The calcitonin gene-related peptide (CGRP) inhibitors market size has grown rapidly in recent years. It will grow from $2.87 billion in 2024 to $3.17 billion in 2025 at a compound annual growth rate (CAGR) of 10.6%. The growth during the historic period can be attributed to rising investments in research and development, an increase in the approval of new drugs, growing demand for non-opioid pain relievers, and a stronger emphasis on personalized medicine.
The calcitonin gene-related peptide (CGRP) inhibitors market size is expected to see rapid growth in the next few years. It will grow to $4.68 billion in 2029 at a compound annual growth rate (CAGR) of 10.2%. Growth during the forecast period can be driven by the increasing prevalence of migraines, greater adoption of preventive migraine treatments, rising patient awareness, and higher healthcare expenditures. Key trends expected in the forecast period include advancements in drug formulation technologies, integration of digital health tools, progress in precision medicine, and technological improvements in biosimilars.
The rising occurrence of migraine is anticipated to contribute significantly to the growth of the calcitonin gene-related peptide (CGRP) inhibitors market in the coming years. Migraine is a severe type of headache characterized by pulsating pain, typically affecting one side of the head, and often accompanied by symptoms such as nausea, vomiting, and heightened sensitivity to light and sound. The increasing migraine cases are largely attributed to elevated stress levels, as ongoing stress activates certain neural pathways that can trigger migraine episodes. CGRP inhibitors play a key role in migraine management by providing a targeted and preventative treatment approach that fits both acute and long-term care strategies. These medications reduce the frequency and intensity of migraine attacks by effectively blocking CGRP receptors, leading to improved quality of life and enhanced daily performance. For example, in January 2023, the National Library of Medicine, a U.S.-based health information agency, reported that migraines affect between 14% and 15% of the global population and account for 4.9% of the global disease burden. Hence, the growing incidence of migraine is boosting demand in the CGRP inhibitors market.
Leading companies in the CGRP inhibitors space are investing in innovative therapies and seeking regulatory approvals for advanced treatment options, such as CGRP receptor antagonists, to enhance migraine relief, broaden clinical use, and provide user-friendly delivery methods like oral or intranasal formulations. A CGRP receptor antagonist is a type of medication that prevents migraine pain by inhibiting CGRP receptor activity. For instance, in April 2023, AbbVie Inc., a biotech firm based in the U.S., obtained approval from the U.S. Food and Drug Administration (FDA) for QULIPTA (atogepant) for the preventive treatment of chronic migraine in adults. QULIPTA is an oral CGRP receptor antagonist that works by blocking CGRP pathways involved in migraine pathogenesis, thereby reducing the occurrence of migraine episodes.
In October 2022, Pfizer Inc., a U.S.-based pharmaceutical company, acquired Biohaven Pharmaceutical Holding Company Ltd. for roughly $11.6 billion. This acquisition was aimed at expanding Pfizer’s portfolio of migraine therapies and supporting long-term market growth by integrating Biohaven’s innovative CGRP-targeted treatments with Pfizer’s extensive global infrastructure. Biohaven Pharmaceutical Holding Company Ltd. is a U.S.-based biopharmaceutical firm known for its work in developing CGRP inhibitors for migraine management.
Major players in the calcitonin gene-related peptide (cgrp) inhibitors market are Pfizer Inc., F. Hoffmann-La Roche AG, Merck & Co. Inc., AbbVie Inc., Bristol Myers Squibb Company, AstraZeneca plc, Novartis AG, Eli Lilly and Company, Amgen Inc., Otsuka Holdings Co. Ltd., Teva Pharmaceutical Industries Ltd., H. Lundbeck A/S, Kissei Pharmaceutical Co. Ltd., Shanghai Junshi Biosciences Co. Ltd., Shin Nippon Biomedical Laboratories Ltd., Sosei Group Corporation, Nuvie Bio Inc., Vaxxinity Inc., Acherx LLC, AfaSci Inc.
