Axon Regrowth. The Neurobiology of Nerve and Axon Regeneration

In the second edition of Axon Regrowth: The Neurobiology of Nerve and Axon Regeneration, this comprehensive volume explores the intricate processes of nerve and axon regeneration, addressing one of the most prevalent challenges in neurology. Building on the foundation of the original 2008 publication, this revised edition includes critical new chapters on central nervous system axon regeneration and nerve repair, highlighting both the similarities and differences in regenerative mechanisms between peripheral and central neurons. The book offers an in-depth examination of topics such as axonal degeneration, the biology of Schwann cells, and the role of growth factors and intrinsic signaling pathways. It also discusses the complexities of delayed reinnervation and the potential of dorsal root ganglia and ganglion stem cells in therapeutic approaches. By evaluating experimental neuropathies, this resource provides valuable insights for researchers and clinicians striving to develop effective strategies for nerve repair. With its meticulous review of molecular mechanisms and experimental methodologies, this edition serves as an essential guide for understanding and addressing the challenges of nerve regeneration.

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1. Introduction
2. The intact peripheral nerve tree
3. Injuries and disorders of peripheral nerves (disorder section is new from previous edition)
4. Axonal degeneration (new chapter)
5. Addressing nerve regeneration in vitro and in vivo (in vitro and in vivo is new from previous edition)
6. Growth cones and early regenerative events
7. Growth factors and extrinsic determinants of growth (Formerly Trophic Factors and peripheral nerves)
8. Growth signaling intrinsic pathways within neurons (new chapter)
9. Regeneration and Schwann cell biology (new chapter)
10. Maturation of regeneration and reinnervation
11. Delayed reinnervation
12. Dorsal root ganglia and ganglion stem cells (new chapter)
13. Evaluating experimental neuropathies (new chapter)
14. CNS axon regeneration (new chapter)
15. Nerve repair (new chapter)

Authors

Douglas W Zochodne Neurologist and Neuroscientist, Director of the Neuroscience and Mental Health Institute, University of Alberta, Alberta, Canada. Dr. Douglas Zochodne is a Neurologist and Neuroscientist, Director of the Neuroscience and Mental Health Institute, and Past Divisional Director of Neurology at the University of Alberta (UofA). Dr. Zochodne's career has included faculty positions at Queen's University, Canada, the University of Calgary and more recently the University of Alberta. Dr. Zochodne's roles have included Editor-in-Chief of the Canadian Journal of Neurological Sciences, and President of the Peripheral Nerve Society. He is a Fellow of the Canadian Academy of Health Sciences and his book "Our Wired Nerves: The Human Nerve Connectome� was published in 2020. He has devoted his career toward understanding the biology and diseases of the peripheral nervous system.

Table of Contents

Authors

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