Liquid Chromatography Devices Global Market Report 2025

Liquid chromatography devices are analytical instruments used in liquid chromatography (LC) to separate, identify, and quantify components in a mixture, based on their interactions with a stationary phase and a moving liquid phase. These devices are vital across industries, ensuring product purity and consistency by providing detailed analyses of complex chemical mixtures.

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The main types of liquid chromatography devices include high-performance liquid chromatography (HPLC), ultra-high-performance liquid chromatography (UHPLC), low-pressure liquid chromatography (LPLC), and others. HPLC is an analytical technique that separates, identifies, and quantifies components in a mixture by passing it through a column under high pressure. Accessories for these devices include columns, auto-sampler accessories, and others, with applications spanning pharmaceuticals and biotechnology, food and beverage testing, environmental testing, clinical research, and more.

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The liquid chromatography devices market size has grown strongly in recent years. It will grow from$4.39 billion in 2024 to $4.64 billion in 2025 at a compound annual growth rate (CAGR) of 5.9%. The growth during the historic period can be attributed to the rise of biologics and biosimilars, increasing concerns over food safety and contamination, forensic and toxicology applications, the expansion of academic research in life sciences, and the growing demand for generic drugs.

The liquid chromatography devices market size is expected to see strong growth in the next few years. It will grow to$5.77 billion in 2029 at a compound annual growth rate (CAGR) of 5.6%. The growth in the forecast period can be attributed to the rising demand in the pharmaceutical and biotech industries, a growing focus on personalized medicine, regulatory compliance, and quality control in manufacturing, increasing demand for analytical instruments, and a surge in biopharmaceutical production. Key trends during this period include the integration of automation and AI in chromatography, the incorporation of robotics, miniaturization and portability of systems, cloud-enabled chromatography data systems (CDS), and advancements in column technologies.

The increasing demand for biosimilar products is expected to drive the growth of the liquid chromatography devices market. Biosimilar products are biologic medical products that closely resemble an already approved reference product, with no clinically meaningful differences in terms of safety, effectiveness, or quality. The growth of biosimilars is driven by the need for more affordable alternatives to high-cost biologic drugs, as patents for many original biologics expire, enabling additional manufacturers to produce and market similar versions with comparable efficacy and safety. Liquid chromatography devices play a crucial role in the development and quality control of biosimilars by providing accurate separation, identification, and quantification of complex biological molecules to ensure they are structurally and functionally similar to the reference biologics. For example, in January 2023, Cardinal Health Inc., a U.S.-based healthcare company, reported that the U.S. had 33 FDA-approved biosimilars as of January 2022, with 21 already available on the market. By 2023, the number of FDA-approved biosimilars grew to 40, with 25 commercially available, illustrating significant growth in both approvals and market availability. This growth in biosimilars is driving the expansion of the liquid chromatography devices market.

Leading companies in the liquid chromatography devices market are concentrating on developing cutting-edge products, including next-generation high-performance liquid chromatography (HPLC) systems, to enhance throughput, accuracy, and operational efficiency. A next-generation HPLC system is an advanced analytical tool designed to offer faster separations, greater sensitivity, and better data reproducibility, optimizing laboratory workflows and improving analytical precision. For instance, in October 2024, Agilent Technologies, a U.S.-based biotechnology research company, launched the Agilent InfinityLab LC Series, a next-generation range of high-performance liquid chromatography systems. This innovative platform redefines performance and usability by delivering quicker analysis, lower solvent consumption, and enhanced system intelligence. By incorporating real-time diagnostics and advanced automation features, the InfinityLab LC Series simplifies complex workflows, boosts laboratory productivity, and ensures consistent results.

In January 2022, Bruker Corporation, a U.S.-based manufacturer of high-performance scientific instruments, acquired Prolab Instruments GmbH for an undisclosed amount. This acquisition strengthens Bruker Corporation's research and development capabilities, fostering product innovation and enabling the launch of its mobile injection unit technology. This technology aims to improve performance and robustness in critical applications such as single-cell proteomics and lipidomics. Prolab Instruments GmbH, a Switzerland-based laboratory instrument manufacturer, specializes in providing liquid chromatography devices.

Major players in the liquid chromatography devices market are Hitachi High-Tech Corporation, General Electric Company, Thermo Fisher Scientific Inc., Merck KGaA, Sartorius AG, PerkinElmer Inc., Tosoh Bioscience Inc., Shimadzu Corporation, Revvity Inc., Waters Corporation, Bio-Rad Laboratories Inc., Hamilton Company, Phenomenex Inc., Gilson Incorporated, Trajan Scientific, Restek Corporation, Showa Denko K.K, SCION Instruments Ltd., SIELC Technologies, and JASCO Inc.

North America was the largest region in the liquid chromatography devices market in 2024. The regions covered in liquid chromatography devices report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the liquid chromatography devices market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The liquid chromatography devices market consists of sales of ion chromatography (IC) systems, preparative chromatography systems, chromatography columns, detector systems, fraction collectors, and chromatography software. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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