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Recurrent or Metastatic Head and Neck Cancer Pipeline Analysis Report 2025

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    Report

  • 200 Pages
  • June 2025
  • Region: Global
  • Expert Market Research
  • ID: 6102701
According to the Global Cancer Statistics of 2020, head and neck cancer ranked as the third most prevalent cancer globally. Head and neck cancer accounts for approximately 71,100 cases and 16,100 deaths annually in the United States. Head and neck cancer refers to several types of cancers which affect the mouth, throat, and other parts of the head and neck. Common symptoms include persistent sore throat. Companies are innovating more effective and tolerable targeted therapies to improve the outcomes for patients with head and neck cancer. Recent clinical trials have focused on identifying promising biomarkers and developing more effective targeted therapies.

Report Coverage

The Recurrent or Metastatic Head and Neck Cancer Drug Pipeline Report by the publisher gives comprehensive insights into recurrent or metastatic head and neck cancer drugs currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for recurrent or metastatic head and neck cancer. The report includes the analysis of over 100 pipeline drugs and 50+ companies. It will include an analysis based on efficacy and safety measure outcomes published for the trials including their adverse effects on patients suffering from recurrent or metastatic head and neck cancer.

The detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration and ongoing product development activities related to recurrent or metastatic head and neck cancer are covered.

Recurrent or Metastatic Head and Neck Cancer Drug Pipeline Outlook

Head and neck cancer includes various types of cancer which usually start in the cells lining mouth, throat, or larynx. These cells are called squamous cells. Though less common, head and neck cancers form in sinuses or salivary glands as well. Most of the head and neck cancers are classified as squamous cell carcinoma after the cell which changes into cancer cell. Head and neck cancers include oral cancer, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer, nasopharyngeal cancer, and salivary gland cancer among others. Head and neck cancer is difficult to diagnose because symptoms are mild and can mimic less serious conditions like a cold or sore throat. The symptoms include persistent sore throat, pain in upper teeth, frequent headaches, voice changes and facial numbness or pain among others.

The treatment for head and neck cancer varies depending on the stage and type of cancer. It mainly involves surgery, radiation therapy and chemotherapy, targeted therapy, and immunotherapy. Targeted therapy is mostly given in combination with other treatments to treat advanced head and neck cancers. Cetuximab (Erbitux®) is a drug which targets a tumor protein called epidermal growth factor and is approved by the U.S. FDA to treat head and neck cancers. Currently clinical trials on head and neck cancer treatments are evaluating new immunotherapy drugs and radiation therapy techniques. Clinical trials are also focused on identifying promising biomarkers and developing more effective targeted therapies.

Recurrent or Metastatic Head and Neck Cancer - Drug Pipeline Therapeutic Assessment

This section of the report covers the analysis of recurrent or metastatic head and neck cancer drugs based on several segmentations including:

By Phase

The pipeline assessment report covers 50+ drug analyses based on phase.
  • Late-Stage Products (Phase 3 and Phase 4)
  • Mid-Stage Products (Phase 2)
  • Early-Stage Products (Phase I)
  • Preclinical and Discovery Stage Products

By Drug Class

The pipeline assessment report covers 50+ drug analyses based on drug classes:

  • Small Molecule
  • Cell Therapy
  • Peptides
  • Polymer
  • Gene Therapy

By Route of Administration

The pipeline assessment report covers 50+ drug analyses based on the route of administration.
  • Oral
  • Parenteral
  • Others

Recurrent or Metastatic Head and Neck Cancer - Pipeline Assessment Segmentation, By Phases

The report covers phase I, phase II, phase III, phase IV, and early phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to analysis, phase II covers a major share of the total clinical trials for recurrent or metastatic head and neck cancer with 410 pipeline drugs in the respective phase.

