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Insulin Sensitizers - Global Strategic Business Report

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    Report

  • 340 Pages
  • June 2025
  • Region: Global
  • Global Industry Analysts, Inc
  • ID: 6089468
The global market for Insulin Sensitizers was estimated at US$21.7 Billion in 2024 and is projected to reach US$28.8 Billion by 2030, growing at a CAGR of 4.8% from 2024 to 2030. This comprehensive report provides an in-depth analysis of market trends, drivers, and forecasts, helping you make informed business decisions. The report includes the most recent global tariff developments and how they impact the Insulin Sensitizers market.

Global Insulin Sensitizers Market - Key Trends & Drivers Summarized

Why Are Insulin Sensitizers Central to the Management of Type 2 Diabetes and Metabolic Disorders?

Insulin sensitizers are a critical class of therapeutic agents designed to enhance the body's response to insulin, thereby improving glucose uptake and utilization in individuals with insulin resistance a hallmark of type 2 diabetes and metabolic syndrome. Unlike insulin or insulin secretagogues, which directly affect insulin levels, insulin sensitizers act on peripheral tissues such as muscle, liver, and adipose tissue to restore insulin sensitivity and improve glycemic control without stimulating endogenous insulin secretion. This mechanism reduces the risk of hypoglycemia while addressing one of the root causes of metabolic dysfunction.

These drugs are widely used as part of first- or second-line treatment strategies, particularly in patients with obesity-related insulin resistance. They are also increasingly considered in the management of polycystic ovary syndrome (PCOS), non-alcoholic fatty liver disease (NAFLD), and prediabetes. By improving insulin action and reducing hepatic glucose output, insulin sensitizers help lower fasting plasma glucose, hemoglobin A1c levels, and associated cardiometabolic risks. Their role in long-term disease modulation makes them indispensable in the broader landscape of chronic metabolic care.

What Pharmacological Classes and Innovations Are Reshaping Insulin Sensitizer Therapies?

The insulin sensitizer category is largely represented by two major drug classes:thiazolidinediones (TZDs)andbiguanides, with metformin being the most widely prescribed agent worldwide. Metformin, often considered the cornerstone of type 2 diabetes management, primarily acts by decreasing hepatic glucose production and improving peripheral insulin sensitivity. It is favored for its well-established efficacy, safety, weight neutrality, and cardiovascular benefits.

Thiazolidinediones, such as pioglitazone and rosiglitazone, function by activating peroxisome proliferator-activated receptor gamma (PPAR-γ), leading to enhanced insulin responsiveness in adipose tissue and skeletal muscle. While effective, their use is moderated due to concerns around fluid retention, bone fractures, and cardiovascular risk. However, ongoing research into selective PPAR modulators and dual PPAR-α/γ agonists aims to retain the glucose-lowering benefits of TZDs while minimizing adverse effects.

Emerging insulin sensitizer candidates include AMP-activated protein kinase (AMPK) activators, mitochondrial function modulators, and agents targeting inflammation and lipid metabolism. Research is also exploring plant-derived bioactives and gut microbiome modulators for their potential to improve insulin action through novel biological pathways. The development of fixed-dose combinations with SGLT2 inhibitors, GLP-1 receptor agonists, and DPP-4 inhibitors is further enhancing therapeutic versatility and patient adherence.

Which Patient Populations and Clinical Trends Are Driving Demand for Insulin Sensitizers?

The primary driver of insulin sensitizer use is the global surge in type 2 diabetes and insulin resistance, particularly among aging populations, individuals with obesity, and populations experiencing urbanization and sedentary lifestyles. The demand is especially strong in regions experiencing rapid epidemiological transitions, where lifestyle-related metabolic disorders are rising sharply. In newly diagnosed diabetic patients, insulin sensitizers especially metformin are widely adopted as first-line therapy due to their cost-effectiveness and favorable risk-benefit profile.

