Transient ischemic attack, also known as a mini stroke, is characterized by a temporary blockage of blood flow to the brain. It can cause stroke-like symptoms, lasting for a few minutes to a few hours. Various studies indicate the annual incidence of transient ischemic attack to be about 0.42 to 1.22 per 1000 person-years, with the incidence increasing with age. The growing cases of transient ischemic attacks are highlighting the need for new drugs that can address the underlying causes and reduce the risk of progression.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to transient ischemic attack.
Treatment for a transient ischemic attack consists of medication like statins and blood thinners that can help prevent a further episode. Popular anticoagulants include edoxaban, apixaban, dabigatran, warfarin, and rivaroxaban. However, the risk of bleeding remains a significant side effect for all anticoagulants. Thus, the limited availability of targeted and effective treatments with a better safety profile reflects a gap in patient care, which can be bridged through the development of more specialized drugs in the pipeline.
Sponsored by Bayer, the objective of this Phase III, multicenter, placebo-controlled clinical trial is to evaluate the efficacy of oral FXIa inhibitor, asundexian, for the prevention of ischemic stroke in male and female participants (aged 18 years and above) following a high-risk transient ischemic attack or acute non-cardioembolic ischemic stroke. The study is expected to be completed by October 2025 and has around 12300 participants.
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Report Coverage
The Transient Ischemic Attack Drug Pipeline Insight Report by the publisher gives comprehensive insights into transient ischemic attack drugs currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for transient ischemic attack. The report includes the analysis of over 100 pipeline drugs and 50+ companies. The transient ischemic attack pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials including their adverse effects on patients suffering from transient ischemic attack.The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to transient ischemic attack.
Transient Ischemic Attack Drug Pipeline Outlook
Transient ischemic attack causes a temporary disruption in the blood supply to a part of the brain. The transient episode of neurological dysfunction can resolve within minutes to hours. Transient ischemic attack needs prompt treatment as it indicates a warning sign of a possible future stroke. Common symptoms include a dropped face, weakness or numbness in one arm, slurred speech, and dizziness, among others.Treatment for a transient ischemic attack consists of medication like statins and blood thinners that can help prevent a further episode. Popular anticoagulants include edoxaban, apixaban, dabigatran, warfarin, and rivaroxaban. However, the risk of bleeding remains a significant side effect for all anticoagulants. Thus, the limited availability of targeted and effective treatments with a better safety profile reflects a gap in patient care, which can be bridged through the development of more specialized drugs in the pipeline.
Transient Ischemic Attack - Drug Pipeline Therapeutic Assessment
This section of the report covers the analysis of transient ischemic attack drugs based on several segmentations including:By Phase
- Late-Stage Products (Phase 3 and Phase 4)
- Mid-Stage Products (Phase 2)
- Early-Stage Products (Phase I)
- Preclinical and Discovery Stage Products
By Drug Class
- Small Molecules
- Peptides
- Oligonucleotides
- Biologics
By Route of Administration
- Oral
- Parenteral
- Others
Transient Ischemic Attack - Pipeline Assessment Segmentation, By Phases
The report covers phase I, phase II, phase III, phase IV, and early phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to analysis, phase III covers a major share of the total clinical trials for transient ischemic attacks.Transient Ischemic Attack - Pipeline Assessment Segmentation, By Drug Classes
The drug molecule categories covered under the transient ischemic attack pipeline analysis include small molecules, peptides, oligonucleotides, and biologics. The report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for transient ischemic attacks.Transient Ischemic Attack Clinical Trials Therapeutic Assessment - Competitive Dynamics
The report for the transient ischemic attack drug pipeline covers the profile of key companies involved in clinical trials and their drugs under development. Below is the list of a few players involved in transient ischemic attack clinical trials:- Janssen Research & Development, LLC
- Bayer
- Ischemia Care LLC
- Bristol Myers Squibb Company (BMS)
- Novo Nordisk A/S
Transient Ischemic Attack - Emerging Drugs Profile
Major drugs currently in the drug pipeline are as follows:
Drug: Asundexian (BAY2433334
)Sponsored by Bayer, the objective of this Phase III, multicenter, placebo-controlled clinical trial is to evaluate the efficacy of oral FXIa inhibitor, asundexian, for the prevention of ischemic stroke in male and female participants (aged 18 years and above) following a high-risk transient ischemic attack or acute non-cardioembolic ischemic stroke. The study is expected to be completed by October 2025 and has around 12300 participants.
Drug: Milvexian
Janssen Research & Development, LLC is conducting a Phase III clinical trial aimed at investigating the safety and efficacy of milvexian (an oral factor XIa inhibitor) compared to placebo for stroke prevention after a high-risk transient ischemic attack or an acute ischemic stroke. The interventional study has enrolled an estimated 15000 subjects and is expected to be completed by December 2026.Reasons To Buy This Report
The Transient Ischemic Attack Drug Pipeline Insight Report provides a strategic overview of the latest and future landscape of treatments for transient ischemic attack. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into market trends, regulatory environments, and potential growth opportunities within transient ischemic attack pipeline insights.Key Questions Answered in the Transient Ischemic Attack - Pipeline Insight Report
- What is the current landscape of transient ischemic attack pipeline drugs?
- How many companies are developing transient ischemic attack drugs?
- How many phase III and phase IV drugs are currently present in transient ischemic attack pipeline drugs?
- Which companies/institutions are leading the transient ischemic attack drug development?
- What is the efficacy and safety profile of transient ischemic attack pipeline drugs?
- What are the opportunities and challenges present in the transient ischemic attack drug pipeline landscape?
- Which company is conducting major trials for transient ischemic attack drugs?
- What geographies are covered for transient ischemic attack clinical trials?
- What are emerging trends in transient ischemic attack clinical trials?
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Table of Contents
1 Preface
3 Overview of Transient Ischemic Attack
4 Patient Profile: Transient Ischemic Attack
5 Transient Ischemic Attack: Epidemiology Snapshot
6 Transient Ischemic Attack: Market Dynamics
7 Transient Ischemic Attack: Key Facts Covered
8 Transient Ischemic Attack, Drug Pipeline Assessment
9 Drug Pipeline Comparative Analysis
10 Transient Ischemic Attack Drug Pipeline - Late-Stage Products (Phase III and IV) (Top Drugs)
11 Transient Ischemic Attack Drug Pipeline - Mid-Stage Products (Phase II) (Top Drugs)
12 Transient Ischemic Attack Drug Pipeline - Early-Stage Products (Phase I) (Top Drugs)
13 Transient Ischemic Attack Drug Pipeline - Preclinical and Discovery Stage Products (Top Drugs)
14 Transient Ischemic Attack, Key Drug Pipeline Companies