Recurrent or Metastatic Head and Neck Cancer - Pipeline Assessment Segmentation, By Drug Classes

The drug molecules categories covered under recurrent or metastatic head and neck cancer pipeline analysis include cell therapy, peptides, polymer, small molecule, and gene therapy. Immune therapies are the most recent advancements in the field of head and neck cancer. It boosts the patient’s immune system to fight the spreading of tumors. The report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for recurrent or metastatic head and neck cancer.

Recurrent or Metastatic Head and Neck Cancer Clinical Trials Assessment - Competitive Dynamics

The report for the recurrent or metastatic head and neck cancer drug pipeline covers the profile of key companies involved in clinical trials and their drugs under development. Below is the list of a few players involved in recurrent or metastatic head and neck cancer clinical trials:
  • Sanofi
  • Bristol-Myers Squibb
  • Eli Lilly and Company
  • Pierre Fabre Medicament
  • Trisha Wise-Draper
  • Pfizer
  • Nektar Therapeutics
  • Coordination Pharmaceuticals, Inc.
  • Amgen
  • Dynavax Technologies Corporation
  • Merck Sharp & Dohme LLC
  • Innate Pharma
  • Ikena Oncology
  • Others

Recurrent or Metastatic Head and Neck Cancer - Pipeline Drugs Profile

Drug: Pemetrexed

The trial is designed to investigate the improvement in progression-free survival with the combination of pemetrexed, carboplatin and cetuximab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. The trial is sponsored by Eli Lilly and Company and is currently under phase II.

Drug: PF-00299804

Pfizer is developing the drug and is currently under phase II. The study is being designed to evaluate the safety and efficacy of oral PF-00299804 in patients with recurrent and/ or metastatic head and neck squamous cell cancer.

Reasons To Buy This Report

The Recurrent or Metastatic Head and Neck Cancer Drug Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for recurrent or metastatic head and neck cancer. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into market trends, regulatory environments, and potential growth opportunities within recurrent or metastatic head and neck cancer pipeline insights.

Key Questions Answered in the Recurrent or Metastatic Head and Neck Cancer - Pipeline Assessment Report

  • What is the current landscape of recurrent or metastatic head and neck cancer pipeline drugs?
  • How many companies are developing recurrent or metastatic head and neck cancer drugs?
  • How many phase III and phase IV drugs are currently present in recurrent or metastatic head and neck cancer pipeline drugs?
  • Which companies/institutions are leading the recurrent or metastatic head and neck cancer drug development?
  • What is the efficacy and safety profile of recurrent or metastatic head and neck cancer pipeline drugs?
  • What are the opportunities and challenges present in the recurrent or metastatic head and neck cancer drug pipeline landscape?
  • Which company is conducting major trials for recurrent or metastatic head and neck cancer drugs?
  • What are the geographies covered for clinical trials in recurrent or metastatic head and neck cancer?
  • What are emerging trends in recurrent or metastatic head and neck cancer clinical trials?

