Incretin-Based Drugs Global Market Report 2025

The incretin-based drugs market size has grown strongly in recent years. It will grow from $25.89 billion in 2024 to $27.83 billion in 2025 at a compound annual growth rate (CAGR) of 7.5%. The growth during the historic period can be attributed to the increasing global prevalence of type 2 diabetes, the launch of GLP-1 receptor agonists such as exenatide and liraglutide, substantial investments in research and development, favorable regulatory approvals for DPP-4 and GLP-1 medications, a transition from insulin and sulfonylureas to newer drug classes, and the introduction of once-weekly injectable formulations.

The incretin-based drugs market size is expected to see strong growth in the next few years. It will grow to $36.7 billion in 2029 at a compound annual growth rate (CAGR) of 7.2%. The growth expected in the forecast period can be attributed to the rising adoption of fixed-dose combination therapies, increased emphasis on weight management and diabetes associated with obesity, advancements in personalized medicine and companion diagnostics, growing demand for minimally invasive drug delivery methods, and an aging population with a higher burden of comorbidities. Key trends projected for the forecast period include the incorporation of incretin drugs into obesity treatment programs, the emergence of dual and triple agonists to improve metabolic outcomes, the integration of digital health tools with incretin therapies for personalized monitoring, the predominance of combination therapies over monotherapies for advanced diabetes management, and a growing focus on long-acting weekly injections to reduce dosing frequency.

The increasing prevalence of type 2 diabetes mellitus is expected to drive the growth of the incretin-based drugs market in the coming years. Type 2 diabetes mellitus is a chronic metabolic condition marked by insulin resistance and reduced insulin secretion, resulting in elevated blood glucose levels. This condition is primarily caused by factors such as poor diet and physical inactivity, which contribute to insulin resistance and impair the body’s ability to regulate blood sugar. Incretin-based drugs help manage type 2 diabetes by enhancing insulin secretion after meals and decreasing glucagon production, thereby lowering blood sugar levels. They also slow gastric emptying and suppress appetite, supporting better glucose control and weight reduction. For example, in June 2024, the National Health Service, a UK-based government organization, reported that in 2023 approximately 549,000 additional individuals in England were at risk of developing type 2 diabetes, increasing the total number of people with pre-diabetes to over 3.6 million - a rise of nearly 20% from 2022. Hence, the rising prevalence of type 2 diabetes mellitus is fueling the growth of the incretin-based drugs market.

Leading companies in the incretin-based drugs market are concentrating on developing generic drug versions to provide more effective and patient-friendly treatment options for type 2 diabetes. A generic drug contains the same active ingredients, strength, dosage form, and route of administration as its brand-name counterpart but is marketed under its chemical name without branding. For example, in December 2024, Hikma Pharmaceuticals PLC, a pharmaceutical company based in the UK, launched the first generic version of Victoza (liraglutide) injection, 6 mg/mL, in the United States. The drug received approval from the Food and Drug Administration (FDA) and is indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes, offering a more affordable treatment option amid ongoing shortages of GLP-1 medications.

In July 2024, Roche, a pharmaceutical company headquartered in Switzerland, acquired Carmot Therapeutics for approximately $2.7 billion. This strategic acquisition is aimed at enhancing Roche’s presence in the rapidly expanding obesity and metabolic disease market by incorporating Carmot’s innovative injectable and oral therapies into its pharmaceuticals division. Carmot Therapeutics is a U.S.-based clinical-stage biotechnology company specializing in obesity and diabetes, with a strong focus on incretin-based therapies, including GLP-1 and GIP receptor agonists.

Major players in the incretin-based drugs market are Pfizer Inc., Johnson & Johnson, Roche Holding AG, AbbVie Inc., Bristol-Myers Squibb Company, AstraZeneca PLC, Novartis AG, GlaxoSmithKline plc, Eli Lilly and Company, Takeda Pharmaceutical Company Limited, Amgen Inc., Novo Nordisk A/S, Viatris, Boehringer Ingelheim GmbH, Astellas Pharma Inc., Daiichi Sankyo Company Limited, Sun Pharmaceutical Industries Ltd., Sumitomo Dainippon Pharma Co. Ltd., Hikma Pharmaceuticals PLC, Lupin Limited, Mitsubishi Tanabe Pharma Corporation.

North America was the largest region in the incretin-based drugs market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in incretin-based drugs report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the incretin-based drugs market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Incretin-based drugs are medications used to manage type 2 diabetes by enhancing the effects of incretin hormones, which stimulate insulin release after meals. These drugs aid in controlling blood sugar levels, suppressing appetite, and supporting weight loss. They also help prevent sharp increases in blood glucose and generally have a low risk of causing severe hypoglycemia.

The primary types of incretin-based drugs include glucagon-like peptide-1 receptor (GLP-1) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors. GLP-1 receptor agonists imitate the natural GLP-1 hormone to boost insulin secretion, reduce glucagon levels, delay gastric emptying, and lower blood sugar in individuals with type 2 diabetes and obesity. These drugs are administered via different routes, such as oral and injectable forms, and are distributed through various channels, including hospital pharmacies, retail pharmacies, and online pharmacies, for applications such as type 2 diabetes, obesity, and other related conditions.

The incretin-based drugs market research report is one of a series of new reports that provides incretin-based drugs market statistics, including the incretin-based drugs industry global market size, regional shares, competitors with the incretin-based drugs market share, detailed incretin-based drugs market segments, market trends, opportunities, and any further data you may need to thrive in the incretin-based drugs industry. This incretin-based drugs market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The incretin-based drugs market consists of sales of dual or multi-agonists, glucagon receptor co-agonists, and fixed-dose combination drugs. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the drugs, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the drugs.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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