Single Molecule Real Time Sequencing Market Report 2025

This single molecule real time sequencing market report delivers an in-depth analysis of the market’s key characteristics, including size, growth potential, and segmentation. It provides a detailed breakdown of the market across major regions and leading countries, highlighting historical data and future growth projections. The report also examines the competitive landscape, market share insights, emerging trends, and strategic developments shaping the market.

The single molecule real time sequencing market size has grown strongly in recent years. It will grow from $3.15 billion in 2024 to $3.43 billion in 2025 at a compound annual growth rate (CAGR) of 8.9%. The growth in the historic period can be attributed to advances in sequencing technologies and reductions in sequencing costs, increased funding and investment in genomics research, growth in personalized medicine and precision healthcare, rising demand for non-invasive diagnostic methods, and expansion of applications in cancer research.

The single molecule real time sequencing market size is expected to see strong growth in the next few years. It will grow to $4.75 billion in 2029 at a compound annual growth rate (CAGR) of 8.5%. The growth in the forecast period can be attributed to continuous technological advancements and innovations in sequencing technologies, increasing adoption of SMRT sequencing for clinical diagnostics and research, growing emphasis on precision medicine and targeted therapies, expansion of genomic research and personalized medicine applications, and rising prevalence of genetic disorders and chronic diseases. Major trends in the forecast period include integration with other omics technologies, miniaturization and portable sequencing, improved data analysis tools, integration with AI and machine learning, and advances in SMRT sequencing technologies.

The increasing occurrence of neurological disorders is anticipated to drive the expansion of the single-molecule real-time sequencing market. Neurological disorders impact the nervous system, which includes the brain, spinal cord, and peripheral nerves, and they can result in various symptoms such as impaired movement, sensation, cognition, and coordination. Examples of these disorders are Alzheimer's disease, Parkinson's disease, stroke, and epilepsy. The growing prevalence of neurological conditions can be linked to factors like an aging population, greater awareness, advancements in diagnostic methods, and environmental influences. Single-molecule real-time (SMRT) sequencing offers in-depth genetic insights that are vital for comprehending and tackling neurological issues. For instance, a report from the Alzheimer's Association, a US-based nonprofit focused on Alzheimer’s disease, indicated that the number of Americans aged 65 and older diagnosed with Alzheimer’s increased from 6.5 million in 2022 to 6.9 million in 2024. Consequently, the rise in neurological disorders is expected to fuel the growth of the single-molecule real-time sequencing market.

Key players in the single-molecule real-time sequencing market are focusing on developing advanced technologies, such as HiFi sequencing, to identify disease-causing genetic mutations in patients. HiFi sequencing technology offers highly accurate, long-read DNA sequences by capturing and analyzing single molecules with minimal errors, providing detailed insights into complex genomic regions. For instance, in October 2022, Pacific Biosciences, a U.S.-based biotechnology company specializing in gene sequencing and real-time biological observation systems, launched the Revio long-read sequencing system. This system significantly scales up HiFi sequencing technology and can sequence up to 1,300 human whole genomes annually at 30-fold coverage for under $1,000 per genome. It features a new SMRT Cell with three times the density of previous models, allowing up to 100 million ZMWs for simultaneous single-molecule sequencing. Enhanced with NVIDIA GPUs and AI-driven algorithms, the system offers a 15-fold increase in HiFi data and a 20-fold improvement in computing power while reducing consumable usage by 50% and improving workflow efficiency by enabling new runs during ongoing ones.

In July 2024, Inqaba Biotec, a biotechnology firm located in South Africa, collaborated with the University of South Africa (UNISA) to introduce Africa's inaugural PacBio Revio sequencing platform. This launch represents a major advancement in the continent's genomic research capabilities. The PacBio Revio platform is intended to improve research by facilitating precise detection of DNA methylation patterns and offering deeper insights into intricate biological processes such as gene regulation, development, and disease progression. The University of South Africa (UNISA) is an institution of higher education in South Africa that provides a diverse array of academic and vocational programs across multiple disciplines.

Major companies operating in the single molecule real time sequencing market are F. Hoffmann-La Roche Ltd, Thermo Fisher Scientific Inc., Agilent Technologies Inc., Illumina Inc., Bio-Rad Laboratories Inc., Qiagen N.V., Tecan Group Ltd, BGI Genomics Co. Ltd., LGC Limited, 10x Genomics Inc., Ginkgo Bioworks Inc., Novogene Corporation, Oxford Nanopore Technologies Limited, New England Biolabs Inc., Pacific Biosciences of California Inc., Horizon Discovery Group plc, Asuragen Inc., GENEWIZ Inc., Bionano Genomics Inc., Zymo Research Corporation, Dovetail Genomics LLC, Singular Genomics Systems Inc.

North America was the largest region in the single molecule real time sequencing market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the single molecule real time sequencing market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the single molecule real time sequencing market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Single-molecule real-time (SMRT) sequencing is a DNA sequencing technology that monitors the synthesis of a single DNA molecule in real-time, enabling long-read sequencing with high precision. This technique utilizes a zero-mode waveguide to detect nucleotide incorporation by a polymerase enzyme, offering detailed and comprehensive genomic data.

The main categories within single-molecule real-time sequencing include pre-sequencing, sequencing, and data analysis. Pre-sequencing encompasses all preparatory steps for sequencing, such as DNA or RNA extraction, purification, and library preparation. The products are classified into consumables, instruments, and services, with applications spanning DNA sequencing, RNA sequencing, epigenetics, whole genome sequencing, and other areas. End users include hospitals, diagnostic laboratories, biopharmaceutical companies, academic institutes and research centers, among others.

The single molecule real time sequencing market research report is one of a series of new reports that provides single molecule real time sequencing market statistics, including single molecule real time sequencing industry global market size, regional shares, competitors with an single molecule real time sequencing market share, detailed single molecule real time sequencing market segments, market trends and opportunities, and any further data you may need to thrive in the single molecule real time sequencing industry. This single molecule real time sequencing market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The single molecule real time sequencing market consists of revenues earned by entities by providing services such as, consulting services, sequencing services, data analysis, training, and support. The market value includes the value of related goods sold by the service provider or included within the service offering. The single molecule real time sequencing market also includes sales of library preparation kits, repair kits, software, and data analysis tools. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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