Nerve Growth Factor Market Report 2025

The nerve growth factor market size has grown strongly in recent years. It will grow from $1.11 billion in 2024 to $1.19 billion in 2025 at a compound annual growth rate (CAGR) of 7.1%. The growth in the historic period can be attributed to rising incidence of traumatic brain injuries, increasing prevalence of neurodegenerative diseases, increasing investment in research and development activities, increasing awareness about nerve regeneration therapies, and increasing incidence of peripheral neuropathy.

The nerve growth factor market size is expected to see strong growth in the next few years. It will grow to $1.59 billion in 2029 at a compound annual growth rate (CAGR) of 7.6%. The growth in the forecast period can be attributed to rise in demand for biopharmaceuticals, rise in prevalence of autoimmune neurological disorders, increasing focus on neuroinflammation research, increasing investment in AI-driven drug discovery, and increasing consumer demand for NGF-based therapies. Major trends in the forecast period include advancements in biotechnology, personalized medicine approaches, innovative drug delivery systems, regulatory approvals, and development of nerve growth factor (NGF) antibodies.

The forecast of 7.6% growth over the next five years reflects a modest reduction of 0.4% from the previous estimate for this market. This reduction is primarily due to the impact of tariffs between the US and other countries. Tariff barriers are expected to hamper U.S. neurology research by increasing the cost of neurotrophic factor therapies sourced from Switzerland and South Korea, potentially delaying clinical trials for peripheral neuropathy and raising neurodegenerative disease treatment costs. The effect will also be felt more widely due to reciprocal tariffs and the negative effect on the global economy and trade due to increased trade tensions and restrictions.

The rising prevalence of neurological disorders is expected to drive the growth of the nerve growth factor (NGF) market. Neurological disorders, which impact the brain, spinal cord, and nerves, are caused by structural, biochemical, or electrical abnormalities. The growing prevalence of these disorders is mainly attributed to aging populations and advancements in diagnostic technologies. These technological improvements enhance the detection and reporting of neurological disorders, leading to a higher documented incidence. NGF plays a vital role in the maintenance, survival, and regeneration of neurons, making it essential for addressing neurological conditions by promoting neural repair and potentially slowing disease progression. For example, in September 2024, the Australian Institute of Health and Welfare projected that dementia cases in Australia would increase from approximately 411,100 in 2023 to 849,300 by 2058. As a result, the increasing prevalence of neurological disorders is contributing to the expansion of the NGF market.

Companies in the NGF market are focused on developing advanced products, such as NGF monoclonal antibodies, to inhibit NGF and provide effective pain relief. These monoclonal antibodies are biological drugs designed to target and neutralize NGF, blocking its interaction with receptors to reduce pain and inflammation in nerves. This approach helps regulate pain signaling and supports nerve cell survival. For instance, in February 2022, Akeso, Inc., a China-based biopharmaceutical company, introduced AK115, a humanized IgG1 monoclonal antibody. This antibody received approval from China's National Medical Products Administration to begin clinical trials for pain treatment, including cancer-related pain. AK115 works by blocking NGF’s interaction with receptors, aiming to offer long-term, non-addictive pain relief, particularly for opioid-resistant cancer patients, thus enhancing their quality of life.

In June 2023, Dompé Farmaceutici, an Italy-based company known for developing the first recombinant human nerve growth factor, partnered with FarmaMondo Group to expand access to Oxervate (cenegermin). Through this partnership, FarmaMondo became the exclusive distributor of Oxervate in certain countries, making it more accessible for patients with neurotrophic keratitis outside the U.S., Canada, Italy, China, and Switzerland. FarmaMondo Group, a Switzerland-based pharmaceutical services provider, specializes in offering care services for rare diseases. This collaboration helps broaden access to NGF treatments for those in need.

Major players in the nerve growth factor market are Pfizer Inc., AstraZeneca Plc, Eli Lilly & Company, Teva Pharmaceutical Industries, Regeneron Pharmaceuticals Inc., Genetech, Dompé farmaceutici S.p.A., Promega Corporation, Akeso Inc, CUSABIO TECHNOLOGY LLC, Staidson Beijing BioPharmaceuticals, Biocare Medical LLC, Beike Biotechnology, Enzo Life Sciences Inc., Genexis Biotech Pvt. Ltd., Mimetogen Pharmaceuticals, Alomone Labs, MimeTech Srl, Herantis Pharma, Prospec-Tany Technogene Ltd., PainCeptor Pharma.

Asia-Pacific was the largest region in the nerve growth factor market in 2024. The regions covered in nerve growth factor report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the nerve growth factor market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The nerve growth factor market consists of sales of nerve growth factor protein supplements, nerve growth factor enriched cell culture media, nerve growth factor biomarker detection kits, and diagnostic assays. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sudden escalation of U.S. tariffs and the resulting trade tensions in spring 2025 are having a significant impact on the pharmaceutical sector. Companies are grappling with higher costs on imported active pharmaceutical ingredients (APIs), glass vials, and laboratory equipment - many of which have limited alternative sources. Generic drug manufacturers, already operating with minimal profit margins, are particularly affected, with some scaling back production of low-margin medications. Biotech firms are also experiencing delays in clinical trials due to shortages of specialized reagents linked to tariffs. In response, the industry is shifting API production to regions like India and Europe, building up inventory reserves, and advocating for tariff exemptions on essential medicines.

The nerve growth factor market research report is one of a series of new reports that provides nerve growth factor market statistics, including the nerve growth factor industry global market size, regional shares, competitors with the nerve growth factor market share, detailed nerve growth factor market segments, market trends, and opportunities, and any further data you may need to thrive in the nerve growth factor industry. This nerve growth factor market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

Nerve growth factor (NGF) is a protein crucial for the growth, maintenance, and survival of nerve cells, particularly sensory and sympathetic neurons. It plays an essential role in the development of the nervous system and supports the regeneration of nerve cells following injury. NGF binds to specific receptors on nerve cells, activating pathways that aid in cell survival and differentiation.

The main types of nerve growth factors include alpha-nerve growth factor (NGF), beta-nerve growth factor (NGF), gamma-nerve growth factor (NGF), and others. Alpha-NGF is a protein vital for the growth and survival of neurons, as well as the development of the peripheral nervous system. It encompasses various agents, such as cenegermin, used for conditions such as neurodegenerative disorders, spinal cord injuries, eye disorders, epithelial diseases, tissue healing, and more. These treatments are distributed through multiple channels, including hospital pharmacies, online pharmacies, and retail pharmacies, and are utilized by a range of end users, including hospitals, home care settings, specialty clinics, and others.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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