Size Exclusion Chromatography (SEC) HPLC Column Global Market Report 2025

The size exclusion chromatography (SEC) HPLC column market size has grown strongly in recent years. It will grow from $0.46 billion in 2024 to $0.51 billion in 2025 at a compound annual growth rate (CAGR) of 9.9%. The expansion during the past years is mainly due to the rising use of SEC for determining molecular weight, the increasing incidence of chronic illnesses driving drug discovery efforts, the growing application of SEC in the food and beverage sector for quality assurance, enhanced government investments in research and development, and the growth of biopharmaceutical contract research organizations.

The size of the size exclusion chromatography (SEC) HPLC column market is expected to see strong growth in the next few years. It will grow to $0.73 billion in 2029 at a compound annual growth rate (CAGR) of 9.5%. This growth is supported by rising demand for protein purification within biopharmaceuticals, expansion of the biotechnology and pharmaceutical sectors, increased research activities in life sciences, development in personalized medicine and biologics, and heightened focus on polymer characterization. Key trends anticipated in the coming years include advancements in chromatographic technologies, innovations such as ultrahigh-pressure SEC columns, growing adoption of multi-dimensional chromatography methods integrating SEC, increased preference for affordable and dependable chromatography solutions, and the rising tendency to outsource analytical testing to specialized laboratories.

The growing demand for personalized medication is anticipated to drive the expansion of the size exclusion chromatography (SEC) HPLC column market in the coming years. Personalized medication involves customizing medical treatments based on an individual's genetic profile, lifestyle, and health status to achieve optimal and safe results. This rising demand is fueled by advances in genetics and the increasing need for more precise, tailored therapies. SEC HPLC columns play a crucial role in accurately assessing the molecular size and aggregation of therapeutic proteins, which is vital for ensuring the safety and effectiveness of personalized treatments. For example, according to the Personalized Medicine Coalition, a US-based non-profit, the US Food and Drug Administration (FDA) approved 16 new personalized therapies for rare diseases in 2023, a marked increase from the six approvals in 2022. Hence, the growing need for personalized medication is expected to stimulate growth in the SEC HPLC column market.

Leading companies in the size exclusion chromatography (SEC) HPLC column market are concentrating on developing advanced technologies such as multi-attribute quantification methods to tackle key challenges in gene therapy development. These methods allow the simultaneous analysis of multiple attributes, enhancing precision and efficiency. For instance, in August 2023, Waters Corporation, a US laboratory instrument manufacturer, introduced the XBridge Premier GTx BEH SEC columns designed to improve analysis and reduce costs for gene therapies, especially those involving adeno-associated viral (AAV) vectors. These columns offer significant advantages, including reducing sample requirements by 3 to 10 times, doubling analytical speed, and enhancing sensitivity and resolution. Their innovative design supports process development, formulation analysis, regulatory evaluation, and quality control, enabling faster, more detailed, and cost-effective analysis of AAVs and other large biomolecules, thereby advancing gene therapy research and production.

In August 2022, Agilent Technologies Inc., a US-based manufacturer of analytical instruments, acquired Polymer Standards Service (PSS) for an undisclosed sum. This acquisition expanded Agilent’s product portfolio and strengthened its offerings to clients in the chemical and biopharmaceutical sectors, especially for analyzing natural and synthetic polymers such as nucleic acids, proteins, monoclonal antibodies, polysaccharides, and synthetic plastics. Polymer Standards Service (PSS), based in Germany, is a manufacturer of size exclusion chromatography (SEC) HPLC columns.

Major players in the size exclusion chromatography (sec) hplc column market are Merck & Co. Inc., Thermo Fisher Scientific Inc., Danaher Corporation, Agilent Technologies Inc., Sartorius AG, PerkinElmer Inc., Shimadzu Corporation, Waters Corporation, Bio-Rad Laboratories Inc., Malvern Panalytical Ltd., Buchi Labortechnik AG, Phenomenex Inc., Tosoh Bioscience LLC, Knauer, JASCO Inc., Sepax Technologies Inc., SIELC Technologies, Eprogen Inc., Wyatt Technology, MZ-Analysentechnik GmbH.

North America was the largest region in the size exclusion chromatography (SEC) HPLC column market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in size exclusion chromatography (SEC) HPLC column report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the size exclusion chromatography (SEC) HPLC column market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

A size exclusion chromatography (SEC) HPLC column is a chromatographic column specifically designed to separate molecules based on their size in solution. It operates on the principle of molecular sieving, where a porous stationary phase allows smaller molecules to enter the pores and be retained longer, while larger molecules elute more quickly as they are excluded from the pores. This technique is widely used to analyze and purify polymers, proteins, and other macromolecules, providing information about molecular weight distribution and aggregation.

The main types of size exclusion chromatography (SEC) HPLC columns include standard size exclusion chromatography (SEC) columns, high-resolution size exclusion chromatography (SEC) columns, ultra-high-performance size exclusion chromatography (SEC) columns, and 2D size exclusion chromatography (SEC) columns. Standard SEC columns utilize a stationary phase that helps separate molecules primarily by size, offering moderate resolution. It is made using various types of materials such as organic solvents, polymeric materials, silica-based materials, and modified silica particles and is applied for biopharmaceutical analysis, protein purification, nucleic acid analysis, and polymer characterization. It is used by various end-users such as the pharmaceutical industry, academic and research institutions, biotechnology firms, and environmental testing laboratories.

The size exclusion chromatography (SEC) HPLC column market research report is one of a series of new reports that provides size exclusion chromatography (SEC) HPLC column market statistics, including size exclusion chromatography (SEC) HPLC column industry global market size, regional shares, competitors with a size exclusion chromatography (SEC) HPLC column market share, detailed size exclusion chromatography (SEC) HPLC column market segments, market trends and opportunities, and any further data you may need to thrive in the size exclusion chromatography (SEC) HPLC column industry. This size exclusion chromatography (SEC) HPLC column market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The size exclusion chromatography (SEC) HPLC column market consists of sales of pre-packed columns, chromatography resins, sample preparation kits, and column fittings. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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