Genome Analysis: Principles and Methods provides recent and advanced information about genome analysis approaches and techniques to study and annotate the structure and function of the genome. It is a compendium of important topics such as NGS analysis, genome fragmentation and assembly, metagenomics, cloning and expression, physical marker analysis, transcriptome data analysis, sequence alignment and comparison, evolutionary analysis, SNP analysis, genome-based disease diagnosis and therapies, micro-RNAs, pharmacogenomics, genetic approaches to disease intervention, and challenges with opportunities in genome analysis and genomics, etc.
The latest developments in the field are discussed, and key concepts are introduced to ensure readers understand advanced concepts and methodologies in the area. The book serves as a valuable guide to the present, emerging, and evolving research methodologies in the field.
Table of Contents
1. Introduction to Genome Analysis and Genomics Approaches
2. Genome Complexity and Genome Organization
3. Databases for Genome and Genomic Information
4. Recent Techniques and Strategies for Large-Scale Sequencing
5. Techniques for NGS Data Analysis
6. Genome Fragmentation and Separation Strategies
7. Gene Cloning and Expression Systems
8. Physical Markers and Related Techniques for Marker Development
9. Gene Expression Analysis
10. Computational Approaches for Transcriptome Data Analysis
11. Metagenomics Approaches
12. Sequence Alignment and Comparison Tools
13. Approaches and Tools for Evolutionary Analysis
14. Gene Prediction Approaches
15. SNP Analysis and Related Genetic Disorders
16. Genome Annotation approaches
17. Genome Sequencing Projects and Major Outcomes
18. Human Genome Project and Current Status
19. Comparative Genomics and related Approaches
20. Micro-RNA Prediction Tools and Target Analysis
21. Pharmacogenomics: Current Status and Future Strategies
22. Mechanisms for Genetic Variations
23. Approaches for Genome-based Disease Diagnosis
24. Genetic Approaches to Disease Intervention
25. Challenges and Opportunities in Genome and Genomics Analysis
Authors
Dev Bukhsh Singh Assistant Professor, Department of Biotechnology, Siddharth University, Siddharth Nagar, India. Dr. Dev Bukhsh Singh is currently an Assistant Professor in the Department of Biotechnology at Siddharth University, Kapilvastu, Siddharth Nagar, India since 2021. He also served as Assistant Professor in the Department of Biotechnology at Chhatrapati Shahu Ji Maharaj University, Kanpur, India from 2009-2021. He received BSc (Biology) and MSc from the University of Allahabad, an MTech from the Indian Institute of Information Technology, Prayagraj India, and a PhD in Biotechnology from Gautam Buddha University, India. He has been actively involved in teaching BSc and MSc Biotechnology students since 2009. His areas of research are medicinal biology, lead compound search, and drug design. He published three edited books: Frontiers in Protein Structure, Function, and Dynamics Computer-Aided Drug Design and Bioinformatics: Methods and Applications. He is a member of various national and international academic bodies and is a reviewer for several international journals. Timir Tripathi North-Eastern Hill University.Professor Timir Tripathi is a Professor of Molecular Biology, School of Life Sciences, North-Eastern Hill University, Shillong, India. Earlier, he served as the Regional Director of Indira Gandhi National Open University. His previous role was Senior Assistant Professor and Principal Investigator at the Department of Biochemistry, NEHU, Shillong. He holds a Ph.D. from Jawaharlal Nehru University, New Delhi. His primary research focus is studying the conformational dynamics, interaction, and stabilization of the complexes formed by intrinsically disordered neuropathological protein aggregates, their properties of liquid-liquid phase separation, interaction, and roles in nucleocytoplasmic transport in neurodegenerative diseases. Professor Tripathi is an Associate Fellow of the Indian National Science Academy, New Delhi, and an elected member of the National Academy of Sciences, India, the Royal Society of Chemistry, and the Royal Society of Biology, UK
