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Axon Regrowth. The Neurobiology of Nerve and Axon Regeneration

  • Book

  • September 2025
  • Elsevier Science and Technology
  • ID: 6051653
Axon Regrowth: The Neurobiology of Nerve and Axon Regeneration, originally published in 2008 and now fully revised-with a refocus on the central nervous system and axon regeneration-emphasizes the commonalities and differences with peripheral nerve regeneration. The book reviews the substantial problems of axon and nerve regeneration, including molecular mechanisms and the approaches that can be used to experimentally address new avenues. Both researchers and clinicians alike will consider this a valuable resource.

Table of Contents

1. Introduction
2. The intact peripheral nerve tree
3. Injuries and disorders of peripheral nerves (disorder section is new from previous edition)
4. Axonal degeneration (new chapter)
5. Addressing nerve regeneration in vitro and in vivo (in vitro and in vivo is new from previous edition)
6. Growth cones and early regenerative events
7. Growth factors and extrinsic determinants of growth (Formerly Trophic Factors and peripheral nerves)
8. Growth signaling intrinsic pathways within neurons (new chapter)
9. Regeneration and Schwann cell biology (new chapter)
10. Maturation of regeneration and reinnervation
11. Delayed reinnervation
12. Dorsal root ganglia and ganglion stem cells (new chapter)
13. Evaluating experimental neuropathies (new chapter)
14. CNS axon regeneration (new chapter)
15. Nerve repair (new chapter)

Authors

Douglas W Zochodne Neurologist and Neuroscientist, Director of the Neuroscience and Mental Health Institute, University of Alberta, Alberta, Canada. Dr. Douglas Zochodne is a Neurologist and Neuroscientist, Director of the Neuroscience and Mental Health Institute, and Past Divisional Director of Neurology at the University of Alberta (UofA). Dr. Zochodne's career has included faculty positions at Queen's University, Canada, the University of Calgary and more recently the University of Alberta. Dr. Zochodne's roles have included Editor-in-Chief of the Canadian Journal of Neurological Sciences, and President of the Peripheral Nerve Society. He is a Fellow of the Canadian Academy of Health Sciences and his book "Our Wired Nerves: The Human Nerve Connectome� was published in 2020. He has devoted his career toward understanding the biology and diseases of the peripheral nervous system.