High-Performance Liquid Chromatography (HPLC) Solvent Market Report 2026

The high-performance liquid chromatography (hplc) solvent market size has grown strongly in recent years. It will grow from $0.78 billion in 2025 to $0.84 billion in 2026 at a compound annual growth rate (CAGR) of 7.2%. The growth in the historic period can be attributed to pharmaceutical r&d expansion, academic research growth, chromatography standardization, chemical purity regulations, laboratory infrastructure development.

The high-performance liquid chromatography (hplc) solvent market size is expected to see strong growth in the next few years. It will grow to $1.09 billion in 2030 at a compound annual growth rate (CAGR) of 6.9%. The growth in the forecast period can be attributed to biopharmaceutical pipeline growth, precision medicine adoption, contract research expansion, stricter analytical regulations, advanced separation techniques. Major trends in the forecast period include rising demand for high purity analytical solvents, growing use in pharmaceutical quality testing, expansion of biotech and life sciences research, increased adoption of reverse phase hplc, focus on low impurity and trace metal control.

The increasing demand for biopharmaceuticals is expected to drive the growth of the high-performance liquid chromatography (HPLC) solvent market in the coming years. Biopharmaceuticals are defined as medicinal products developed using biotechnology, including proteins, nucleic acids, or living cells for therapeutic or diagnostic applications. The demand for biopharmaceuticals is rising due to the growing need for targeted and personalized therapies that deliver improved efficacy and reduced side effects compared to conventional drugs. High-performance liquid chromatography (HPLC) solvents play a vital role in biopharmaceuticals by enabling accurate separation and analysis of complex biomolecules, thereby ensuring product purity and quality. For instance, in July 2025, according to Sartorius, a Germany-based international life science technology company, global biopharmaceutical drug sales increased by approximately 9% to reach USD 458 billion in 2024, up from the previous year, accounting for 41% of the total pharmaceutical market compared with 40% in 2023. Therefore, the growing demand for biopharmaceuticals is fueling the expansion of the high-performance liquid chromatography (HPLC) solvent market.

Major companies operating in the high-performance liquid chromatography (HPLC) solvent market are emphasizing the development of advanced solutions, such as bio-inert sample flow paths, to improve measurement accuracy, minimize assay errors, and enhance reproducibility in complex analytical workflows. Bio-inert flow paths are chromatographic system components engineered without metal or adsorptive surfaces to reduce sample interaction, degradation, or adsorption. For instance, in April 2024, Waters Corporation, a US-based biotechnology and laboratory equipment company, introduced the Alliance iS Bio HPLC System to support biopharmaceutical quality control laboratories in improving efficiency and reducing operational errors. The system incorporates integrated solvent management, automated degassing, accurate gradient delivery, and user-friendly software for method configuration and monitoring; it operates by maintaining consistent solvent composition and flow to achieve high-precision chromatographic analysis; distinguishing features include real-time solvent monitoring, automated error notifications, and compatibility with a broad range of bioanalytical methods; applications include biopharmaceutical quality control, drug development, and complex sample analysis; key benefits include enhanced analytical reliability, reduced manual handling, higher throughput, and a lower risk of solvent-related errors.

In April 2025, Bruker Corporation, a US-based scientific instruments and life sciences technology company, acquired a majority stake in RECIPE Chemicals + Instruments GmbH for an undisclosed amount. Through this acquisition, Bruker seeks to expand its mass spectrometry-based diagnostic offerings and reinforce its presence in therapeutic drug monitoring markets. RECIPE Chemicals + Instruments GmbH is a Germany-based diagnostics company specializing in the development of mass spectrometry-based diagnostic assay kits for therapeutic drug monitoring.

Major companies operating in the high-performance liquid chromatography (hplc) solvent market are Merck KGaA, Thermo Fisher Scientific Inc., Honeywell International Inc., Mitsubishi Chemical Corporation, Avantor Inc., Agilent Technologies Inc., Actylis, Spectrum Chemical Manufacturing Corporation, Tedia Company Inc., Tokyo Chemical Industry Co., Ltd., CovaChem LLC, Fujifilm Corporation, Kanto Chemical Co., Inc., LGC Standards Ltd., Antylia Scientific, Central Drug House (P) Ltd., SRL Limited, Scharlab S.L., MP Biomedicals, LLC, GFS Chemicals, Inc., PanReac Química S.L.U.

North America was the largest region in the high-performance liquid chromatography (HPLC) solvent market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the high-performance liquid chromatography (hplc) solvent market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the high-performance liquid chromatography (hplc) solvent market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The high-performance liquid chromatography (HPLC) solvent market consists of sales of isocratic solvents, gradient solvents, and aqueous solvents. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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