Quantitative Gas Chromatography-Mass Spectrometry: Principles in Life Sciences and Biochemical Applications provides an in-depth exploration of the principles and practices of GC-MS. This comprehensive guide caters to researchers, academics, and graduate students engaged in analytical chemistry, offering both theoretical knowledge and practical applications. The book is structured to introduce the fundamentals before delving into advanced techniques, ensuring a thorough understanding for all readers. The book covers essential topics such as gas chromatography-tandem mass spectrometry, liquid chromatography-tandem mass spectrometry, and the use of stable isotopes and labeled analogs. It also presents practical advice on method development, validation, and quality control.
Additionally, it addresses common issues and troubleshooting in GC-MS, making it a valuable resource for those in fields like Biochemistry, Pharmacology, Forensic Medicine, and Metabolomics.
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Table of Contents
PrefaceAcknowledgements
1. Principles of quantitative analysis by GC-MS, GC-MS/MS and GC-HRMS
2. Extraction and analytical derivatization techniques in GC-MS
3. Quantitative GC-MS analysis of amino acids
4. GC-MS analysis of post-translational modifications
5. Quantitative GC-MS analysis of biogenic amines and polyamines
6. Quantitative GC-MS analysis of drugs
7. Biomedical applications of GC-MS and GC-MS/MS in human studies
8.Perspectives of GC-MS in the life sciences
List of abbreviations used
List of Enzyme Commission (EC) numbers
Subject and Name Index
