The Potential of Intermittent Fasting in Age-related Diseases and Precision Anti-aging Therapeutics takes an in-depth look at the beneficial and efficacious role of Intermittent Fasting (IF) in a wide array of aging-associated diseases. It provides a comprehensive resource that not only outlines the potential benefits and future research directions but also delves into the limitations and nuances of IF in managing these conditions. The book is divided sections and begins by covering the fundamentals of aging and the effects of IF. Subsequent sections examine the physiological impact IF has on aging; its potential influence on stress resistance, heart, gut, and overall health optimization; social and ethical considerations as a therapeutic strategy; bridging IF research findings and clinical practice; and the potential integration and application of IF into age-related diseases treatment. Offering a consolidated and scientifically grounded perspective aimed at equipping readers with a balanced understanding, this book serves as a go-to reference for researchers and clinicians alike seeking clear and accurate insights into how IF can positively influence the health and longevity of the aging population.
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Table of Contents
PART I Fundamentals of aging and intermittent fastingCHAPTER 1 Influence of intermittent fasting on age-related diseases and mechanistic understanding
CHAPTER 2 Role of intermittent fasting, chronobiology, and circadian rhythms in aging and disease
CHAPTER 3 Cellular autophagy and aging: role in intermittent fasting-induced health benefits
PART II Physiological impact of intermittent fasting on aging
CHAPTER 4 Metabolic health and intermittent fasting: implications for age-related disorders
CHAPTER 5 Neurological aging: neuroprotective effects of intermittent fasting
CHAPTER 6 Inflammation, immunity, and intermittent fasting: modulating age-related inflammatory processes
CHAPTER 7 Epigenetic modifications and aging: intermittent fasting as a catalyst for positive epigenetic changes
CHAPTER 8 Mitochondrial health and longevity: intermittent fasting’s impact on cellular energy production
PART III Therapeutic applications of intermittent fasting in aging
CHAPTER 9 Hormesis and adaptive responses: intermittent fasting-induced stress resistance and disease resilience
CHAPTER 10 Intermittent fasting and circadian clocks in cardiovascular aging
CHAPTER 11 Gut microbiota and aging: intermittent fasting’s influence on gut-brain axis and systemic health
CHAPTER 12 Precision nutrition and personalized intermittent fasting: tailoring therapeutics for optimal aging
CHAPTER 13 Translating intermittent fasting research into clinical practice: challenges and opportunities
PART IV Bridging research and practice in intermittent fasting for aging
CHAPTER 14 Future directions in intermittent fasting and aging research: unexplored avenues and collaborative efforts
CHAPTER 15 Interplay between diet, exercise, and intermittent fasting in metabolic disease reduction in people with obesity and promoting healthy aging
CHAPTER 16 The benefits of diet and exercise on delaying heart and brain aging in obesity
CHAPTER 17 Intermittent fasting as complementary therapy in aging-linked diseases
Authors
Abhishek Kumar Singh Associate Professor, Manipal Centre for Biotherapeutics Research (MCBR), Manipal Academy of Higher Education (MAHE), India.Dr. Abhishek Kumar Singh is Associate Professor at Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, India. Dr. Singh obtained his PhD from the CSIR-Indian Institute of Toxicology Research, India, and brings more than a decade of research experience in neurodegeneration and neuroprotection. His research focuses on developing anti-aging strategies targeting autophagy pathways in brain aging and age-related neurodegenerative disorders. Dr. Singh has corresponding teaching experience in biomaterials, bioprocess engineering, and gene therapy.
Jitendra Kumar Sinha Chief Scientific Officer at GloNeuro Academy, Noida and Neuroscience; Visiting Faculty at Jiwaji University, Gwalior, India.Dr. Jitendra Kumar Sinha is a neuroscientist and Associate Professor at the Symbiosis Institute of Health Sciences (SIHS), Symbiosis International (Deemed University), Pune, India. He received his PhD from the ICMR-National Institute of Nutrition and has undertaken internationally collaborative research at institutions in Italy, Australia, and India. With over two decades of experience in research and teaching, his work focuses on the neurobiology of ageing and obesity, nutritional neuroscience, neuropsychiatric disorders, and neuropharmacology. He has made notable contributions to animal models of ageing and epilepsy, particularly in understanding oxidative stress, DNA damage, and biomarkers of accelerated ageing. Dr. Sinha has authored more than 150 research articles and book chapters and actively contributes to the scientific community as an editor and reviewer. He is also deeply engaged in mentoring and academic capacity building.
Affiliations and expertise
Symbiosis Institute of Health Sciences (SIHS), Symbiosis International (Deemed University), India
Raviraja N Seetharam Professor and Head, Manipal Academy of Higher Education, India.Dr. Raviraja Seetharam is Professor and Head of Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, India. Dr. Seetharam obtained his MSc and PhD in Biosciences from Mangalore University, India, and completed post-doctoral research at Mount Allison University, Canada, and Albert Einstein College of Medicine, USA. He brings nearly 30 years of research experience in regenerative medicine, microbiology, and cell and molecular biology. He is a lifetime member of the International Society for Stem Cell Research (ISSCR), USA.
