Readers will find advanced transcriptomic technologies, including single-cell and spatial transcriptomics, which unveil the complexities of atherosclerotic disease. The book promises to be a valuable resource for medical professionals seeking to deepen their knowledge in this burgeoning field.
Table of Contents
Section I Introduction1. Atherosclerotic CVD epidemiology and current challenges in management
2. Atherosclerotic Plaque Phenotypes: Unraveling Complexity and Heterogeneity
Section II The role of RNAs in atherosclerosis progression and development
3. Biogenesis and mechanisms of action of ncRNAs
4. The role of ncRNA in plaque development and progression
5. Signaling Pathways Regulating Gene Expression in Atherosclerosis
6. Epitranscriptomics and Atherosclerosis:
Section III Transcriptomic Profiling of Atherosclerotic Lesions
7. Essentials of Transcriptomic Methods: Navigating Through RNA Sequencing and Beyond
8. Bridging the Gap in Transcriptomics: From Animal to Human Studies in Atherosclerosis
9. Translating Transcriptomics into Clinical Practice: Utilizing Gene Expression Patterns for Advanced Patient Phenotyping and Stratification in Atherosclerosis Optimizing Study Design for In-depth Transcriptomic Analysis of Atherosclerotic Plaques
10. Unveiling Sex-Specific Transcriptomic Mechanisms in Atherosclerosis
Section IV Integrating Multi-Omics Approaches in Atherosclerosis Research
11. Combining Transcriptomics with Genomics, Proteomics, and Metabolomics
12. Insights into Gene Regulatory Networks in Vascular Pathology
13. Systems Biology and Network Analysis
14. Use of artificial intelligence and machine learning for multi-omics
Section V RNA-Based Theranostics: Revolutionizing Treatment and Diagnosis in Atherosclerotic Cardiovascular Disease
15. RNA Therapeutics in Atherosclerosis:
16. RNA Therapeutic Delivery Systems advances and challenges
17. Exploring Circulating RNAs: Emerging Biomarkers for Atherosclerosis Detection and Monitoring
Section VI Conclusion
18. Future Directions and Emerging Technologies in Transcriptomic Research and Atherosclerosis
Authors
Yvan Devaux Luxembourg Institute of Health, Luxembourg.Yvan Devaux's main research interest and expertise is the discovery and validation of novel RNA biomarkers and therapeutic targets of brain and heart diseases. As his research focus is translational, he believes that collaboration is key: one of his professional goals is to bring together complementary expertise from clinicians, basic researchers, computational biologists, health economists, social sciences and humanities experts, as well as industrial partners to tackle unmet medical needs.
His research projects are translational and patient-centered. His team has developed and extensively validated biomarker discovery pipelines based on deep sequencing, bioinformatics approaches, complex statistics, artificial intelligence and machine learning. He is acquainted with coordinating large research projects and consortia. His main current focus is the heart-brain axis and RNA biomarkers of cardiovascular and neurological disease.
Miron Sopic Luxembourg Institute of Health, Luxembourg.Miron Sopic, Ph.D., serves as an Associate Professor in the Department of Medical Biochemistry at the University of Belgrade's Faculty of Pharmacy. His educational contributions span a diverse array of subjects, including General Biochemistry, Biostatistics, and Laboratory Diagnostics, highlighting his broad expertise in the field. Sopic's research endeavors are centered on investigating the intricate interactions between inflammation and oxidative stress in cardiometabolic diseases, with a particular focus on identifying and developing novel RNA biomarkers.
His prolific academic output includes more than 41 scientific papers. In 2022, Miron Sopic was honored with the esteemed MSCA Postdoctoral Fellowship, which facilitated his collaboration with Yvan Devaux on researching epitranscriptomic signatures in atherosclerosis at the Cardiovascular Research Unit of the Luxembourg Institute of Health.