North America was the largest region in the calcitonin gene-related peptide (CGRP) inhibitors market in 2024. Asia Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in calcitonin gene-related peptide (CGRP) inhibitors report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the calcitonin gene-related peptide (CGRP) inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
Calcitonin gene-related peptide (CGRP) inhibitors are a category of drugs that block the function of the CGRP pathway, which plays a role in transmitting pain and widening blood vessels in the brain. These inhibitors help to decrease both the frequency and intensity of migraines and are used as a treatment for patients suffering from chronic or episodic migraines.
The primary types of CGRP inhibitors include monoclonal antibodies, small molecules, and peptides. Monoclonal antibodies are lab-engineered molecules designed to bind specifically to a single target, such as a protein or receptor in the body. Their mechanisms of action involve anti-CGRP ligand therapies and CGRP receptor antagonists. Administration methods vary and include oral, nasal, and intravenous routes. Treatment options are categorized into preventive and acute therapies for migraines. End users of these treatments include hospitals, specialty clinics, mail-order pharmacies, and retail pharmacies.
The calcitonin gene-related peptide (CGRP) inhibitors market research report is one of a series of new reports that provides calcitonin gene-related peptide (CGRP) inhibitors market statistics, including calcitonin gene-related peptide (CGRP) inhibitors industry global market size, regional shares, competitors with a calcitonin gene-related peptide (CGRP) inhibitors market share, detailed calcitonin gene-related peptide (CGRP) inhibitors market segments, market trends and opportunities, and any further data you may need to thrive in the calcitonin gene-related peptide (CGRP) inhibitors industry. This calcitonin gene-related peptide (CGRP) inhibitors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The calcitonin gene-related peptide (CGRP) inhibitors market consists of sales of aimovig, emgality, ubrogepant, rimegepant, atogepant, and ajovy. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
This product will be delivered within 3-5 business days.
The calcitonin gene-related peptide (CGRP) inhibitors market size is expected to see rapid growth in the next few years. It will grow to $4.68 billion in 2029 at a compound annual growth rate (CAGR) of 10.2%. Growth during the forecast period can be driven by the increasing prevalence of migraines, greater adoption of preventive migraine treatments, rising patient awareness, and higher healthcare expenditures. Key trends expected in the forecast period include advancements in drug formulation technologies, integration of digital health tools, progress in precision medicine, and technological improvements in biosimilars.
The rising occurrence of migraine is anticipated to contribute significantly to the growth of the calcitonin gene-related peptide (CGRP) inhibitors market in the coming years. Migraine is a severe type of headache characterized by pulsating pain, typically affecting one side of the head, and often accompanied by symptoms such as nausea, vomiting, and heightened sensitivity to light and sound. The increasing migraine cases are largely attributed to elevated stress levels, as ongoing stress activates certain neural pathways that can trigger migraine episodes. CGRP inhibitors play a key role in migraine management by providing a targeted and preventative treatment approach that fits both acute and long-term care strategies. These medications reduce the frequency and intensity of migraine attacks by effectively blocking CGRP receptors, leading to improved quality of life and enhanced daily performance. For example, in January 2023, the National Library of Medicine, a U.S.-based health information agency, reported that migraines affect between 14% and 15% of the global population and account for 4.9% of the global disease burden. Hence, the growing incidence of migraine is boosting demand in the CGRP inhibitors market.
Leading companies in the CGRP inhibitors space are investing in innovative therapies and seeking regulatory approvals for advanced treatment options, such as CGRP receptor antagonists, to enhance migraine relief, broaden clinical use, and provide user-friendly delivery methods like oral or intranasal formulations. A CGRP receptor antagonist is a type of medication that prevents migraine pain by inhibiting CGRP receptor activity. For instance, in April 2023, AbbVie Inc., a biotech firm based in the U.S., obtained approval from the U.S. Food and Drug Administration (FDA) for QULIPTA (atogepant) for the preventive treatment of chronic migraine in adults. QULIPTA is an oral CGRP receptor antagonist that works by blocking CGRP pathways involved in migraine pathogenesis, thereby reducing the occurrence of migraine episodes.
