RNAi Technology - Global Strategic Business Report

The global market for RNAi Technology was valued at US$2.9 Billion in 2024 and is projected to reach US$7.0 Billion by 2030, growing at a CAGR of 15.6% from 2024 to 2030. This comprehensive report provides an in-depth analysis of market trends, drivers, and forecasts, helping you make informed business decisions. The report includes the most recent global tariff developments and how they impact the RNAi Technology market.

Global “RNAi Technology” Market - Key Trends & Drivers Summarized

How Is RNAi Technology Redefining the Landscape of Precision Medicine?

RNA interference (RNAi) technology has rapidly emerged as a transformative tool in biomedical science, enabling highly specific gene silencing to modulate disease-related protein expression. By utilizing small interfering RNA (siRNA) and microRNA (miRNA) to inhibit mRNA translation, RNAi offers a mechanism to therapeutically target previously 'undruggable' genes. Its precision in selectively shutting down aberrant gene expression has made it a cornerstone in next-generation therapeutic platforms, particularly for genetic disorders, cancers, and viral infections. The approval of RNAi-based drugs such as patisiran and givosiran by regulatory bodies like the FDA and EMA has validated the clinical potential of this modality. Growing interest in rare disease treatment is amplifying RNAi’s importance, as these conditions often arise from single-gene mutations. Furthermore, advances in lipid nanoparticle (LNP) and GalNAc-conjugated delivery systems have enhanced RNAi bioavailability and safety, enabling effective liver-targeted therapies. Pharmaceutical companies are increasing their RNAi R&D investments, supported by growing partnerships between biotech startups and big pharma. With ongoing success in clinical trials for conditions like hypercholesterolemia, amyloidosis, and hemophilia, RNAi is quickly expanding from experimental status to mainstream biopharmaceutical application.

What Are the Technological Bottlenecks and Innovations in RNAi Delivery?

The efficiency and specificity of RNAi therapy hinge critically on its delivery to target cells and tissues - a longstanding challenge in the field. Traditional delivery approaches faced degradation issues in the bloodstream and off-target effects, limiting clinical viability. However, the advent of LNPs, GalNAc conjugates, and polymer-based systems has revolutionized RNAi transport, allowing for organ-specific uptake and reduced immune activation. Liver-targeted delivery remains the most advanced, with GalNAc-siRNA conjugates showing significant promise in treating hepatic diseases. Researchers are now extending delivery capabilities to non-hepatic tissues, such as the central nervous system and lungs, using advanced carriers like dendrimers, exosomes, and aptamers. The integration of AI and machine learning in designing optimal siRNA sequences is also streamlining the discovery pipeline by predicting off-target risks and improving stability. In parallel, chemical modification strategies - such as 2'-O-methyl and phosphorothioate backbones - are enhancing siRNA half-life and cellular uptake. The miniaturization of high-throughput screening platforms and use of CRISPR-based analytics are accelerating validation of RNAi targets. While immunogenicity and scalability remain ongoing concerns, technological convergence is steadily dismantling these barriers, moving RNAi into broader clinical and commercial application.

Which Sectors Are Driving the Proliferation of RNAi Applications?

While healthcare remains the primary domain for RNAi deployment, its applications are growing across several other sectors. In human therapeutics, RNAi is being developed to treat a range of genetic, metabolic, and infectious diseases. Oncology is emerging as a significant field of interest, with efforts to silence genes involved in tumor growth, metastasis, and drug resistance. Agricultural biotechnology is leveraging RNAi for crop protection, using gene silencing to confer resistance against pests, viruses, and fungal pathogens without introducing foreign proteins. Animal health applications are also expanding, including RNAi-based vaccines and treatments for zoonotic diseases. RNAi is further being explored in antiviral defense, especially for RNA viruses such as SARS-CoV-2, influenza, and hepatitis B. Research organizations and universities are employing RNAi in functional genomics to decode gene function at scale. Environmental monitoring is another emerging niche, where RNAi is used to detect or control invasive species through species-specific gene targeting. These cross-sectoral applications are fueling market growth and spurring interdisciplinary collaborations. The need for novel, sustainable, and precision-targeted interventions across industries underscores the foundational importance of RNAi in future innovation.