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Table of Contents

1 Preface
1.1 Introduction
1.2 Objectives of the Study
1.3 Research Methodology and Assumptions
2 Executive Summary
3 Overview of Recurrent or Metastatic Head and Neck Cancer
3.1 Signs and Symptoms
3.2 Causes
3.3 Risk Factors
3.4 Diagnosis
3.5 Treatment
4 Patient Profile: Recurrent or Metastatic Head and Neck Cancer
4.1 Patient Profile Overview
4.2 Patient Psychology and Emotional Impact Factors
4.3 Risk Assessment and Treatment Success Rate
5 Recurrent or Metastatic Head and Neck Cancer: Epidemiology Snapshot
5.1 Recurrent or Metastatic Head and Neck Cancer Incidence by Key Markets
5.2 Recurrent or Metastatic Head and Neck Cancer - Patients Seeking Treatment in Key Markets
6 Recurrent or Metastatic Head and Neck Cancer: Market Dynamics
6.1 Market Drivers and Constraints
6.2 SWOT Analysis
7 Recurrent or Metastatic Head and Neck Cancer: Key Facts Covered
7.1 Top Countries Contributing to Clinical Trials in Asia-Pacific
7.2 Top Countries Contributing to Clinical Trials in Europe
7.3 Top Countries Contributing to Clinical Trials in North America
7.4 Top Countries Contributing to Clinical Trials in Other Regions
8 Recurrent or Metastatic Head and Neck Cancer, Drug Pipeline Assessment
8.1 Assessment by Treatment Type
8.2 Assessment by Route of Administration
8.3 Assessment by Drug Class
9 Drug Pipeline Comparative Analysis
9.1 List of Recurrent or Metastatic Head and Neck Cancer Pipeline Drugs
9.1.1 By Company
9.1.2 By Phase
9.1.3 By Indication
9.1.4 By Trial Status
9.1.5 By Funder Type
9.2 Attribute Scoring Analysis of Pipeline Drugs (Top Drugs)
10 Recurrent or Metastatic Head and Neck Cancer Drug Pipeline - Late-Stage Products (Phase III and IV) (Top Drugs)
10.1 Comparative Analysis for Late-Stage Drugs
10.1.1 Study Type
10.1.2 Recruitment Status
10.1.3 Company
10.1.4 Funder Type
10.2 Product Level Analysis*
10.2.1 Vinflunine
10.2.1.1 Product Description
10.2.1.2 Trial ID
10.2.1.3 Sponsor Name
10.2.1.4 Study Type
10.2.1.5 Drug Class
10.2.1.6 Eligibility Criteria
10.2.1.7 Study Record Dates
10.2.1.7.1 First Submitted
10.2.1.7.2 First Posted
10.2.1.7.3 Last Update Posted
10.2.1.7.4 Last Verified
10.2.1.8 Indication
10.2.1.9 Study Design
10.2.1.10 Recruitment Status
10.2.1.11 Enrollment (Estimated)
10.2.1.12 Location Countries
10.2.1.13 Recent Results
10.2.2 Pembrolizumab
10.2.3 Buparlisib & Paclitaxel
10.2.4 Other Drugs
11 Recurrent or Metastatic Head and Neck Cancer Drug Pipeline - Mid-Stage Products (Phase II) (Top Drugs)
11.1 Comparative Analysis for Mid-Stage Drugs
11.1.1 Study Type
11.1.2 Recruitment Status
11.1.3 Company
11.1.4 Funder Type
11.2 Product Level Analysis*
11.2.1 Cisplatin
11.2.1.1 Product Description
11.2.1.2 Trial ID
11.2.1.3 Sponsor Name
11.2.1.4 Study Type
11.2.1.5 Drug Class
11.2.1.6 Eligibility Criteria
11.2.1.7 Study Record Dates
11.2.1.7.1 First Submitted
11.2.1.7.2 First Posted
11.2.1.7.3 Last Update Posted
11.2.1.7.4 Last Verified
11.2.1.8 Indication
11.2.1.9 Study Design
11.2.1.10 Recruitment Status
11.2.1.11 Enrollment (Estimated)
11.2.1.12 Location Countries
11.2.1.13 Recent Results
11.2.2 Pemetrexed
11.2.3 Other Drugs
12 Recurrent or Metastatic Head and Neck Cancer Drug Pipeline - Early-Stage Products (Phase I) (Top Drugs)
12.1 Comparative Analysis for Early-Stage Drugs
12.1.1 Study Type
