The Renaissance in GPCR Research and Drug Discovery: Receptor Function, Receptor Structure, New Techniques, Characterization of Drug Activity, Drug Discovery is a comprehensive reference for pharmacology researchers. It focuses on utilizing novel aspects of GPCR function for therapeutic advantage and applying new chemical types to modify GPCR behavior. Recent advancements have revitalized GPCR discovery, opening unexplored avenues for new drug development. The book's content is meticulously divided into five distinct parts, covering evolutionary perspectives, novel functions, investigative technologies, therapeutic modalities, and a broad range of GPCR ligands.
Beyond these key topics, the book delves into the evolution of GPCRs as drug targets, the mechanisms behind their novel functions, and the latest technologies driving research and discovery. It also highlights new and recently approved therapeutic modalities and provides a broad coverage of GPCR ligands. Edited and authored by leading researchers, this book serves as an essential reference for drug discovery researchers and medicinal chemists, as well as AI researchers exploring this drug discovery space.
Beyond these key topics, the book delves into the evolution of GPCRs as drug targets, the mechanisms behind their novel functions, and the latest technologies driving research and discovery. It also highlights new and recently approved therapeutic modalities and provides a broad coverage of GPCR ligands. Edited and authored by leading researchers, this book serves as an essential reference for drug discovery researchers and medicinal chemists, as well as AI researchers exploring this drug discovery space.
Table of Contents
1. Introduction: GPCRs: Past, Present and FutureI. The Evolution of GPCRs as Drug Targets for Therapy
2. GPCRs: From Low Hanging Fruit to Uncharted Territory
3. Orphan GPCRs: New Horizons for GPCR Therapeutics
II. GPCR Mechanisms for Novel Function
4. GPCR Biased Signaling
5. Mechanisms of GPCR Bias and GPCR ‘Decoy Receptors’
6. GPCRs as Nature’s Prototype Allosteric Machine
7. Biasing GPCRs with ligands: expectations and limitations
III. New Technologies to Investigate GPCR Function
8. The Structural Biology Revolution in GPCR Pharmacology
9. Conformational Biosensors / TRUPATH
10. Impact of Conformational Dynamics on GPCR Drug Discovery
11. The kinetics of GPCR signaling and drug action
IV. New Therapeutic Modalities for GPCRs
12. GPCR Mutation and Human Disease
13. GPCR Phenotypic Signaling in Human Stem Cells
V. GPCR Ligands
14. Intracellular GPCR Signaling
15. Antibodies as Drugs for GPCRs