In October 2022, Pfizer Inc., a U.S.-based pharmaceutical company, acquired Biohaven Pharmaceutical Holding Company Ltd. for roughly $11.6 billion. This acquisition was aimed at expanding Pfizer’s portfolio of migraine therapies and supporting long-term market growth by integrating Biohaven’s innovative CGRP-targeted treatments with Pfizer’s extensive global infrastructure. Biohaven Pharmaceutical Holding Company Ltd. is a U.S.-based biopharmaceutical firm known for its work in developing CGRP inhibitors for migraine management.
Major players in the calcitonin gene-related peptide (cgrp) inhibitors market are Pfizer Inc., F. Hoffmann-La Roche AG, Merck & Co. Inc., AbbVie Inc., Bristol Myers Squibb Company, AstraZeneca plc, Novartis AG, Eli Lilly and Company, Amgen Inc., Otsuka Holdings Co. Ltd., Teva Pharmaceutical Industries Ltd., H. Lundbeck A/S, Kissei Pharmaceutical Co. Ltd., Shanghai Junshi Biosciences Co. Ltd., Shin Nippon Biomedical Laboratories Ltd., Sosei Group Corporation, Nuvie Bio Inc., Vaxxinity Inc., Acherx LLC, AfaSci Inc.
North America was the largest region in the calcitonin gene-related peptide (CGRP) inhibitors market in 2024. Asia Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in calcitonin gene-related peptide (CGRP) inhibitors report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the calcitonin gene-related peptide (CGRP) inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
Calcitonin gene-related peptide (CGRP) inhibitors are a category of drugs that block the function of the CGRP pathway, which plays a role in transmitting pain and widening blood vessels in the brain. These inhibitors help to decrease both the frequency and intensity of migraines and are used as a treatment for patients suffering from chronic or episodic migraines.
The primary types of CGRP inhibitors include monoclonal antibodies, small molecules, and peptides. Monoclonal antibodies are lab-engineered molecules designed to bind specifically to a single target, such as a protein or receptor in the body. Their mechanisms of action involve anti-CGRP ligand therapies and CGRP receptor antagonists. Administration methods vary and include oral, nasal, and intravenous routes. Treatment options are categorized into preventive and acute therapies for migraines. End users of these treatments include hospitals, specialty clinics, mail-order pharmacies, and retail pharmacies.
The calcitonin gene-related peptide (CGRP) inhibitors market research report is one of a series of new reports that provides calcitonin gene-related peptide (CGRP) inhibitors market statistics, including calcitonin gene-related peptide (CGRP) inhibitors industry global market size, regional shares, competitors with a calcitonin gene-related peptide (CGRP) inhibitors market share, detailed calcitonin gene-related peptide (CGRP) inhibitors market segments, market trends and opportunities, and any further data you may need to thrive in the calcitonin gene-related peptide (CGRP) inhibitors industry. This calcitonin gene-related peptide (CGRP) inhibitors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The calcitonin gene-related peptide (CGRP) inhibitors market consists of sales of aimovig, emgality, ubrogepant, rimegepant, atogepant, and ajovy. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
This product will be delivered within 3-5 business days.
Table of Contents
1. Executive Summary2. Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market Characteristics3. Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market Trends And Strategies4. Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market - Macro Economic Scenario Including The Impact Of Interest Rates, Inflation, Geopolitics, Trade Wars and Tariffs, And Covid And Recovery On The Market32. Global Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market Competitive Benchmarking And Dashboard33. Key Mergers And Acquisitions In The Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market34. Recent Developments In The Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
5. Global Calcitonin Gene-Related Peptide (CGRP) Inhibitors Growth Analysis And Strategic Analysis Framework
6. Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market Segmentation
7. Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market Regional And Country Analysis
8. Asia-Pacific Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
9. China Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
10. India Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
11. Japan Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
12. Australia Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
13. Indonesia Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
14. South Korea Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
15. Western Europe Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
16. UK Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
17. Germany Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
18. France Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
19. Italy Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
20. Spain Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
21. Eastern Europe Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
22. Russia Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
23. North America Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
24. USA Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
25. Canada Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
26. South America Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
27. Brazil Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
28. Middle East Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
29. Africa Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market
30. Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market Competitive Landscape And Company Profiles
31. Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market Other Major And Innovative Companies
35. Calcitonin Gene-Related Peptide (CGRP) Inhibitors Market High Potential Countries, Segments and Strategies
36. Appendix
Executive Summary
Calcitonin Gene-Related Peptide (CGRP) Inhibitors Global Market Report 2025 provides strategists, marketers and senior management with the critical information they need to assess the market.This report focuses on calcitonin gene-related peptide (cgrp) inhibitors market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
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Description
Where is the largest and fastest growing market for calcitonin gene-related peptide (cgrp) inhibitors ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The calcitonin gene-related peptide (cgrp) inhibitors market global report answers all these questions and many more.The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market’s historic and forecast market growth by geography.
