+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)
New

Post-Traumatic Stress Disorder (PTSD) Pipeline Analysis Report 2025

  • PDF Icon

    Report

  • 200 Pages
  • June 2025
  • Region: Global
  • Expert Market Research
  • ID: 6102710
According to the World Health Organization, 3.9% of the global population has had post-traumatic stress disorder (PTSD) at some stage in their lives. The PTSD incidence is approximately three times higher among people who are exposed to violent conflicts or war. Although the primary treatment is psychotherapy, the drug pipeline for PTSD treatment remains strong. Several companies are involved in research and development to conduct effective drugs, influencing the pipeline landscape significantly.

Report Coverage

The Post-Traumatic Stress Disorder (PTSD) Drug Pipeline Report by the publisher gives comprehensive insights into ongoing post-traumatic stress disorder (PTSD) clinical trials. It covers various aspects related to the details of each of these drugs under development for post-traumatic stress disorder (PTSD). The report includes the analysis of over 100 pipeline drugs and 50+ companies. The post-traumatic stress disorder (PTSD) pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials including their adverse effects on patients suffering from post-traumatic stress disorder (PTSD).

The detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration and ongoing post-traumatic stress disorder (PTSD) pipeline development activities are covered. Moreover, post-traumatic stress disorder (PTSD) collaborations and commercial assessments are offered, helping stakeholders to make informed decisions.

Post-Traumatic Stress Disorder (PTSD) Drug Pipeline Outlook

Post-traumatic stress disorder (PTSD) is a mental health condition that develops after a traumatic event. The symptoms of this disorder involve anxiety, flashbacks, negative thoughts and beliefs, and hypervigilance among others. People who go through traumatic events may have temporary difficulty in adjusting and coping. Moreover, if the symptoms get worse and interfere with day-to-day functioning, it can develop into PTSD. The symptoms of PTSD may start within one month of a traumatic event. It can interfere with the ability to do normal daily tasks. Generally, post-traumatic stress disorder (PTSD) symptoms are grouped into four types, including, intrusive memories, negative changes in thinking and mood, avoidance, and changes in physical and emotional reactions.

There are two types of post-traumatic stress disorder (PTSD) including acute stress disorder and complex PTSD (CPTSD). Acute stress disorder is a short-term mental health condition which can occur within the first month after experiencing a traumatic event. Complex PTSD is a mental health condition which can develop if a person experiences chronic trauma which includes long-term child physical or sexual abuse, long-term domestic violence and war among others.

The primary post-traumatic stress disorder (PTSD) treatment includes psychotherapy (talk therapy), especially forms of cognitive behavioral therapy (CBT). The specific forms of CBT include cognitive processing therapy, eye movement desensitization and reprocessing (EMDR) therapy, group therapy, prolonged exposure therapy and trauma-focused CBT. Currently, there are no medications approved by the Food and Drug Administration (FDA) for the treatment of post-traumatic stress disorder (PTSD). However, healthcare providers prescribe certain medications including antidepressants like selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs) and anti-anxiety medications.

Several pharma companies are developing innovative treatments to manage post-traumatic stress disorder (PTSD). There has been a significant growth in the treatment options for the condition. Positive results from clinical trials during the past decade of medication-assisted psychotherapy are providing hope to manage the disease effectively.

Post-Traumatic Stress Disorder (PTSD) Epidemiology

Around 3.9% of people worldwide are estimated to experience post-traumatic stress disorder (PTSD) at some point in their lives. However, this number rises sharply in individuals exposed to violent conflict or war, with rates reported to be as high as 15.3% - nearly three times higher than the global average. The risk is also significantly higher following experiences of sexual violence. In the general population, about 6 in every 100 adults are likely to develop PTSD during their lifetime, with women being twice as likely as men to be affected. Complex PTSD, a more severe form, is estimated to impact between 1% and 8% of people globally.

Post-Traumatic Stress Disorder (PTSD) - Drug Pipeline Therapeutic Assessment

This section of the report covers the analysis of post-traumatic stress disorder (PTSD) drug candidates based on several segmentations including:

By Phase

The pipeline assessment report covers 50+ drug analyses based on phase.
  • Late-Stage Products (Phase 3 and Phase 4)
  • Mid-Stage Products (Phase 2)
  • Early-Stage Products (Phase I)
  • Preclinical and Discovery Stage Products

By Drug Class

The post-traumatic stress disorder (PTSD) therapeutics assessment report covers 50+ drug analyses based on drug classes:

  • Recombinant Fusion Proteins
  • Small Molecule
  • Monoclonal Antibody
  • Peptide
  • Polymer
  • Gene Therapy

By Route of Administration

The pipeline assessment report covers 50+ drug analyses based on the route of administration.
  • Oral
  • Parenteral
  • Others

Post-Traumatic Stress Disorder (PTSD) - Pipeline Assessment Segmentation, By Phases

The report covers phase I, phase II, phase III, phase IV, and early phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to analysis, phase II covers a major share of the total clinical trials for post-traumatic stress disorder (PTSD).

