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Depressive and Bipolar Disorders. Diagnosis, Neurobiology, and Therapeutic Innovations

  • Book

  • July 2025
  • Elsevier Science and Technology
  • ID: 6042231
Depressive and Bipolar Disorders: Diagnosis, Neurobiology and Therapeutic Innovations offers a comprehensive reference of affective disorders, providing clinical practitioners with invaluable insights into recognition, diagnosis, and treatment strategies. With a meticulous approach, Dr. V�zquez examines the complexities of major depressive disorder and bipolar disorder, shedding light on the challenges of distinguishing between these conditions, particularly when manic or hypomanic episodes are not readily apparent. Drawing from historical perspectives to the latest DSM criteria, this book offers a thorough examination of depressive disorders, bridging the gap between mood poles and addressing the variability in epidemiology and clinical course. From discussing mixed states and their implications for suicide risk to exploring the neurobiology and genetics underlying mood disorders, this book equips readers with the knowledge needed to navigate the multifaceted nature of affective illnesses. The chapters also provide practical guidance on diagnostic tools, scales for symptom assessment, and pharmacological interventions, emphasizing the importance of precise diagnosis to tailor treatment effectively. With its accessible language and comprehensive coverage, "Depressive and Bipolar Disorders: Diagnosis, Neurobiology and Therapeutic Innovations" is an indispensable resource for healthcare professionals across disciplines, offering insights that can profoundly impact the lives of individuals grappling with these challenging mental health conditions.

Table of Contents

1. Introduction
2. Types of depression
3. Unipolar and bipolar forms of depression
4. The exalted/elated forms
5. The attenuated forms
6. Diagnostic tools
7. Classical neurobiology of affective disorders
8. Recent theories about the neurobiology of major depression
9. Neurobiology of bipolar disorders and mechanisms of action of mood stabilizers drugs
10. Genetics of affective disorders.
11. Suicide and affective disorders
12. Comorbidity with other psychiatric illness.
13. Comorbidity with other medical conditions
14. Pharmacological treatment of major depression
15. The choice of the antidepressant
16. Mood stabilizers
17. Antipsychotics drugs in affective disorders. Beyond the treatment of mania. Clozapine,
18. The refractory depression
19. No-pharmacological treatments
20. Treatment of bipolar disorder

Authors

Gustavo H. Vazquez Professor and Lead, Ketamine Clinic, Mood Disorders Research and Treatment Service, Queen's University Medical School, Department of Psychiatry, Providence Care Hospital, Kingston, ON, Canada. Gustavo H. Vazquez is a Full Professor at the School of Medicine, Queen's University, Director of the CME and staff member of the Mood Disorders Research and Treatment Service, Department of Psychiatry, Providence Care Hospital, Kingston, ON, Canada. He is a member of the Centre for Neuroscience Studies (CNS) at Queen's University (Kingston, Canada), member of the Centre of Neurosicence at Palermo University (Buenos Aires, Argentina) and member of the International Consortium for Psychotic and Bipolar Disorders Research at McLean Hospital, Harvard Medical School (Boston, United States of America).