In women's health, insulin sensitizers are frequently prescribed for PCOS, where insulin resistance contributes to menstrual irregularities, hyperandrogenism, and subfertility. Additionally, they are gaining traction in managing NAFLD and metabolic-associated fatty liver disease (MAFLD), given their ability to reduce hepatic steatosis and improve liver enzyme profiles. In prediabetic individuals, metformin is increasingly used as a preventive therapy, especially in patients with high BMI and impaired fasting glucose. These overlapping indications are expanding the role of insulin sensitizers beyond glucose control to broader metabolic optimization.

The Growth in the Insulin Sensitizers Market Is Driven by Several Factors…

The growth in the insulin sensitizers market is driven by several factors including the escalating global burden of type 2 diabetes, expanding off-label therapeutic applications, and ongoing efforts to develop next-generation agents with improved safety profiles. Rising public health awareness, early diagnosis initiatives, and updated treatment guidelines that recommend early intervention in insulin resistance are increasing patient volumes and prescription rates. The continued endorsement of metformin in international diabetes management protocols also ensures its dominance and sustained demand.

Pharmaceutical innovation is accelerating with the development of new molecular targets, combination therapies, and personalized dosing strategies. Real-world evidence supporting the long-term cardioprotective and metabolic benefits of insulin sensitizers is reinforcing their clinical relevance in comprehensive diabetes care. Additionally, growing investment in obesity and metabolic syndrome therapeutics is boosting R&D around novel sensitizers and repositioning existing agents for expanded indications. As healthcare systems aim to delay disease progression, minimize complications, and reduce the economic burden of diabetes, insulin sensitizers are poised to remain a foundational component of metabolic disorder management worldwide.

Key Insights:

  • Market Growth: Understand the significant growth trajectory of the Thiazolidinediones segment, which is expected to reach US$13.1 Billion by 2030 with a CAGR of a 3.8%. The Biguanides segment is also set to grow at 6.5% CAGR over the analysis period.
  • Regional Analysis: Gain insights into the U.S. market, valued at $5.9 Billion in 2024, and China, forecasted to grow at an impressive 7.5% CAGR to reach $5.6 Billion by 2030. Discover growth trends in other key regions, including Japan, Canada, Germany, and the Asia-Pacific.

Why You Should Buy This Report:

  • Detailed Market Analysis: Access a thorough analysis of the Global Insulin Sensitizers Market, covering all major geographic regions and market segments.
  • Competitive Insights: Get an overview of the competitive landscape, including the market presence of major players across different geographies.
  • Future Trends and Drivers: Understand the key trends and drivers shaping the future of the Global Insulin Sensitizers Market.
  • Actionable Insights: Benefit from actionable insights that can help you identify new revenue opportunities and make strategic business decisions.

Key Questions Answered:

  • How is the Global Insulin Sensitizers Market expected to evolve by 2030?
  • What are the main drivers and restraints affecting the market?
  • Which market segments will grow the most over the forecast period?
  • How will market shares for different regions and segments change by 2030?
  • Who are the leading players in the market, and what are their prospects?

Report Features:

  • Comprehensive Market Data: Independent analysis of annual sales and market forecasts in US$ Million from 2024 to 2030.
  • In-Depth Regional Analysis: Detailed insights into key markets, including the U.S., China, Japan, Canada, Europe, Asia-Pacific, Latin America, Middle East, and Africa.
  • Company Profiles: Coverage of players such as Amgen Inc., AstraZeneca, Biocon Limited, Boehringer Ingelheim, and more.
  • Complimentary Updates: Receive free report updates for one year to keep you informed of the latest market developments.