The Growth in the RNAi Technology Market Is Driven by Several Factors

The RNAi technology market is witnessing rapid growth driven by a unique mix of therapeutic demand, regulatory advancements, and platform scalability. The increasing burden of rare and chronic diseases, coupled with a need for highly targeted therapies, is creating strong clinical demand for RNAi-based solutions. The success of early RNAi therapeutics has generated regulatory confidence, expediting the approval process and attracting greater venture capital investment. Improvements in RNA chemistry and delivery systems are expanding the spectrum of treatable conditions, especially those involving hepatic, cardiovascular, and oncological pathways. Pharmaceutical companies are leveraging RNAi to complement or replace traditional small molecules in complex disease targets. Additionally, governments and public health bodies are investing in RNAi for pandemic preparedness and next-generation vaccine platforms. Agricultural and environmental use cases are gaining traction due to the need for pesticide alternatives and ecologically safe pest control. Academic partnerships and open-source genome libraries are facilitating rapid innovation in target discovery and validation. Moreover, advancements in AI for sequence optimization and delivery prediction are improving cost-efficiency and development speed. Collectively, these factors are positioning RNAi as a disruptive force across therapeutic, agricultural, and environmental biotech landscapes.

Report Scope

The report analyzes the RNAi Technology market, presented in terms of market value (US$ Thousand). The analysis covers the key segments and geographic regions outlined below.

Segments: Application (Drug Discovery & Development, Therapeutics, Functional Genomics, Other Applications); End-User (Pharma & Biotech Companies, Academic & Research Institutes, CROs & CMOs, Other End-Users).

Geographic Regions/Countries: World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; and Rest of Europe); Asia-Pacific; Rest of World.

Key Insights:

• Market Growth: Understand the significant growth trajectory of the Drug Discovery & Development Application segment, which is expected to reach US$3.6 Billion by 2030 with a CAGR of a 18.8%. The Therapeutics Application segment is also set to grow at 12.1% CAGR over the analysis period.
• Regional Analysis: Gain insights into the U.S. market, valued at $767.6 Million in 2024, and China, forecasted to grow at an impressive 14.6% CAGR to reach $1.1 Billion by 2030. Discover growth trends in other key regions, including Japan, Canada, Germany, and the Asia-Pacific.

Why You Should Buy This Report:

• Detailed Market Analysis: Access a thorough analysis of the Global RNAi Technology Market, covering all major geographic regions and market segments.
• Competitive Insights: Get an overview of the competitive landscape, including the market presence of major players across different geographies.
• Future Trends and Drivers: Understand the key trends and drivers shaping the future of the Global RNAi Technology Market.
• Actionable Insights: Benefit from actionable insights that can help you identify new revenue opportunities and make strategic business decisions.

Key Questions Answered:

• How is the Global RNAi Technology Market expected to evolve by 2030?
• What are the main drivers and restraints affecting the market?
• Which market segments will grow the most over the forecast period?
• How will market shares for different regions and segments change by 2030?
• Who are the leading players in the market, and what are their prospects?

Report Features:

• Comprehensive Market Data: Independent analysis of annual sales and market forecasts in US$ Million from 2024 to 2030.
• In-Depth Regional Analysis: Detailed insights into key markets, including the U.S., China, Japan, Canada, Europe, Asia-Pacific, Latin America, Middle East, and Africa.
• Company Profiles: Coverage of players such as Alnylam Pharmaceuticals, Arbutus Biopharma Corporation, Arcturus Therapeutics, Arrowhead Pharmaceuticals, AstraZeneca and more.
• Complimentary Updates: Receive free report updates for one year to keep you informed of the latest market developments.

Some of the 34 companies featured in this RNAi Technology market report include:

• Alnylam Pharmaceuticals
• Arbutus Biopharma Corporation
• Arcturus Therapeutics
• Arrowhead Pharmaceuticals
• AstraZeneca
• Benitec Biopharma
• Dicerna Pharmaceuticals
• F. Hoffmann-La Roche Ltd.
• GlaxoSmithKline plc
• Ionis Pharmaceuticals
• Merck & Co., Inc.
• Moderna, Inc.
• Novartis AG
• OLIX Pharmaceuticals, Inc.
• Phio Pharmaceuticals Corp.
• ProQR Therapeutics
• Qiagen N.V.
• Quark Pharmaceuticals, Inc.
• Sanofi
• Silence Therapeutics PLC

Tariff Impact Analysis: Key Insights for 2025

Global tariff negotiations across 180+ countries are reshaping supply chains, costs, and competitiveness. This report reflects the latest developments as of April 2025 and incorporates forward-looking insights into the market outlook.

The analysts continuously track trade developments worldwide, drawing insights from leading global economists and over 200 industry and policy institutions, including think tanks, trade organizations, and national economic advisory bodies. This intelligence is integrated into forecasting models to provide timely, data-driven analysis of emerging risks and opportunities.

What's Included in This Edition:

• Tariff-adjusted market forecasts by region and segment
• Analysis of cost and supply chain implications by sourcing and trade exposure
• Strategic insights into geographic shifts

Buyers receive a free July 2025 update with:

• Finalized tariff impacts and new trade agreement effects
• Updated projections reflecting global sourcing and cost shifts
• Expanded country-specific coverage across the industry