Promising Cancer Therapeutic Drug Targets: Recent Advancements offers a comprehensive overview of novel and emerging strategies in cancer therapy. The book explores cutting-edge approaches such as exosomal delivery systems, CRISPR/Cas9 gene editing, and immunotoxins, alongside targeting mechanisms like cancer stem cells, apoptosis pathways, and key signaling processes.
A strong emphasis is placed on the therapeutic potential of natural compounds in disrupting cancer progression and enhancing treatment response. Chapters are organized around molecular targets, therapeutic pathways, and bioactive agents to provide a clear, thematic structure.
Key Features
- In-depth exploration of CRISPR/Cas9, exosomes, and stem cell-targeted therapy
- Focus on natural compounds in cancer treatment
- Insights into key signaling pathways (Hippo, Hedgehog, STAT3)
- Discussion on apoptosis and drug resistance mechanisms.
Table of Contents
Chapter 1 Exosomal Delivery of CRISPR/CAS9 Assembly: Approach Towards Cancer Therapeutics
- Introduction
- CRISPR as a Potential Therapeutic Agent for Metastasis
- Molecules Involved in Metastasis
- Metastatic Molecules Targeted by CRISPR/Cas9 System
- Exosomes as a Potential Carrier (Therapeutic Carrier): Exosome-based
- Delivery of Small Molecules, Bioactive Molecules, Sirna
- Great Beginning of the CRISPR/Cas System in Human Trials
- Different Delivery Systems for CRISPR/Cas
- Exosomal-Based Delivery for CRISPR
- Conclusion
- Future Perspective
- References
Chapter 2 Cancer Stem Cells and Their Role in Chemo-Resistance
- Introduction
- Normal Stem Cells and Cancer Stem Cells Linked to Carcinogenesis
- Transporter Proteins in Stem Cells and Cancer
- Chemotherapy Resistance in Cancer and Cancer Stem Cells
- Controlling Drug-Resistant Cancer Cells
- Cell Signaling in Cancer Stem Cells Cancer Therapy
- Conclusion
- References
Chapter 3 Importance of Natural Compounds Targeting The Mitophagic Process in Breast Cancer Treatment
- Introduction
- Breast Cancer Statistics
- Breast Cancer and the Indian Scenario
- Mitophagy
- Mitophagy and Cancer
- Mutations in Park2 (Parkin)
- Mitophagy Mediated by Hif1Α - Bnip3, Nix, and Fundc1
- Hif1Α and the Tumor Microenvironment
- Bnip3 and Nix in Cancer Mitophagy
- Fundc1 in Cancer Mitophagy
- Kras Mutations and Cancer Mitophagy
- Biological Role of Mitophagy
- Manipulating Mitophagy as a Potential Target for Cancer Therapy
- Induction of Mitophagy Increases Cancer Cell Death and Chemotherapy Sensitivity
- Inhibition of Mitophagy Enhances Drug Sensitivity
- Classical Inhibitors of Mitophagy
- Novel Inhibitors of Mitophagy
- Role of Natural Compounds in Mitophagy
- Withaferin
- Curcumin
- Gingerol
- Thymoquinone
- Artepillin C
- Cucurbitacin B
- Triptolide
- Allicin
- Jolkinolide B
- Chalocomoracin
- Conclusion
- Author's Contribution
- References
Chapter 4 Bioactive Natural Compounds as Inhibitors of Signal Transducer and Activator of Transcription 3: Prospects in Anticancer Therapeutics
- Introduction
- Therapeutic Targeting of Stat3 Signaling in Cancer
- Targeting of Stat3 to Prevent Activation
- Targeting Protein-Protein Interactions in the Stat3 Signaling Pathway
- Targeting Nuclear Translocation of Stat3
- Targeting the Binding of Stat3 to the Promoter Region of DNA
- Targeting Stat3 By Natural Bioactive Compounds
- Polyphenols as Inhibitors of Stat3
- Flavonoids as Stat3 Inhibitors
- Flavones in the Regulation of Stat3
- Flavanones in the Regulation of Stat3
- Flavanol in the Regulation of Stat3
- Flavonol in the Regulation of Stat3
- Anthocyanidin in the Regulation of Stat3
