Mastocytosis Drug Global Market Report 2025

The mastocytosis drug market size has grown strongly in recent years. It will grow from $1.07 billion in 2024 to $1.17 billion in 2025 at a compound annual growth rate (CAGR) of 9.8%. The growth during the historic period can be attributed to an aging population, a rising prevalence of blood cancers, increased utilization of biologic and immunotherapies, growing healthcare spending, and a higher incidence of mastocytosis.

The mastocytosis drug market size is expected to see strong growth in the next few years. It will grow to $1.68 billion in 2029 at a compound annual growth rate (CAGR) of 9.5%. The projected growth during the forecast period can be attributed to a growing emphasis on rare disease treatments, the emergence of personalized medicine, an increasing incidence of allergies and immune system disorders, greater use of supportive therapies, and an expanding pipeline of drugs in development. Key trends anticipated during this period include progress in medical research, the development of targeted treatment options, advancements in genetic research, the adoption of combination therapy approaches, and innovations in drug delivery technologies.

The rising investment in rare diseases is expected to drive the growth of the mastocytosis drug market in the coming years. Rare diseases are medical conditions that impact a small portion of the population - typically fewer than 200,000 individuals in the United States or fewer than 1 in 2,000 people in Europe. Increased investment in this area is largely fueled by growing regulatory incentives such as orphan drug designations, extended market exclusivity, and tax credits, which help lower development risks and improve profitability for pharmaceutical companies. Mastocytosis drugs provide targeted treatment that not only helps manage mastocytosis symptoms but also contributes to the advancement of therapies for other rare diseases sharing similar immune or cellular pathways. For example, in April 2024, Global Genes, a US-based nonprofit organization, reported that in the first quarter of 2024, companies focused on rare disease drug development raised $7.1 billion through public equity and debt financings - a 307% increase compared to the $1.8 billion raised during the same period in 2023. As a result, rising investment in rare diseases is fueling the expansion of the mastocytosis drug market.

Leading companies in the mastocytosis drug market are concentrating on developing innovative treatments such as tyrosine kinase inhibitors to enhance therapeutic effectiveness and offer targeted solutions for patients with advanced mast cell disorders. Tyrosine kinase inhibitors are medications that block enzymes involved in abnormal cell growth. In the context of mastocytosis, these drugs work by inhibiting the excessive growth of mast cells, thereby reducing symptoms like rashes and inflammation. For example, in May 2023, Blueprint Medicines Corporation, a biotechnology company based in the U.S., received approval from the U.S. Food and Drug Administration for Ayvakit (avapritinib) to treat adults with indolent systemic mastocytosis (ISM). This approval represents a significant step forward in managing ISM, a rare and chronic condition marked by the overproduction of mast cells. Ayvakit is a selective inhibitor targeting the KIT D816V mutation, which is commonly found in ISM patients, providing a focused treatment option for symptom control and disease management.

In May 2024, Incyte Corporation, a biopharmaceutical company based in the United States, acquired Escient Pharmaceuticals for approximately $750 million. This acquisition is intended to bolster Incyte’s Inflammation and Autoimmunity (IAI) pipeline by incorporating Escient Pharmaceuticals’ first-in-class oral MRGPR antagonists, thereby enhancing its ability to develop novel therapies for serious immune and neuro-immune conditions. Escient Pharmaceuticals is a U.S.-based clinical-stage biotechnology company focused on developing EP262, a first-in-class oral MRGPRX2 antagonist aimed at treating mast cell-mediated diseases.

Major players in the mastocytosis drug market are Pfizer Inc., Johnson & Johnson, Bayer AG, Sanofi S.A., Novartis AG, GSK plc, Teva Pharmaceutical Industries Limited, Alcon Inc., Bausch Health Companies Inc., Genentech Inc., Lupin Limited, Blueprint Medicines Corporation, Don Valley Pharma (Pvt.) Ltd., Vivan Life Sciences Private Limited, AB Science S.A., Medoz Pharmaceutical Private Limited, Zumax Biocare Private Limited, Hi-Cure Biotech Private Limited, Zenomed Healthcare Private Limited, Biosynth AG.

North America was the largest region in the mastocytosis drug market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in mastocytosis drug report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the mastocytosis drug market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Mastocytosis drugs are medications used to treat mastocytosis, a rare disorder marked by the abnormal buildup of mast cells in the skin, bone marrow, and internal organs. These medications are designed to manage symptoms, suppress mast cell activity, or address more aggressive forms of the condition.

The primary types of mastocytosis drugs include antihistamines, corticosteroids, and mast cell stabilizers. Antihistamines serve as first-line treatments by alleviating symptoms through the prevention of histamine from binding to its receptors during allergic responses. These drugs are used to manage conditions such as systemic mastocytosis, cutaneous mastocytosis, and mast cell activation syndrome. They can be administered orally, intravenously, or subcutaneously. Distribution occurs through hospital pharmacies, online pharmacies, retail stores, and other channels. Key end users include hospitals, homecare settings, specialty clinics, and other healthcare facilities.

The mastocytosis drug market research report is one of a series of new reports that provides mastocytosis drug market statistics, including the mastocytosis drug industry global market size, regional shares, competitors with the mastocytosis drug market share, detailed mastocytosis drug market segments, market trends, and opportunities, and any further data you may need to thrive in the mastocytosis drug industry. This mastocytosis drug market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The mastocytosis drug market also includes sales of antihistamines, leukotriene receptor antagonists, corticosteroids, tyrosine kinase inhibitors (TKIs), and epinephrine. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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