High-Performance Liquid Chromatography (HPLC) Solvent Global Market Report 2025

The high-performance liquid chromatography (HPLC) solvent market size has grown strongly in recent years. It will grow from $0.73 billion in 2024 to $0.78 billion in 2025 at a compound annual growth rate (CAGR) of 7.2%. The growth observed during the historical period can be attributed to the expansion of pharmaceutical R&D, increased applications in biotechnology and life sciences, a focus on food safety and quality, heightened environmental monitoring, and growth in clinical and diagnostic uses.

The high-performance liquid chromatography (HPLC) solvent market size is expected to see strong growth in the next few years. It will grow to $1.03 billion in 2029 at a compound annual growth rate (CAGR) of 7%. The projected growth in the forecast period is driven by the rising prevalence of chronic and emerging diseases, an increase in drug development initiatives, growing demand for forensic and toxicological testing, expansion of clinical diagnostics, and a surge in biopharmaceutical manufacturing. Key trends expected in the forecast period include the adoption of advanced chromatography techniques, the development of eco-friendly and low-toxicity solvents, greater use of automation, AI, and smart technologies in solvent production and quality control, a shift toward green and bio-based solvents, and innovations in solvent packaging.

The rising demand for biopharmaceuticals is expected to drive the growth of the high-performance liquid chromatography (HPLC) solvent market moving forward. Biopharmaceuticals are medical drugs produced through biotechnology, including proteins, nucleic acids, or living cells used for therapeutic or diagnostic applications. The growth in biopharmaceuticals is fueled by the increasing need for targeted and personalized therapies that provide greater efficacy and fewer side effects compared to conventional drugs. High-performance liquid chromatography (HPLC) solvents are vital in biopharmaceuticals, enabling precise separation and analysis of complex biomolecules to ensure purity and quality of products. For example, in January 2023, Dubai World Trade Centre, a UAE-based conference center with 23 manufacturing sites and 2,500 locally produced medicines, projected the UAE pharmaceutical market to reach $4.7 billion by 2025. Additionally, in 2022, according to phrma.org, a US-based trade association, the U.S. biopharmaceutical industry generated over $800 billion in direct output, with significant economic ripple effects across the country. Thus, the growing demand for biopharmaceuticals is driving the expansion of the high-performance liquid chromatography (HPLC) solvent market.

Key companies in the high-performance liquid chromatography (HPLC) solvent market are concentrating on developing innovative solutions, such as metal-free sample paths, to improve analytical accuracy, increase sensitivity, prevent sample adsorption and corrosion, and enhance system durability when using aggressive or high-concentration mobile phases. Metal-free sample paths refer to chromatographic system parts designed without metal components in contact with samples or solvents to avoid adsorption and corrosion. For instance, in June 2022, Shimadzu Scientific Instruments, a Japan-based manufacturer of industrial and testing equipment, launched the Nexera XS inert UHPLC system to improve performance in analyzing sensitive samples. This system tackles issues like sample adsorption and corrosion caused by aggressive or high-concentration mobile phases while maintaining the high performance and modular expandability of the existing Nexera Series. Its inert design delivers enhanced accuracy, sensitivity, and durability, making it ideal for applications that require metal-free sample flow paths, such as biomolecule analysis.

In January 2022, Bruker Corporation, a US-based scientific instrument manufacturer, acquired Prolab Instruments GmbH for an undisclosed amount. Through this acquisition, Bruker aims to strengthen its expertise in low-flow, high-precision liquid chromatography systems and expand its analytical instrumentation portfolio. Prolab Instruments GmbH, based in Switzerland, specializes in low-flow, high-precision liquid chromatography technology and supplies high-performance liquid chromatography (HPLC) solvents.

Major players in the high-performance liquid chromatography (hplc) solvent market are Merck KGaA, Thermo Fisher Scientific Inc., Honeywell International Inc., Mitsubishi Chemical Corporation, Danaher Corporation, DuPont de Nemours Inc., Avantor Inc., Agilent Technologies Inc., Hitachi High-Technologies Corporation, Sartorius AG, Sigma-Aldrich Co. LLC, Shimadzu Corporation, Revvity Inc., Waters Corporation, Bio-Rad Laboratories Inc., Bruker Corporation, Actylis, Spectrum Chemical Manufacturing Corporation, Gilson Inc., Tedia Company Inc., Tokyo Chemical Industry Co. Ltd. (India) Pvt. Ltd., and CovaChem LLC.

North America was the largest region in the high-performance liquid chromatography (HPLC) solvent market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in high-performance liquid chromatography (HPLC) solvent report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the high-performance liquid chromatography (HPLC) solvent market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

High-performance liquid chromatography (HPLC) solvents are high-purity liquids used as the mobile phase in HPLC systems to separate and analyze compounds within a mixture. They facilitate the movement of analytes through the column with minimal interference, ensuring accurate and consistent analytical results.

The primary categories of HPLC solvents include polar and non-polar solvents. Polar solvents consist of molecules with a significant electric dipole moment, allowing them to effectively dissolve ionic and other polar substances. The main product types include normal phase HPLC and reverse phase HPLC, which find applications across industries such as pharmaceuticals, biotechnology, life sciences, environmental testing, and more.

The high-performance liquid chromatography (HPLC) solvent market research report is one of a series of new reports that provides high-performance liquid chromatography (HPLC) solvent market statistics, including the high-performance liquid chromatography (HPLC) solvent industry global market size, regional shares, competitors with the high-performance liquid chromatography (HPLC) solvent market share, detailed high-performance liquid chromatography (HPLC) solvent market segments, market trends, and opportunities, and any further data you may need to thrive in the high-performance liquid chromatography (HPLC) solvent industry. This high-performance liquid chromatography (HPLC) solvent market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The high-performance liquid chromatography (HPLC) solvent market consists of sales of isocratic solvents, gradient solvents, and aqueous solvents. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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