The PTSD drug pipeline includes a total of 466 drugs at various stages of development. Phase 2 holds the largest share, making up about 40% of the pipeline, followed by Phase 1 at 21%. Phase 3 accounts for 18%, while Phase 4 represents around 16%. Early Phase 1 makes up the smallest portion, with just 5%. This distribution shows a strong emphasis on mid-stage clinical research for PTSD treatments.

Post-Traumatic Stress Disorder (PTSD) - Pipeline Assessment Segmentation, By Drug Classes

The drug molecules categories covered under post-traumatic stress disorder (PTSD) pipeline analysis include recombinant fusion proteins, small molecules, monoclonal antibodies, peptides, polymer, and gene therapy. Currently under phase II, Jazz Pharmaceuticals is developing an investigational small molecule drug called JZP150 to treat post-traumatic stress disorder (PTSD) in adults. The report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for post-traumatic stress disorder (PTSD).

Post-Traumatic Stress Disorder (PTSD) Clinical Trials Assessment - Competitive Dynamics

The post-traumatic stress disorder (PTSD) drug report insights involve the profile of key companies involved in clinical trials and their drugs under development. Below is the list of a few players involved in PTSD clinical trials:
  • Hoffmann-La Roche
  • Synchroneuron Inc.
  • Klarisana Physician Services PLLC
  • Otsuka Pharmaceutical Development & Commercialization, Inc.
  • Apollo Neuroscience, Inc.
  • Palo Alto Health Sciences, Inc.
  • Jazz Pharmaceuticals
  • HealthTech Connex Inc.
  • Boehringer Ingelheim
  • GlaxoSmithKline
  • Nobilis Therapeutics Inc.
  • Others

Post-Traumatic Stress Disorder (PTSD) Emerging Drugs Profile

This section covers the detailed analysis of each drug under multiple phases including phase I, phase II, phase III, phase IV, and emerging drugs for post-traumatic stress disorder (PTSD). It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of post-traumatic stress disorder (PTSD) drug candidates.

Drug: Balovaptan

The trial is designed to evaluate the safety and effectiveness of administering 10 mg of balovaptan orally once a day in comparison to a similar placebo in adults with post-traumatic stress disorder (PTSD). The trial is sponsored by Hoffmann-La Roche and is currently under phase II.

Drug: JZP150

The objective of the study is to assess the clinical safety and effectiveness of ZP150 in the treatment of adults with post-traumatic stress disorder (PTSD). The trial is sponsored by Jazz Pharmaceuticals and is currently under phase II.

Drug: BI 1358894

Boehringer Ingelheim is developing this drug and is currently under phase II. The study is being conducted to find out whether the drug improves symptoms in post-traumatic stress disorder (PTSD) affected patients.

Reasons To Buy This Report

The Post-Traumatic Stress Disorder (PTSD) Drug Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for post-traumatic stress disorder (PTSD). It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into post-traumatic stress disorder (PTSD) collaborations, regulatory environments, and potential growth opportunities within the treatment landscape.

Key Questions Answered in the Post-Traumatic Stress Disorder (PTSD) - Pipeline Assessment Report

  • Which companies/institutions are leading the post-traumatic stress disorder (PTSD) drug development?
  • What is the efficacy and safety profile of post-traumatic stress disorder (PTSD) pipeline drugs?
  • Which company is leading the post-traumatic stress disorder (PTSD) pipeline development activities?
  • What is the current post-traumatic stress disorder (PTSD) commercial assessment?
  • What are the opportunities and challenges present in the post-traumatic stress disorder (PTSD) drug pipeline landscape?
  • What is the efficacy and safety profile of post-traumatic stress disorder (PTSD) pipeline drugs?
  • Which company is conducting major trials for post-traumatic stress disorder (PTSD) drugs?
  • Which companies/institutions are involved in post-traumatic stress disorder (PTSD) collaborations aimed at providing enhanced therapeutic alternatives for patients?
  • What are the geographies covered for clinical trials in post-traumatic stress disorder (PTSD)?