Some of the 44 companies featured in this Insulin Sensitizers market report include:

  • Amgen Inc.
  • AstraZeneca
  • Biocon Limited
  • Boehringer Ingelheim
  • Bristol Myers Squibb
  • Chong Kun Dang Pharmaceutical Corp.
  • Eli Lilly and Company
  • Fractyl Health
  • Gan & Lee Pharmaceuticals
  • GSK (GlaxoSmithKline)
  • Imcyse
  • Ionis Pharmaceuticals
  • Johnson & Johnson
  • Merck & Co., Inc.
  • MSDC-0602K (Cirius Therapeutics)
  • Novo Nordisk
  • Sanofi
  • Saroglitazar
  • Takeda Pharmaceutical Company
  • Zydus Lifesciences

This edition integrates the latest global trade and economic shifts as of June 2025 into comprehensive market analysis. Key updates include:

  • Tariff and Trade Impact: Insights into global tariff negotiations across 180+ countries, with analysis of supply chain turbulence, sourcing disruptions, and geographic realignment. Special focus on 2025 as a pivotal year for trade tensions, including updated perspectives on the Trump-era tariffs.
  • Adjusted Forecasts and Analytics: Revised global and regional market forecasts through 2030, incorporating tariff effects, economic uncertainty, and structural changes in globalization. Includes segmentation by product, technology, type, material, distribution channel, application, and end-use, with historical analysis since 2015.
  • Strategic Market Dynamics: Evaluation of revised market prospects, regional outlooks, and key economic indicators such as population and urbanization trends.
  • Innovation & Technology Trends: Latest developments in product and process innovation, emerging technologies, and key industry drivers shaping the competitive landscape.
  • Competitive Intelligence: Updated global market share estimates for 2025, competitive positioning of major players (Strong/Active/Niche/Trivial), and refined focus on leading global brands and core players.
  • Expert Insight & Commentary: Strategic analysis from economists, trade experts, and domain specialists to contextualize market shifts and identify emerging opportunities.
  • Complimentary Update: Buyers receive a free July 2025 update with finalized tariff impacts, new trade agreement effects, revised projections, and expanded country-level coverage.