12.1.2 Recruitment Status
12.1.3 Company
12.1.4 Funder Type
12.2 Product Level Analysis*
12.2.1 Monalizumab
12.2.1.1 Product Description
12.2.1.2 Trial ID
12.2.1.3 Sponsor Name
12.2.1.4 Study Type
12.2.1.5 Drug Class
12.2.1.6 Eligibility Criteria
12.2.1.7 Study Record Dates
12.2.1.7.1 First Submitted
12.2.1.7.2 First Posted
12.2.1.7.3 Last Update Posted
12.2.1.7.4 Last Verified
12.2.1.8 Indication
12.2.1.9 Study Design
12.2.1.10 Recruitment Status
12.2.1.11 Enrollment (Estimated)
12.2.1.12 Location Countries
12.2.2 Gemcitabine
12.2.3 Other Drugs
13 Recurrent or Metastatic Head and Neck Cancer Drug Pipeline - Preclinical and Discovery Stage Products (Top Drugs)
13.1 Comparative Analysis for Preclinical and Discovery Stage Drugs
13.1.1 Study Type
13.1.2 Recruitment Status
13.1.3 Company
13.1.4 Funder Type
13.2 Product Level Analysis*
13.2.1 Drug 1
13.2.1.1 Product Description
13.2.1.2 Trial ID
13.2.1.3 Sponsor Name
13.2.1.4 Study Type
13.2.1.5 Drug Class
13.2.1.6 Eligibility Criteria
13.2.1.7 Study Record Dates
13.2.1.7.1 First Submitted
13.2.1.7.2 First Posted
13.2.1.7.3 Last Update Posted
13.2.1.7.4 Last Verified
13.2.1.8 Indication
13.2.1.9 Study Design
13.2.1.10 Recruitment Status
13.2.1.11 Enrollment (Estimated)
13.2.1.12 Location Countries
13.2.2 Other Drugs
14 Recurrent or Metastatic Head and Neck Cancer, Key Drug Pipeline Companies
14.1 Sanofi
14.1.1 Company Snapshot
14.1.2 Pipeline Product Portfolio
14.1.3 Financial Analysis
14.1.4 Recent News and Developments
14.2 Bristol-Myers Squibb
14.2.1 Company Snapshot
14.2.2 Pipeline Product Portfolio
14.2.3 Financial Analysis
14.2.4 Recent News and Developments
14.3 Eli Lilly and Company
14.3.1 Company Snapshot
14.3.2 Pipeline Product Portfolio
14.3.3 Financial Analysis
14.3.4 Recent News and Developments
14.4 Pierre Fabre Medicament
14.4.1 Company Snapshot
14.4.2 Pipeline Product Portfolio
14.4.3 Financial Analysis
14.4.4 Recent News and Developments
14.5 Trisha Wise-Draper
14.5.1 Company Snapshot
14.5.2 Pipeline Product Portfolio
14.5.3 Financial Analysis
14.5.4 Recent News and Developments
14.6 Pfizer
14.6.1 Company Snapshot
14.6.2 Pipeline Product Portfolio
14.6.3 Financial Analysis
14.6.4 Recent News and Developments
14.7 Nektar Therapeutics
14.7.1 Company Snapshot
14.7.2 Pipeline Product Portfolio
14.7.3 Financial Analysis
14.7.4 Recent News and Developments
14.8 Coordination Pharmaceuticals, Inc.
14.8.1 Company Snapshot
14.8.2 Pipeline Product Portfolio
14.8.3 Financial Analysis
14.8.4 Recent News and Developments
14.9 Amgen
14.9.1 Company Snapshot
14.9.2 Pipeline Product Portfolio
14.9.3 Financial Analysis
14.9.4 Recent News and Developments
14.10 Dynavax Technologies Corporation
14.10.1 Company Snapshot
14.10.2 Pipeline Product Portfolio
14.10.3 Financial Analysis
14.10.4 Recent News and Developments
14.11 Merck Sharp & Dohme LLC
14.11.1 Company Snapshot
14.11.2 Pipeline Product Portfolio
14.11.3 Financial Analysis
14.11.4 Recent News and Developments
14.12 Innate Pharma
14.12.1 Company Snapshot
14.12.2 Pipeline Product Portfolio
14.12.3 Financial Analysis
14.12.4 Recent News and Developments
14.13 Ikena Oncology
14.13.1 Company Snapshot
14.13.2 Pipeline Product Portfolio
14.13.3 Financial Analysis
14.13.4 Recent News and Developments
15 Regulatory Framework for Drug Approval, By Region16 Terminated or Suspended Pipeline Products