This product will be delivered within 3-5 business days.

Table of Contents

1 Preface
1.1 Introduction
1.2 Objectives of the Study
1.3 Research Methodology and Assumptions
2 Executive Summary
3 Overview of Post-Traumatic Stress Disorder (PTSD)
3.1 Signs and Symptoms
3.2 Causes
3.3 Risk Factors
3.4 Types of Post-Traumatic Stress Disorder (PTSD)
3.5 Diagnosis
3.6 Treatment
4 Patient Profile: Post-Traumatic Stress Disorder (PTSD)
4.1 Patient Profile Overview
4.2 Patient Psychology and Emotional Impact Factors
4.3 Risk Assessment and Treatment Success Rate
5 Post-Traumatic Stress Disorder (PTSD): Epidemiology Snapshot
5.1 Post-Traumatic Stress Disorder (PTSD) Incidence by Key Markets
5.2 Post-Traumatic Stress Disorder (PTSD) - Patients Seeking Treatment in Key Markets
6 Post-Traumatic Stress Disorder (PTSD): Market Dynamics
6.1 Market Drivers and Constraints
6.2 SWOT Analysis
7 Post-Traumatic Stress Disorder (PTSD): Key Facts Covered
7.1 Top Countries Contributing to Clinical Trials in Asia-Pacific
7.2 Top Countries Contributing to Clinical Trials in Europe
7.3 Top Countries Contributing to Clinical Trials in North America
7.4 Top Countries Contributing to Clinical Trials in Other Regions
8 Post-Traumatic Stress Disorder (PTSD), Drug Pipeline Assessment
8.1 Assessment by Treatment Type
8.2 Assessment by Route of Administration
8.3 Assessment by Drug Class
9 Drug Pipeline Comparative Analysis
9.1 List of Post-Traumatic Stress Disorder (PTSD) Pipeline Drugs
9.1.1 By Company
9.1.2 By Phase
9.1.3 By Indication
9.1.4 By Trial Status
9.1.5 By Funder Type
9.2 Attribute Scoring Analysis of Pipeline Drugs (Top Drugs)
10 Post-Traumatic Stress Disorder (PTSD) Drug Pipeline - Late-Stage Products (Phase III and IV) (Top Drugs)
10.1 Comparative Analysis for Late-Stage Drugs
10.1.1 Study Type
10.1.2 Recruitment Status
10.1.3 Company
10.1.4 Funder Type
10.2 Product Level Analysis*
10.2.1 Brexpiprazole
10.2.1.1 Product Description
10.2.1.2 Trial ID
10.2.1.3 Sponsor Name
10.2.1.4 Study Type
10.2.1.5 Drug Class
10.2.1.6 Eligibility Criteria
10.2.1.7 Study Record Dates
10.2.1.7.1 First Submitted
10.2.1.7.2 First Posted
10.2.1.7.3 Last Update Posted
10.2.1.7.4 Last Verified
10.2.1.8 Indication
10.2.1.9 Study Design
10.2.1.10 Recruitment Status
10.2.1.11 Enrollment (Estimated)
10.2.1.12 Location Countries
10.2.1.13 Recent Results
10.2.2 Nabiximols
10.2.3 Sertraline
10.2.4 Other Drugs
11 Post-Traumatic Stress Disorder (PTSD) Drug Pipeline - Mid-Stage Products (Phase II) (Top Drugs)
11.1 Comparative Analysis for Mid-Stage Drugs
11.1.1 Study Type
11.1.2 Recruitment Status
11.1.3 Company
11.1.4 Funder Type
11.2 Product Level Analysis*
11.2.1 Balovaptan
11.2.1.1 Product Description
11.2.1.2 Trial ID
11.2.1.3 Sponsor Name
11.2.1.4 Study Type
11.2.1.5 Drug Class
11.2.1.6 Eligibility Criteria
11.2.1.7 Study Record Dates
11.2.1.7.1 First Submitted
11.2.1.7.2 First Posted
11.2.1.7.3 Last Update Posted
11.2.1.7.4 Last Verified
11.2.1.8 Indication
11.2.1.9 Study Design
11.2.1.10 Recruitment Status
11.2.1.11 Enrollment (Estimated)
11.2.1.12 Location Countries
11.2.1.13 Recent Results
11.2.2 Risperidone
11.2.3 Other Drugs
12 Post-Traumatic Stress Disorder (PTSD) Drug Pipeline - Early-Stage Products (Phase I) (Top Drugs)
