Hutchinson-Gilford Progeria Syndrome (HGPS) Global Market Report 2025

The hutchinson-gilford progeria syndrome (HGPS) market size has grown strongly in recent years. It will grow from $97.63 billion in 2024 to $106.56 billion in 2025 at a compound annual growth rate (CAGR) of 9.1%. The growth during the historic period can be attributed to increased awareness of rare genetic disorders, greater funding for progeria research, the expansion of genetic testing, rising government initiatives for rare diseases, and the growing global prevalence of genetic disorders.

The hutchinson-gilford progeria syndrome (HGPS) market size is expected to see strong growth in the next few years. It will grow to $149.22 billion in 2029 at a compound annual growth rate (CAGR) of 8.8%. The projected growth in the forecast period is driven by increased funding for research and the development of new therapies, a rising prevalence of progeria, higher global healthcare expenditure, the adoption of novel therapeutic approaches, and a growing demand for early diagnosis. Key trends expected in this period include technological advancements, the development of targeted therapies, improvements in next-generation sequencing (NGS) technologies, the identification of biomarkers, and advancements in drug delivery systems.

The rise in funding for research and development of new therapies is expected to drive the growth of the Hutchinson-Gilford Progeria Syndrome (HGPS) market. Research and development funding refers to financial resources allocated to fostering innovation, enhancing scientific knowledge, and advancing technological solutions. The increase in such funding is attributed to factors such as the growing demand for innovative treatments and government support for healthcare advancements. Greater investment in research and development accelerates progress in treating Hutchinson-Gilford Progeria Syndrome by supporting clinical trials and promoting the development of novel therapies. It also advances the understanding of the genetic origins of the disease and enables the creation of targeted solutions. For example, in April 2024, the Office for National Statistics, a UK-based government agency, reported that in 2022, the UK government's net expenditure on research and development (R&D) increased by 10.5%, reaching £15.5 billion ($17.59 billion), up from £14 billion ($15.88 billion) in 2021. As a result, increased funding for research and development is contributing to the growth of the Hutchinson-Gilford Progeria Syndrome (HGPS) market.

Leading companies in the Hutchinson-Gilford Progeria Syndrome (HGPS) market are prioritizing the development of advanced farnesyltransferase inhibitors to enhance treatment effectiveness and slow disease progression in affected patients. Farnesyltransferase inhibitors are drugs that block farnesyltransferase, an enzyme responsible for protein modification, helping prevent abnormal cell growth and aging. For instance, in July 2022, Eiger BioPharmaceuticals, a US-based biopharmaceutical company, received marketing authorization from the European Commission for Zokinvy, making it the first and only approved treatment in Europe for Hutchinson-Gilford Progeria Syndrome (HGPS) and processing-deficient progeroid laminopathies (PL) in children and young adults. Zokinvy, an oral disease-modifying agent, demonstrated a 72% reduction in mortality risk and an average life extension of 4.3 years in clinical trials. The European Commission’s centralized authorization applies across all 27 EU member states as well as Iceland, Liechtenstein, and Norway.

In May 2024, Sentynl Therapeutics, Inc., a US-based biopharmaceutical company, acquired Zokinvy from Eiger BioPharmaceuticals, Inc. for an undisclosed amount. Through this acquisition, Sentynl aims to address the unmet medical needs of patients suffering from ultra-rare genetic conditions that cause accelerated aging and significantly shorten life expectancy. Eiger BioPharmaceuticals, Inc., a US-based biopharmaceutical company, originally developed Zokinvy (lonafarnib) for the treatment of Hutchinson-Gilford Progeria Syndrome (HGPS).

Major players in the hutchinson-gilford progeria syndrome (hgps) market are National Institutes of Health (NIH), Mount Sinai, Johns Hopkins Hospital, Duke University, Mayo Foundation for Medical Education and Research, Cleveland Clinic, Children's Hospital of Philadelphia, St. Jude Children's Research Hospital, Cincinnati Children's Hospital Medical Center, University of Maryland, Boston Children's Hospital, Children’s Hospital Los Angeles, Harvard Medical School, The Scripps Research Institute, Blueprint Genetics, Medicover Hospitals, Sentynl Therapeutics, UCSF Helen Diller Family Comprehensive Cancer Center, Progeria Research Foundation, AnGes MG Inc., and PRG Science & Technology Co. Ltd.

North America was the largest region in the hutchinson-gilford progeria syndrome (HGPS) market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in hutchinson-gilford progeria syndrome (HGPS) report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the hutchinson-gilford progeria syndrome (HGPS) market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Hutchinson-Gilford Progeria Syndrome (HGPS), commonly known as progeria, is an extremely rare and fatal genetic condition that causes rapid aging in children. It is triggered by mutations in the LMNA gene, resulting in symptoms such as growth delays, hair loss, premature skin wrinkling, and cardiovascular complications. The average life expectancy of individuals with progeria is around 14.5 years.

The primary treatments for Hutchinson-Gilford Progeria Syndrome (HGPS) include farnesyltransferase inhibitors (such as Zokinvy (lonafarnib)), low-dose aspirin, physical and occupational therapy, hearing aids, genetic counseling, and other supportive therapies. Farnesyltransferase inhibitors such as Zokinvy (lonafarnib) work by blocking the enzyme responsible for protein modification, providing a targeted treatment that may help slow premature aging in affected children. These treatments are administered through various methods, including oral, injectable, intravenous, and transdermal routes, utilizing mechanisms such as antisense oligonucleotides, CRISPR-Cas9 gene editing, RNA interference, and targeted drug delivery systems. The treatment is utilized across multiple healthcare settings, including hospitals, specialty clinics, academic and research institutes, and other medical facilities.

The hutchinson-gilford progeria syndrome (HGPS) market research report is one of a series of new reports that provides hutchinson-gilford progeria syndrome (HGPS) market statistics, including the hutchinson-gilford progeria syndrome (HGPS) industry global market size, regional shares, competitors with the hutchinson-gilford progeria syndrome (HGPS) market share, detailed hutchinson-gilford progeria syndrome (HGPS) market segments, market trends, and opportunities, and any further data you may need to thrive in the hutchinson-gilford progeria syndrome (HGPS) industry. This hutchinson-gilford progeria syndrome (HGPS) market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The hutchinson-gilford progeria syndrome (HGPS) market consists of revenues earned by entities by providing services such as genetic testing and diagnosis, drug development and clinical trials, specialized medical care and treatment, and patient support and counseling services. The market value includes the value of related goods sold by the service provider or included within the service offering. The hutchinson-gilford progeria syndrome (HGPS) market also includes sales of pharmaceutical drugs, genetic testing kits, medical devices and monitoring equipment, nutritional supplements and special diet products, and assistive mobility devices. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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