- Isoflavonone as Stat3 Inhibitors
- Chalcones as Stat3 Inhibitors
- Other Polyphenols Targeting Stat3
- Non-Polyphenolic Compounds as Inhibitors of Stat3
- Conclusion
- Acknowledgements
- References
Chapter 5 Targeting Cancer Stemness by Exosomes as a Therapeutic Approach Against Ovarian Cancer
- Introduction
- Mechanism of Cancer Stem Cells Leading to Ovarian Cancer And Its Metastatic Sites
- Mitochondrial & Emt Mechanisms on Ovarian Cancer and Its
- Metastatic Sites
- Natural and Small Molecules Targeting Ovarian Cancer
- Exosomes-Based Delivery of Drugs and Other Molecules
- Targeting Ovarian
- Conclusion
- List of Abbreviations
- References
Chapter 6 Sphingosine Kinase as a Target to Treat Gastrointestinal Cancers
- Introduction
- Currently Available Therapies to Treat Gastrointestinal Cancer
- Sphingolipid Metabolism
- Sphingolipid Enzymes
- Sphingosine Kinases
- Ceramidase
- Glucosylceramide Synthase
- Ceramide Synthase
- Importance of Ceramide
- Role of S1P in the Growth of Cancer and Metastasis
- S1P Receptors
- Presence of Sphingolipids in the Digestive System
- Metabolism of Sphingolipids in the Gastrointestinal Tract
- Sphingolipids and Colorectal Tumorigenesis
- Sphingolipids and Intestinal Inflammation
- Sphingolipids in Liver Cancer
- Conclusion
- References
Chapter 7 Hippo Signaling and Its Regulation in Liver Cancer
- Introduction
- Hippo Pathway
- The Mammalian Hippo Pathway
- Hippo Pathway in Cancer
- Hippo Pathway in Liver Cancer
- Association of Hippo and Tumor-Related Pathways
- Hippo and Wnt Pathway
- Hippo and Tgf-Β Pathway
- Hippo and Other Pathways
- Role of Hippo Signaling in Liver Cancer Development
- Role of Key Proteins in Regulating Hippo Pathway
- Role of Mst1 in Liver Cancer
- Effects of Targeting Mst1 Protein During Liver Carcinogenesis
- Role of Yap in Liver Cancer
- Effect of Targeting Yap Protein During Liver Carcinogenesis
- Role of Lats 1/2 in Liver Cancer
- Effects of Targeting Lats1 and Lats2 Protein During Liver Carcinogenesis
- Conclusion
- References
Chapter 8 Immunotoxin: A New Generation Agent for Cancer Treatment
- Introduction
- Mechanism of Action
- Diptheria Toxin (Dt)
- Pseudomonas Exotoxin A
- Immunoconjugates for Cancer Therapy
- Antibody-Drug Conjugates
- Radioimmunoconjugates (RICs)
- The Antibody as a Targeting Moiety
- Ligand as a Target and Cytokine Receptor as a Targeting Moiety
- Growth Factor Receptors as Targets
- Targeting Antigens Associated with Tumors
- The Antibody as a Targeting Moiety
- Her2 Specific Immunotoxins
- Immunotoxins Against Hepatocellular Carcinoma (HCC)
- Immunotoxin Therapy for Lung Cancer
- Immunotoxins for Leukemia
- Immunotoxins for Colorectal Cancer Therapy
- Immunotoxin Therapy of Glioblastoma
- Conclusion
- References
Chapter 9 Multifactorial Drug - a Revolution in the Treatment Of Cancer by Inhibiting Hedgehog Pathway
- Introduction
- Cancer and Hh Pathway
- Hedgehog Signaling and Human Diseases
- Type I- Ligand-Independent Hedgehog Signaling
- Type II- Ligand-Dependent Autocrine/Juxtacrine Signalling
- Type IIIA/B: Ligand-Dependent Hh Signaling in Paracrine Manner
- Hh Signaling Pathway Targets and Multifactorial Drugs
- Inhibitors of Hedgehog Pathway
- Conclusion
- References
Chapter 10 Promising Natural Agents for Targeting MicroRNAs in Cancer
- Introduction
- Mirna Synthesis
- Microrna (Mirnas) in the Development of Tumorigenesis and Carcinogenesis
- Modulation of Mirna Expression in Cancer Using Phytocompounds
- Resveratrol
- Berberine
- Indole-3-Carbinol (I3C)
- Quercetin
Author
- Ashok Kumar Pandurangan