12.1 Comparative Analysis for Early-Stage Drugs
12.1.1 Study Type
12.1.2 Recruitment Status
12.1.3 Company
12.1.4 Funder Type
12.2 Product Level Analysis*
12.2.1 Methylone
12.2.1.1 Product Description
12.2.1.2 Trial ID
12.2.1.3 Sponsor Name
12.2.1.4 Study Type
12.2.1.5 Drug Class
12.2.1.6 Eligibility Criteria
12.2.1.7 Study Record Dates
12.2.1.7.1 First Submitted
12.2.1.7.2 First Posted
12.2.1.7.3 Last Update Posted
12.2.1.7.4 Last Verified
12.2.1.8 Indication
12.2.1.9 Study Design
12.2.1.10 Recruitment Status
12.2.1.11 Enrollment (Estimated)
12.2.1.12 Location Countries
12.2.2 Propranolol
12.2.3 Other Drugs
13 Post-Traumatic Stress Disorder (PTSD) Drug Pipeline - Preclinical and Discovery Stage Products (Top Drugs)
13.1 Comparative Analysis for Preclinical and Discovery Stage Drugs
13.1.1 Study Type
13.1.2 Recruitment Status
13.1.3 Company
13.1.4 Funder Type
13.2 Product Level Analysis*
13.2.1 Drug 1
13.2.1.1 Product Description
13.2.1.2 Trial ID
13.2.1.3 Sponsor Name
13.2.1.4 Study Type
13.2.1.5 Drug Class
13.2.1.6 Eligibility Criteria
13.2.1.7 Study Record Dates
13.2.1.7.1 First Submitted
13.2.1.7.2 First Posted
13.2.1.7.3 Last Update Posted
13.2.1.7.4 Last Verified
13.2.1.8 Indication
13.2.1.9 Study Design
13.2.1.10 Recruitment Status
13.2.1.11 Enrollment (Estimated)
13.2.1.12 Location Countries
13.2.2 Other Drugs
14 Post-Traumatic Stress Disorder (PTSD), Key Drug Pipeline Companies
14.1 Hoffmann-La Roche
14.1.1 Company Snapshot
14.1.2 Pipeline Product Portfolio
14.1.3 Financial Analysis
14.1.4 Recent News and Developments
14.2 Synchroneuron Inc.
14.2.1 Company Snapshot
14.2.2 Pipeline Product Portfolio
14.2.3 Financial Analysis
14.2.4 Recent News and Developments
14.3 Klarisana Physician Services PLLC
14.3.1 Company Snapshot
14.3.2 Pipeline Product Portfolio
14.3.3 Financial Analysis
14.3.4 Recent News and Developments
14.4 Otsuka Pharmaceutical Development & Commercialization, Inc.
14.4.1 Company Snapshot
14.4.2 Pipeline Product Portfolio
14.4.3 Financial Analysis
14.4.4 Recent News and Developments
14.5 Apollo Neuroscience, Inc.
14.5.1 Company Snapshot
14.5.2 Pipeline Product Portfolio
14.5.3 Financial Analysis
14.5.4 Recent News and Developments
14.6 Palo Alto Health Sciences, Inc.
14.6.1 Company Snapshot
14.6.2 Pipeline Product Portfolio
14.6.3 Financial Analysis
14.6.4 Recent News and Developments
14.7 Jazz Pharmaceuticals
14.7.1 Company Snapshot
14.7.2 Pipeline Product Portfolio
14.7.3 Financial Analysis
14.7.4 Recent News and Developments
14.8 HealthTech Connex Inc.
14.8.1 Company Snapshot
14.8.2 Pipeline Product Portfolio
14.8.3 Financial Analysis
14.8.4 Recent News and Developments
14.9 Boehringer Ingelheim
14.9.1 Company Snapshot
14.9.2 Pipeline Product Portfolio
14.9.3 Financial Analysis
14.9.4 Recent News and Developments
14.10 GlaxoSmithKline
14.10.1 Company Snapshot
14.10.2 Pipeline Product Portfolio
14.10.3 Financial Analysis
14.10.4 Recent News and Developments
14.11 Nobilis Therapeutics Inc.
14.11.1 Company Snapshot
14.11.2 Pipeline Product Portfolio
14.11.3 Financial Analysis
14.11.4 Recent News and Developments
15 Regulatory Framework for Drug Approval, By Region16 Terminated or Suspended Pipeline Products