Protein A, G and L Resins - Global Strategic Business Report

The global market for Protein A, G and L Resins was estimated at US$792.0 Million in 2024 and is projected to reach US$875.0 Million by 2030, growing at a CAGR of 1.7% from 2024 to 2030. This comprehensive report provides an in-depth analysis of market trends, drivers, and forecasts, helping you make informed business decisions. The report includes the most recent global tariff developments and how they impact the Protein A, G and L Resins market.

Global Protein A, G, And L Resins Market - Key Trends & Drivers Summarized

Why Are Protein A, G, and L Resins Gaining Strategic Importance in Biopharmaceutical Purification?

Protein A, G, and L resins are critical affinity chromatography media used in the downstream purification of monoclonal antibodies (mAbs), recombinant proteins, and immunoglobulins. Their high selectivity for specific immunoglobulin (Ig) domains makes them essential in ensuring product purity, yield, and efficiency in bioprocessing workflows. Protein A resins, derived from Staphylococcus aureus, have become the industry standard for capturing IgG antibodies due to their strong binding affinity for the Fc region. Protein G and Protein L resins complement this capability by enabling purification of antibody fragments and Ig subtypes that Protein A does not efficiently bind.

As the biopharmaceutical industry expands its focus beyond mAbs to include bispecific antibodies, antibody fragments, and fusion proteins, the need for versatile and subtype-specific resins has intensified. Protein G resins bind a broader range of IgG subclasses across various species, while Protein L resins uniquely target kappa light chains, enabling purification of Fab fragments, scFv, and other light-chain-containing constructs. The diversity of these affinity ligands allows manufacturers to fine-tune purification strategies across preclinical, clinical, and commercial-scale production pipelines-enhancing throughput, compliance, and scalability.

Which End-Use Segments and Bioprocessing Applications Are Driving Adoption of Affinity Resins?

The primary end-user segment for Protein A, G, and L resins is the biopharmaceutical manufacturing industry, particularly in monoclonal antibody production for therapeutic and diagnostic applications. During large-scale manufacturing, Protein A chromatography serves as the first capture step in downstream processing, ensuring removal of process-related impurities and concentration of the target antibody. This step is foundational for achieving regulatory-grade purity and lot consistency. With mAbs constituting over 60% of current biologic drug approvals, the demand for Protein A resins continues to surge in both originator and biosimilar pipelines.

Protein G and L resins are increasingly utilized in research laboratories, contract development and manufacturing organizations (CDMOs), and diagnostic reagent companies. In particular, Protein G is valuable for purifying polyclonal IgG from animal models used in preclinical studies. Protein L resins, which lack Fc-binding properties, are used for isolating antibody fragments from bacterial or mammalian expression systems-especially in next-generation antibody therapies like CAR-T, nanobodies, and ADCs. These resins are also important for immunoprecipitation, immunoassay development, and analytical protein quantification in quality control labs.

How Are Resin Technologies, Binding Capacities, and Reusability Advancing Market Offerings?

Innovations in resin matrix materials, ligand engineering, and elution conditions are enhancing the performance of affinity resins across parameters such as dynamic binding capacity (DBC), chemical stability, and cycle life. Protein A ligands are being genetically modified or chemically engineered to reduce leaching, lower non-specific binding, and improve alkaline stability-enabling reuse across multiple purification cycles without significant loss in functionality. Manufacturers like Cytiva (MabSelect), Repligen (Natrix), Purolite, and Tosoh Bioscience are offering next-generation Protein A resins with DBC exceeding 50 mg/mL and caustic resistance suitable for 100+ cycles.

Disposable column formats and membrane-based affinity chromatography platforms are also gaining traction, particularly in single-use bioprocessing. These solutions reduce cleaning validation burdens, minimize cross-contamination, and support continuous manufacturing models. Additionally, Protein G and L resins are available in multiple bead sizes and formats (agarose, polymethacrylate, synthetic polymers), allowing compatibility with high-pressure liquid chromatography (HPLC) and fast protein liquid chromatography (FPLC) systems. Some formulations now integrate multi-modal ligands to improve selectivity for antibody-drug conjugates and complex fusion proteins, reflecting the shift toward tailored purification workflows.

What Factors Are Driving the Growth of the Global Protein A, G, and L Resins Market?

The growth in the global Protein A, G, and L resins market is driven by the increasing number of antibody-based therapeutics, rising demand for biosimilars, and expansion of CDMO capacities worldwide. As mAbs, antibody fragments, and novel biologics dominate the drug development pipeline, downstream purification has emerged as a bottleneck-placing pressure on manufacturers to adopt high-efficiency resins with minimal leaching and high throughput. Protein A resins remain irreplaceable in most IgG purification protocols, while Protein G and L address growing needs in research and advanced therapy platforms.

