Protein Crystallization Market Report 2025

The protein crystallization market size has grown rapidly in recent years. It will grow from $1.62 billion in 2024 to $1.82 billion in 2025 at a compound annual growth rate (CAGR) of 11.8%. The growth during the historic period can be attributed to the increasing demand for personalized medicine and biologics, advancements in structural proteomics, the expansion of academic research programs, and the growing need for biologics development.

The protein crystallization market size is expected to see rapid growth in the next few years. It will grow to $2.8 billion in 2029 at a compound annual growth rate (CAGR) of 11.5%. The projected growth during the forecast period can be attributed to the rising demand for protein-based drug development, the increasing prevalence of chronic diseases, expanded research in protein-ligand interactions, a growing emphasis on high-throughput screening methods, and the increasing need for specialized software in crystallography. Key trends expected during this period include technological advancements, AI integration in crystallization, automation in laboratory workflows, the development of hybrid techniques, and next-generation X-ray technologies.

The increasing demand for biopharmaceuticals is expected to drive the growth of the protein crystallization market. Biopharmaceuticals are medical drugs derived from biological sources or developed using advanced techniques such as protein-based therapies, vaccines, and gene therapies to treat various diseases and conditions. Their growing demand is attributed to their ability to provide targeted treatments, improve patient outcomes, and address chronic and complex diseases with personalized solutions that are often more effective than traditional therapies. Protein crystallization plays a crucial role in biopharmaceuticals by enabling the precise determination of protein structures, which enhances the development of targeted therapies and ensures better efficacy and stability in biopharmaceutical products. For example, in June 2024, the Australian Bureau of Statistics reported that during the 2022-23 period, Australian government organizations invested $4.34 billion in research and development, marking an increase of $726 million from 2020-21, while private non-profit organizations allocated $1.59 billion, an increase of $196 million compared to the previous period. This growing investment in research and development further supports the expansion of the protein crystallization market.

Companies in the protein crystallization market are focusing on innovative techniques to improve efficiency and resolution in protein crystallization, incorporating advanced methods such as cell-free protein crystallization. This approach allows for the study of unstable proteins, benefiting structural biology and drug discovery. Cell-free protein crystallization is a technique that facilitates the formation of protein crystals without relying on living cells, making the crystallization and analysis process more efficient. For example, in October 2022, the Tokyo Institute of Technology, a Japan-based public university, developed a groundbreaking cell-free protein crystallization method that enables direct protein crystal formation. This technique significantly improves protein crystallization efficiency and resolution for structural biology research and drug discovery applications, offering a more effective way to analyze previously difficult-to-study unstable proteins. It is expected to advance the understanding of complex cellular processes and contribute to the development of new therapeutic strategies.

In April 2022, Sygnature Discovery, a UK-based provider of integrated drug discovery and non-clinical solutions, acquired Peak Proteins for an undisclosed sum. This acquisition aims to strengthen Sygnature Discovery’s drug discovery capabilities by incorporating Peak Proteins’ expertise in protein production, crystallography, and structural analysis, accelerating the development of integrated drug discovery programs. Peak Proteins, a UK-based contract research organization, specializes in protein production and structure determination, further enhancing Sygnature Discovery’s research capabilities.

Major players in the protein crystallization market are Thermo Fisher Scientific, Corning Incorporated, Charles River Laboratories, Mettler-Toledo International Inc., Douglas Instruments Limited, Bruker Corporation, Tecan Group, Greiner Bio-One International GmbH, Rigaku Corporation, Viva Biotech, Formulatrix Inc., Creative Biostructure, Calibre Scientific Inc., Creative Biolabs, Molecular Dimensions, Creative Proteomics, Jena Bioscience GmbH, Saromics Biostructures, Art Robbins Instruments, Mitegen.

North America was the largest region in the protein crystallization market in 2024. Asia-Pacificis expected to be the fastest-growing region in the forecast period. The regions covered in protein crystallization report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the protein crystallization market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Protein crystallization is the process of inducing proteins to form well-ordered, three-dimensional crystals under controlled conditions, typically by adjusting factors such as temperature, pH, and the presence of specific solvents or salts. This technique is essential in structural biology, allowing researchers to analyze the atomic structure of proteins, primarily through methods such as X-ray diffraction, which provide valuable insights into protein functions and interactions.

The main product categories in protein crystallization include instruments, consumables, software, and services. Instruments refer to specialized devices and equipment used in scientific research to facilitate measurement, analysis, and manipulation, particularly in protein structure determination. Key technologies in this field include X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, and others. Protein crystallization is widely utilized by various end-users, including pharmaceutical and biotechnology companies, as well as academic and research institutes.

The protein crystallization market research report is one of a series of new reports that provides protein crystallization market statistics, including protein crystallization industry global market size, regional shares, competitors with a protein crystallization market share, detailed protein crystallization market segments, market trends and opportunities, and any further data you may need to thrive in the protein crystallization industry. This protein crystallization market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The protein crystallization market consists of revenues earned by entities by providing services such as custom crystallization assay development, cryogenic storage of protein crystals, x-ray diffraction data collection, automated crystallization platforms, and microgravity crystallization services. The market value includes the value of related goods sold by the service provider or included within the service offering. The protein crystallization market includes sales of protein crystallization screening kits, crystallization optimization reagents, crystallization equipment, cryo-electron microscopy (cryo-EM) systems for protein analysis, and crystallization software licenses. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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