Metastatic Urothelial Carcinoma Global Market Report 2025

The metastatic urothelial carcinoma market size has grown exponentially in recent years. It will grow from $1.18 billion in 2024 to $1.42 billion in 2025 at a compound annual growth rate (CAGR) of 20.2%. The growth during the historic period can be attributed to a favorable regulatory environment, the rising incidence of smoking-related cancers, the emergence of combination therapies, supportive government policies, and increased awareness and early diagnosis of metastatic urothelial carcinoma.

The metastatic urothelial carcinoma market size is expected to see rapid growth in the next few years. It will grow to $2.94 billion in 2029 at a compound annual growth rate (CAGR) of 19.9%. The growth in the forecast period can be attributed to increased patient advocacy, government programs supporting cancer care, the growth of the biopharmaceutical industry, the rising application of chemotherapy, and rapid urbanization and lifestyle changes. Major trends expected during this period include advancements in immunotherapy, the integration of artificial intelligence, collaborations between pharmaceutical and biotech companies, advancements in telemedicine, and the development of next-generation drugs.

The increasing incidence of bladder cancer is expected to drive the growth of the metastatic urothelial carcinoma market. Bladder cancer is a condition where malignant cells form in the bladder tissues, typically starting in the urothelial cells lining the bladder. The rise in bladder cancer cases is attributed to factors such as smoking, chemical exposure, chronic bladder inflammation, and improvements in detection methods. As metastatic urothelial carcinoma represents an advanced and aggressive stage of bladder cancer, it highlights the critical need for early detection, better treatment options, and increased research, ultimately fostering innovations in the management of bladder cancer and improving patient outcomes. For example, according to a February 2023 report from Cancer Research UK, the number of new bladder cancer cases in the UK is projected to rise from about 9,800 annually between 2023 and 2025 to around 10,700 cases per year by 2038-2040. This growing prevalence of bladder cancer is driving the expansion of the metastatic urothelial carcinoma market.

Regulatory approvals for new treatments are also contributing to the market's growth. Major companies in the metastatic urothelial carcinoma space are obtaining regulatory approvals for drugs, expanding their market reach and reinforcing their position in treating adult patients with locally advanced or metastatic urothelial carcinoma (la/mUC). Regulatory approvals involve the formal authorization granted by governmental bodies for drugs or treatments to be marketed to the public. For example, in April 2023, Merck & Co. Inc., a US-based pharmaceutical company, received FDA approval for KEYTRUDA (pembrolizumab) as a first-line treatment for certain patients with locally advanced or metastatic urothelial cancer. This approval marks a significant step in urothelial cancer treatment, as the combination of KEYTRUDA (pembrolizumab) and enfortumab vedotin became the first anti-PD-1 therapy approved in the U.S. in combination with an antibody-drug conjugate for patients with locally advanced or metastatic urothelial cancer. The combination therapy demonstrated a statistically significant improvement in overall survival (OS) and progression-free survival (PFS) when compared to traditional platinum-based chemotherapy, offering a new option for patients with limited treatment alternatives.

In December 2023, Pfizer Inc., a US-based pharmaceutical company, acquired Seagen Inc. for an undisclosed amount. This acquisition enables Pfizer to enhance its oncology portfolio by integrating Seagen’s innovative antibody-drug conjugate (ADC) technology and expanding its ability to develop targeted cancer therapies. This move strengthens Pfizer’s leadership in cancer treatment and broadens its oncology product pipeline. Seagen, a US-based biotechnology company, specializes in therapies for metastatic urothelial carcinoma.

Major players in the metastatic urothelial carcinoma market are Pfizer Inc., Johnson & Johnson Services Inc., F. Hoffmann-La Roche Ltd., Merck & Co., Inc., AbbVie Inc., Bayer AG, Bayer Aktiengesellschaft, Bristol-Myers Squibb Company, AstraZeneca PLC, Eli Lilly and Company, Gilead Sciences Inc., Merck KGaA, Astellas Pharma Inc., Genentech Inc., Genentech Inc., Exelixis Inc., EMD Serono, Zymeworks Inc., Mirati Therapeutics Inc., UroGen Pharma Ltd.

North America was the largest region in the metastatic urothelial carcinoma market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in metastatic urothelial carcinoma report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the metastatic urothelial carcinoma market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Metastatic urothelial carcinoma is an advanced form of bladder cancer where the cancer has spread beyond the urothelium to distant organs or lymph nodes. Treatment for metastatic urothelial carcinoma involves advanced diagnostic technologies, targeted therapies, and immunotherapies to manage and treat cancer that has spread beyond the bladder or urinary tract.

The primary treatment options for metastatic urothelial carcinoma include chemotherapy, targeted therapy, immunotherapy, radiation therapy, and intravesical therapy. Chemotherapy uses drugs to kill cancer cells or inhibit their growth. Diagnostic methods for detecting this cancer include urine lab tests, cystoscopy, intravenous pyelogram (IVP), and biopsy. Treatments can include medications, lifestyle changes, and other therapies, with administration routes such as oral, parenteral, and others. These treatments are utilized in various settings, including hospitals, oncology clinics, research institutes, and other healthcare facilities.

The metastatic urothelial carcinoma market research report is one of a series of new reports that provides metastatic urothelial carcinoma market statistics, including metastatic urothelial carcinoma industry global market size, regional shares, competitors with a metastatic urothelial carcinoma market share, detailed metastatic urothelial carcinoma market segments, market trends and opportunities, and any further data you may need to thrive in the metastatic urothelial carcinoma industry. This metastatic urothelial carcinoma market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The metastatic urothelial carcinoma market consists of revenues earned by entities by providing services such as sales of surgical treatment, combination therapy and supportive care. The market value includes the value of related goods sold by the service provider or included within the service offering. The metastatic urothelial carcinoma market also includes sales of chemotherapy agents, immunotherapy drugs, tyrosine kinase inhibitors, adjuvant treatments, and targeted therapies. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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