancements, advancement in biotechnology, advancements in enzymatic synthesis techniques, and integration of automation and digitalization.

The forecast of 21.8% growth over the next five years reflects a modest reduction of 1.6% from the previous estimate for this market. This reduction is primarily due to the impact of tariffs between the US and other countries. Trade tensions could hinder U.S. biotech firms by inflating prices of synthetic mRNA templates developed in Germany and Singapore, resulting in delayed vaccine research and higher gene therapy development costs. The effect will also be felt more widely due to reciprocal tariffs and the negative effect on the global economy and trade due to increased trade tensions and restrictions.

The rise in gene therapy's prominence is anticipated to drive growth in the in-vitro transcription templates market. Gene therapy involves modifying cellular genes to treat or prevent illnesses by rectifying defective genes. Technological advancements such as CRISPR, substantial investments, and recent treatment successes have heightened interest in this approach. In-vitro transcription templates play a crucial role in gene therapy by providing the necessary RNA molecules for mRNA-based therapies, siRNA-based therapies, and gene editing technologies, enabling the treatment of genetic disorders and diseases. For instance, as of March 2024, the Food and Drug Administration (FDA), a US-based federal agency under the Department of Health and Human Services, reported approving 36 gene therapies, with another 500 in the pipeline. They expect to approve 10-20 annually by 2025, further emphasizing the growing focus on gene therapy driving the in-vitro transcription templates market's expansion.

Key players in the in-vitro transcription templates market are actively developing self-amplifying RNA synthesis services to enhance RNA-based therapy efficiency and effectiveness, reduce production costs, and improve patient outcomes across various therapeutic applications. This technology allows RNA production capable of self-replication within host cells, leading to heightened protein expression from minimal RNA input, thereby improving RNA-based therapy efficiency and effectiveness. For example, in May 2024, GenScript Biotech Corporation, a US-based biotechnology firm, unveiled a self-amplifying RNA (saRNA) synthesis service, expanding its in-vitro transcription RNA synthesis offerings. This new service boosts the potency and efficacy of vaccines, immunotherapies, and gene therapies by enabling robust protein expression from small RNA quantities. The saRNA platform aims to decrease dosages, lower production costs, and enhance patient outcomes, supported by extensive research and development ensuring high purity and improved protein expression.

In September 2022, Lonza, a Switzerland-based pharmaceutical and biotechnology company, partnered with Torchlight to incorporate Touchlight's innovative doggybone DNA (dbDNA) technology into its mRNA development and manufacturing services. This collaboration broadens Lonza's customer offerings, providing faster, scalable, and purer alternatives to traditional plasmid DNA (pDNA) methods, strengthening Lonza's integrated mRNA manufacturing capabilities. Torchlight, a UK-based biotechnology firm, specializes in DNA production and development through an enzymatic process.

Major companies operating in the in-vitro transcription templates market are Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, Eurofins Genomics LLC, Agilent Technologies Inc., Illumina Inc., Bio-Rad Laboratories Inc., Qiagen N.V., Integrated DNA Technologies Inc., Promega Corporation, Genescript Biotech Corporation, Takara Bio Inc., New England Biolabs, OriGene Technologies Inc., Cayman Chemical, Synthego Corporation, Synbio Technologies, Creative Diagnostics, VectorBuilder Inc., Bio-Synthesis Inc., TriLink BioTechnologies, Norgen Biotek Corporation, Genaxxon BioScience GmbH, Enzo Life Sciences Inc., GeneCopoeia.

North America was the largest region in the in-vitro transcription templates market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the in-vitro transcription templates market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the in-vitro transcription templates market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The in-vitro transcription templates market consists of revenues earned by entities by providing services such as RNA synthesis, quality control services, scale-up production, and technical support. The market value includes the value of related goods sold by the service provider or included within the service offering. The in-vitro transcription templates market also includes sales of DNA plasmids, linearized DNA, and synthetic oligonucleotides. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sudden escalation of U.S. tariffs and the resulting trade tensions in spring 2025 are having a significant impact on the pharmaceutical sector. Companies are grappling with higher costs on imported active pharmaceutical ingredients (APIs), glass vials, and laboratory equipment - many of which have limited alternative sources. Generic drug manufacturers, already operating with minimal profit margins, are particularly affected, with some scaling back production of low-margin medications. Biotech firms are also experiencing delays in clinical trials due to shortages of specialized reagents linked to tariffs. In response, the industry is shifting API production to regions like India and Europe, building up inventory reserves, and advocating for tariff exemptions on essential medicines.

The in-vitro transcription templates market research report is one of a series of new reports that provides in-vitro transcription templates market statistics, including the in-vitro transcription templates industry global market size, regional shares, competitors with in-vitro transcription templates market share, detailed in-vitro transcription templates market segments, market trends, and opportunities, and any further data you may need to thrive in the in-vitro transcription templates industry. These in-vitro transcription templates market research reports deliver a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

In-vitro transcription templates are specific DNA sequences crafted to guide RNA synthesis under controlled laboratory conditions. These templates feature designated promoter regions recognized by RNA polymerase, enabling the efficient production of RNA molecules for diverse applications such as research, diagnostic advancements, and therapeutic development. They serve as reliable and precise resources for RNA synthesis, supporting activities in molecular biology and genetic investigations.

The primary applications of in-vitro transcription templates are in vaccine development and therapeutic production. Integral multi-tandem valves represent a category of single-unit valves that consolidate multiple control functions into a compact body. These valves find utility across various research stages including exploratory and clinical phases in treating ailments such as cancer, infectious diseases, lifestyle disorders, genetic conditions, and other medical conditions. They are utilized by pharmaceutical and biotechnology firms, contract research organizations (CROs) and contract manufacturing organizations (CMOs), academic and research institutions, and other relevant entities.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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