H2 Receptor Antagonist Global Market Report 2025

The H2 receptor antagonist market size has grown strongly in recent years. It will grow from $4.08 billion in 2024 to $4.32 billion in 2025 at a compound annual growth rate (CAGR) of 5.8%. The growth during the historic period can be attributed to the rising prevalence of peptic ulcers, widespread use of over-the-counter antacids, increasing diagnoses of gastroesophageal reflux disease (GERD), strong adoption in hospital settings, and a rising incidence of gastrointestinal disorders.

The H2 receptor antagonist market size is expected to see strong growth in the next few years. It will grow to $5.35 billion in 2029 at a compound annual growth rate (CAGR) of 5.5%. The projected growth in the forecast period is driven by rising cases of lifestyle-related digestive disorders, increasing demand for non-prescription gastrointestinal treatments, a growing geriatric population with chronic acid issues, expanding availability of generic formulations, and the development of pediatric-friendly formulations. Key trends expected in the forecast period include the development of extended-release formulations, integration with digital health monitoring tools, innovation in pediatric dosage forms, combination therapies with probiotics, and advances in compound stability for hot climates.

The increasing incidence of gastrointestinal diseases is expected to drive the growth of the H2 receptor antagonist market. Gastrointestinal diseases are conditions that affect the digestive tract, including infections, inflammation, and disorders of the stomach and intestines. The rise in gastrointestinal diseases is largely attributed to unhealthy dietary habits and the increasing consumption of processed foods, which can disrupt gut health and lead to digestive disorders such as acid reflux, irritable bowel syndrome (IBS), and ulcers. H2 receptor antagonists address these conditions by blocking histamine receptors in the stomach, reducing acid production, and alleviating symptoms such as acid reflux, ulcers, and gastritis. For example, in January 2023, the American Cancer Society (ACS) reported a 3.18% increase in gastrointestinal cancer cases in the United States, rising from 338,090 in 2022 to 348,840 in 2023. As a result, the growing incidence of gastrointestinal diseases is driving the expansion of the H2 receptor antagonist market.

Companies in the H2 receptor antagonist market are focusing on developing innovative solutions, such as novel drug delivery systems, to improve the efficacy, convenience, and patient compliance of acid-suppressing treatments. Novel drug delivery systems are advanced technologies designed to release therapeutic agents in a controlled, targeted, and sustained manner for enhanced efficacy and better patient adherence. For instance, in June 2022, Zydus Lifesciences Limited, an India-based pharmaceutical company, launched Famotidine ODT, an orally disintegrating tablet for treating acid-related disorders such as GERD. This formulation allows patients, especially those with difficulty swallowing, to take the medication without water, improving convenience and compliance. Zydus highlighted that this innovation supports better treatment outcomes by making the medication easier to use and providing faster relief. The adoption of such delivery systems is helping to drive growth in the H2 receptor antagonist market by enhancing the therapeutic experience and accessibility for patients.

In October 2023, Amgen Inc., a US-based biotechnology company, acquired Horizon Therapeutics plc for $27.8 billion. This acquisition aims to strengthen Amgen’s position in rare diseases and immunology by expanding its portfolio with Horizon's innovative therapies and global commercial capabilities. Horizon Therapeutics, an Ireland-based company, manufactures H2 receptor antagonists, enhancing Amgen’s footprint in the gastrointestinal and inflammation treatment market.

Major players in the h2 receptor antagonist market are Pfizer Inc., Sanofi S.A., Abbott Laboratories, Novartis AG, GlaxoSmithKline plc, Takeda Pharmaceutical Company Limited, Eli Lilly and Company, Viatris Inc., Teva Pharmaceutical Industries Limited, Boehringer Ingelheim International GmbH, Sun Pharmaceutical Industries Limited, Apotex Inc., Aurobindo Pharma Limited, Dr. Reddy's Laboratories Limited, Cipla Limited, Hikma Pharmaceuticals plc, Lupin Ltd., Zydus Lifesciences Limited, Torrent Pharmaceuticals Limited, Accord Healthcare Limited.

North America was the largest region in the H2 receptor antagonist market in 2024. Asia Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in H2 receptor antagonist report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the H2 receptor antagonist market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The H2 receptor antagonist market consists of sales of tegoprazan and lansoprazole. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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