Table of Contents

I. METHODOLOGYII. EXECUTIVE SUMMARY
1. MARKET OVERVIEW
  • Influencer Market Insights
  • World Market Trajectories
  • Tariff Impact on Global Supply Chain Patterns
  • Insulin Sensitizers - Global Key Competitors Percentage Market Share in 2025 (E)
  • Competitive Market Presence - Strong/Active/Niche/Trivial for Players Worldwide in 2025 (E)
2. FOCUS ON SELECT PLAYERS
3. MARKET TRENDS & DRIVERS
  • Rising Global Prevalence of Type 2 Diabetes Propels Demand for Insulin Sensitizers as a Core Therapeutic Class
  • Shift Toward Early Intervention and Combination Therapy Strengthens Use of Insulin Sensitizers Alongside GLP-1 and SGLT2 Inhibitors
  • Increasing Clinical Focus on Metabolic Syndrome and Insulin Resistance Expands Off-Label and Adjunctive Use of Sensitizing Agents
  • Ongoing Development of Next-Generation Thiazolidinediones (TZDs) With Reduced Side Effects Drives Pipeline Innovation
  • Growing Emphasis on Personalized Medicine in Diabetes Care Spurs Interest in Pharmacogenomics-Guided Insulin Sensitizer Therapies
  • Rising Incidence of Obesity-Linked Diabetes Highlights the Role of Insulin Sensitizers in Improving Adipose Tissue Sensitivity
  • Emergence of Dual and Triple Mechanism Therapies Encourages Integration of Insulin Sensitizers With Incretin-Based Agents
  • Increasing Research Into PCOS and NAFLD Expands Therapeutic Use Cases for Metformin and TZD-Class Sensitizers
  • Declining Cost of Generic Metformin Sustains Widespread First-Line Adoption in Low- and Middle-Income Countries
  • Regulatory Push for Safer Diabetic Medications Promotes Reformulation of Older TZDs With Improved Safety Profiles
  • Pharmaceutical Investment in Oral Antidiabetic Combinations Enhances Commercial Viability of Insulin Sensitizer Co-Formulations
4. GLOBAL MARKET PERSPECTIVE
  • TABLE 1: World Insulin Sensitizers Market Analysis of Annual Sales in US$ Million for Years 2015 through 2030
  • TABLE 2: World Recent Past, Current & Future Analysis for Insulin Sensitizers by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 3: World 6-Year Perspective for Insulin Sensitizers by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets for Years 2025 & 2030
  • TABLE 4: World Recent Past, Current & Future Analysis for Thiazolidinediones by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 5: World 6-Year Perspective for Thiazolidinediones by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 6: World Recent Past, Current & Future Analysis for Biguanides by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 7: World 6-Year Perspective for Biguanides by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 8: World Recent Past, Current & Future Analysis for Incretin-based Therapies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 9: World 6-Year Perspective for Incretin-based Therapies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 10: World Recent Past, Current & Future Analysis for Other Insulin Sensitizers by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 11: World 6-Year Perspective for Other Insulin Sensitizers by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 12: World Recent Past, Current & Future Analysis for Hospital Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 13: World 6-Year Perspective for Hospital Pharmacies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 14: World Recent Past, Current & Future Analysis for Retail Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 15: World 6-Year Perspective for Retail Pharmacies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 16: World Recent Past, Current & Future Analysis for Online Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 17: World 6-Year Perspective for Online Pharmacies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 18: World Recent Past, Current & Future Analysis for Type 2 Diabetes by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 19: World 6-Year Perspective for Type 2 Diabetes by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 20: World Recent Past, Current & Future Analysis for Prediabetes by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 21: World 6-Year Perspective for Prediabetes by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 22: World Recent Past, Current & Future Analysis for Polycystic Ovary Syndrome by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 23: World 6-Year Perspective for Polycystic Ovary Syndrome by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 24: World Recent Past, Current & Future Analysis for Oral by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 25: World 6-Year Perspective for Oral by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
  • TABLE 26: World Recent Past, Current & Future Analysis for Injectable by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 27: World 6-Year Perspective for Injectable by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2025 & 2030
III. MARKET ANALYSIS
UNITED STATES
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in the United States for 2025 (E)
CANADA
JAPAN
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Japan for 2025 (E)
CHINA
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in China for 2025 (E)
EUROPE
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Europe for 2025 (E)
FRANCE
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in France for 2025 (E)
GERMANY
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Germany for 2025 (E)
ITALY
UNITED KINGDOM
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in the United Kingdom for 2025 (E)
SPAINRUSSIAREST OF EUROPE
ASIA-PACIFIC
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Asia-Pacific for 2025 (E)
AUSTRALIA
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Australia for 2025 (E)
INDIA
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in India for 2025 (E)
SOUTH KOREAREST OF ASIA-PACIFIC
LATIN AMERICA
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Latin America for 2025 (E)
ARGENTINABRAZILMEXICOREST OF LATIN AMERICA
MIDDLE EAST
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Middle East for 2025 (E)
IRANISRAELSAUDI ARABIAUNITED ARAB EMIRATESREST OF MIDDLE EAST
AFRICA
  • Insulin Sensitizers Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Africa for 2025 (E)
IV. COMPETITION

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • Amgen Inc.
  • AstraZeneca
  • Biocon Limited
  • Boehringer Ingelheim
  • Bristol Myers Squibb
  • Chong Kun Dang Pharmaceutical Corp.
  • Eli Lilly and Company
  • Fractyl Health
  • Gan & Lee Pharmaceuticals
  • GSK (GlaxoSmithKline)
  • Imcyse
  • Ionis Pharmaceuticals
  • Johnson & Johnson
  • Merck & Co., Inc.
  • MSDC-0602K (Cirius Therapeutics)
  • Novo Nordisk
  • Sanofi
  • Saroglitazar
  • Takeda Pharmaceutical Company
  • Zydus Lifesciences

Table Information