Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain. Fundamental of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms.
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Table of Contents
Section I An overview about Organoids1. An overview on organoids Past, present and future scenario of organoids
Section II Neurodevelopmental disorder
2. A brief introduction about neurodevelopmental disorders
3. Use of brain organoids for autism
4. Role of brain organoids in Rett Syndrome
5. Brain organoids in bipolar disorder: Unraveling mechanisms and therapeutic approaches
6. Ongoing clinical trials on use of brain organoids for neurodevelopmental disorders
Section III Neurodegenerative diseases
7. An overview of Neurodegenerative diseases
8. Use of brain organoids for Parkinson’s disease and Alzheimer’s disease
9. Application of brain organoids in Huntington’s disease
10. Ongoing clinical trials on use of brain organoids for neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc.)
Section IV Methods involved in organoids development
11. How human-induced pluripotent stem cells are derived into organoids
12. Elements required and days involved in organoid generation
Section V Application and advancement of Brain organoids
13. Brain organoids Challenges while constructing organoids
14. Existing drug targeting and research using brain organoids
Section VI Ethical consideration while conducting organoids research
15. Ethical consideration while conducting organoids research
Section VII Future perspective and concluding remarks
16. Future directions and conclusion
Authors
Balachandar Vellingiri Associate Professor, Neurobiology (Ageing and Pediatric) Laboratory [NAP Lab], Department of Zoology, School of Basic Sciences, Central University of Punjab, Bathinda, Punjab, India.Dr. Balachandar Vellingiri currently is investigating various neurological diseases and developing human induced pluripotent stem cells (HiPSCs). Exploring the cutting-edge molecular, cellular, and translational neuroscience approaches, he aims to unravel disease mechanisms, identify therapeutic targets, and develop innovative interventions to slow or reverse neurological diseases. His expertise is on several techniques such as molecular cytogenetics, pathway analysis, and techniques in developing HiPSCs and Brain organoids, especially for neurological diseases.
Mahalaxmi Balachandar Assistant Professor Department of Community Medicine and Health School of Health Sciences Central University of Punjab, Punjab.Dr. Mahalaxmi Balachandar is currently an Assistant Professor in the Department of Community Medicine and Health, School of Health Sciences, Central University of Punjab, Punjab currently involved in handling neurological disorder patients and conducting genetic and epigenetic studies. Her expertise is in handling bone marrow derived mesenchymal stem cells (BM-MSCs) as a promising therapeutic agent for LHON disease.
