Nexobrid Market Report 2026: Epidemiology, Pipeline Analysis, Market Insights & Forecasts

The growth in the historic period can be attributed to increasing incidence of severe burn injuries, limitations of surgical debridement methods, expansion of specialized burn care units, rising awareness of advanced wound care therapies, improved access to topical enzymatic treatments.

The growth in the forecast period can be attributed to increasing demand for minimally invasive wound management, expansion of trauma care infrastructure, growing adoption of advanced enzymatic formulations, rising focus on patient recovery outcomes, increasing investments in next-generation burn care technologies. Major trends in the forecast period include increasing adoption of enzymatic burn debridement solutions, rising demand for non-surgical burn care treatments, growing focus on accelerated wound healing, expansion of advanced trauma and burn centers, enhanced emphasis on tissue preservation.

The increasing prevalence of burn injuries is expected to drive the growth of the Nexobrid market going forward. Burn injuries involve physical damage to the skin or other tissues, leading to pain, tissue destruction, and impaired function. Occupational hazards in industries such as construction, manufacturing, and healthcare increase the risk of burns due to exposure to open flames, hot surfaces, and hazardous chemicals. Nexobrid supports burn recovery by efficiently removing eschar from burn wounds, accelerating healing, and reducing the need for surgery, thereby improving patient outcomes. For instance, in October 2023, the World Health Organization reported that approximately 180,000 deaths occur annually due to burns, with the majority occurring in low- and middle-income countries. Therefore, the rising prevalence of burn injuries is fueling the growth of the Nexobrid market.

Major companies in the Nexobrid market are focusing on developing innovative solutions, such as eschar removal drugs, to meet the increasing demand for effective, non-invasive burn care. These drugs break down dead tissue (eschar) while preserving healthy tissue, offering a non-surgical alternative to traditional debridement. For instance, in August 2024, MediWound Ltd., an Israel-based biopharmaceutical company, announced U.S. FDA approval of NexoBrid (anacaulase-bcdb) for pediatric patients with deep partial-thickness or full-thickness thermal burns. The product features a proteolytic enzyme formulation that removes burn eschar within four hours, supports tissue regeneration, and reduces the need for surgical intervention. NexoBrid is approved in over 43 countries and is supported by BARDA.

In November 2024, MediWound Ltd. partnered with PolyMedics Innovations to enhance wound care solutions. This partnership aims to expand the commercial reach of NexoBrid across key European markets, increase adoption in burn care centers, and complement PMI’s existing wound-healing product portfolio. PolyMedics Innovations GmbH, based in Germany, provides advanced wound care and skin substitute solutions, including products such as SUPRATHEL and NovoSorb BTM.

Major companies operating in the nexobrid market are MediWound Ltd.

North America was the largest region in the nexobrid market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the nexobrid market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the nexobrid market report are Australia, India, China, South Korea, Japan, UK, France, Germany, USA, Canada.

Tariffs are impacting the nexobrid market by increasing costs of imported enzymatic compounds, pharmaceutical excipients, specialized packaging materials, and temperature-controlled logistics required for topical burn care products. Hospitals and trauma centers in North America and Europe are most affected due to reliance on international manufacturing and distribution networks, while developing regions face affordability constraints. These tariffs are raising treatment costs and influencing procurement decisions. However, they are also encouraging localized production, regional packaging operations, and long-term investment in domestic wound care manufacturing capabilities.

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Nexobrid is a topical enzymatic debridement agent developed for the treatment of severe burns. It selectively removes eschar while preserving healthy tissue, promoting faster wound healing and reducing the need for surgical interventions. This advanced formulation supports improved recovery outcomes and provides a non-invasive approach to burn care.

The main formulations of Nexobrid include topical gel, spray, and ointment. Topical gel is applied directly to the skin, delivering active ingredients efficiently to the affected area to promote healing. Nexobrid is used in clinical indications such as burn care, chronic wound care, and trauma care. It is distributed through hospitals, ambulatory surgical centers (ASCs), retail pharmacies, and online pharmacies, and is used by adults, pediatric, and geriatric patients.

The nexobrid market consists of sales of cream, liquid solution, and powder. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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