- The market characteristics section of the report defines and explains the market.
- The market size section gives the market size ($b) covering both the historic growth of the market, and forecasting its development.
- The forecasts are made after considering the major factors currently impacting the market. These include:
- The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.
- Market segmentations break down the market into sub markets.
- The regional and country breakdowns section gives an analysis of the market in each geography and the size of the market by geography and compares their historic and forecast growth. It covers the growth trajectory of COVID-19 for all regions, key developed countries and major emerging markets.
- The competitive landscape chapter gives a description of the competitive nature of the market, market shares, and a description of the leading companies. Key financial deals which have shaped the market in recent years are identified.
- The trends and strategies section analyses the shape of the market as it emerges from the crisis and suggests how companies can grow as the market recovers.
Scope
Markets Covered:
1) By Type Of Inhibitor: Monoclonal Antibodies; Small Molecules; Peptides2) By Mechanism Of Action: Anti-Calcitonin Gene-Related Peptide (CGRP) Ligand; Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist
3) By Route of Administration: Oral; Nasal; Intravenous
4) By Treatment: Preventive Migraine Treatment; Acute Migraine Treatment
5) By End User: Hospitals; Specialty Clinics; Mail Order Pharmacies; Retail Pharmacies
Subsegments:
1) By Monoclonal Antibodies: Erenumab (Aimovig); Eptinezumab (Vyepti); Fremanezumab (Ajovy); Galcanezumab (Emgality)2) By Small Molecules: Ubrogepant; Rimegepant; Atogepant; Zavegepant
3) By Peptides: Calcitonin Gene-Related Peptide (CGRP) Antagonist Peptides; Modified Calcitonin Gene-Related Peptide (CGRP) Analogs; Intranasal Peptide Formulations; Peptide-Based Delivery Systems
Key Companies Profiled: Pfizer Inc.; F. Hoffmann-La Roche AG; Merck & Co. Inc.; AbbVie Inc.; Bristol Myers Squibb Company
Countries: Australia; Brazil; China; France; Germany; India; Indonesia; Japan; Russia; South Korea; UK; USA; Canada; Italy; Spain
Regions: Asia-Pacific; Western Europe; Eastern Europe; North America; South America; Middle East; Africa
Time Series: Five years historic and ten years forecast.
Data: Ratios of market size and growth to related markets, GDP proportions, expenditure per capita.
Data Segmentation: Country and regional historic and forecast data, market share of competitors, market segments.
Sourcing and Referencing: Data and analysis throughout the report is sourced using end notes.
Delivery Format: PDF, Word and Excel Data Dashboard.
Companies Mentioned
- Pfizer Inc.
- F. Hoffmann-La Roche AG
- Merck & Co. Inc.
- AbbVie Inc.
- Bristol Myers Squibb Company
- AstraZeneca plc
- Novartis AG
- Eli Lilly and Company
- Amgen Inc.
- Otsuka Holdings Co. Ltd.
- Teva Pharmaceutical Industries Ltd.
- H. Lundbeck A/S
- Kissei Pharmaceutical Co. Ltd.
- Shanghai Junshi Biosciences Co. Ltd.
- Shin Nippon Biomedical Laboratories Ltd.
- Sosei Group Corporation
- Nuvie Bio Inc.
- Vaxxinity Inc.
- Acherx LLC
- AfaSci Inc.