Further, the rise in personalized medicine and cell & gene therapy is boosting small-batch and flexible manufacturing formats, which benefit from scalable, reusable, and single-use resin solutions. Continuous bioprocessing, facilitated by high-capacity resins, is gaining favor for its operational efficiency and reduced footprint. Increasing regulatory scrutiny around product purity and resin extractables is pushing vendors to develop more robust and chemically inert matrices, supported by detailed validation data and GMP compliance.

Major market participants include Cytiva (Danaher), Thermo Fisher Scientific, Merck KGaA, Repligen, Purolite (Ecolab), Tosoh Corporation, Bio-Rad, and Takara Bio. These companies are investing in resin innovation, ligand development, and expanded manufacturing footprints to serve growing biologics hubs in Asia-Pacific, North America, and Europe. With continued biopharma investment in antibody modalities and purification optimization, the Protein A, G, and L resins market is positioned for sustained, high-value growth.

Scope Of Study:

The report analyzes the Protein A, G and L Resins market in terms of units by the following Segments, and Geographic Regions/Countries:

Segments: Type (Protein G Resin, Protein L Resin, Protein A Resin); Application (Pharmaceuticals Application, Research Labs Application, Other Applications)

Geographic Regions/Countries: World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; Spain; Russia; and Rest of Europe); Asia-Pacific (Australia; India; South Korea; and Rest of Asia-Pacific); Latin America (Argentina; Brazil; Mexico; and Rest of Latin America); Middle East (Iran; Israel; Saudi Arabia; United Arab Emirates; and Rest of Middle East); and Africa.

Key Insights:

• Market Growth: Understand the significant growth trajectory of the Protein G Resin segment, which is expected to reach US$490.2 Million by 2030 with a CAGR of a 1.9%. The Protein L Resin segment is also set to grow at 1.2% CAGR over the analysis period.
• Regional Analysis: Gain insights into the U.S. market, estimated at $215.8 Million in 2024, and China, forecasted to grow at an impressive 3.3% CAGR to reach $161.2 Million by 2030. Discover growth trends in other key regions, including Japan, Canada, Germany, and the Asia-Pacific.

Why You Should Buy This Report:

• Detailed Market Analysis: Access a thorough analysis of the Global Protein A, G and L Resins Market, covering all major geographic regions and market segments.
• Competitive Insights: Get an overview of the competitive landscape, including the market presence of major players across different geographies.
• Future Trends and Drivers: Understand the key trends and drivers shaping the future of the Global Protein A, G and L Resins Market.
• Actionable Insights: Benefit from actionable insights that can help you identify new revenue opportunities and make strategic business decisions.

Key Questions Answered:

• How is the Global Protein A, G and L Resins Market expected to evolve by 2030?
• What are the main drivers and restraints affecting the market?
• Which market segments will grow the most over the forecast period?
• How will market shares for different regions and segments change by 2030?
• Who are the leading players in the market, and what are their prospects?

Report Features:

• Comprehensive Market Data: Independent analysis of annual sales and market forecasts in US$ Million from 2024 to 2030.
• In-Depth Regional Analysis: Detailed insights into key markets, including the U.S., China, Japan, Canada, Europe, Asia-Pacific, Latin America, Middle East, and Africa.
• Company Profiles: Coverage of players such as Abcam plc, Agarose Bead Technologies, Agilent Technologies, Inc., Avantor, Inc., Bio-Rad Laboratories, Inc. and more.
• Complimentary Updates: Receive free report updates for one year to keep you informed of the latest market developments.

Some of the 36 companies featured in this Protein A, G and L Resins market report include:

• Abcam plc
• Agarose Bead Technologies
• Agilent Technologies, Inc.
• Avantor, Inc.
• Bio-Rad Laboratories, Inc.
• GE Healthcare (Cytiva)
• EMD Millipore (Merck KGaA)
• GenScript Biotech Corporation
• JSR Life Sciences Corporation
• Kaneka Corporation
• Novasep Holding SAS
• Pall Corporation (Danaher)
• PerkinElmer, Inc.
• Prometic Life Sciences Inc.
• Purolite Life Sciences (Ecolab)
• Repligen Corporation
• Sartorius Stedim Biotech S.A.
• Thermo Fisher Scientific Inc.
• Tosoh Bioscience LLC
• W. R. Grace & Co.

This edition integrates the latest global trade and economic shifts as of June 2025 into comprehensive market analysis. Key updates include:

• Tariff and Trade Impact: Insights into global tariff negotiations across 180+ countries, with analysis of supply chain turbulence, sourcing disruptions, and geographic realignment. Special focus on 2025 as a pivotal year for trade tensions, including updated perspectives on the Trump-era tariffs.
• Adjusted Forecasts and Analytics: Revised global and regional market forecasts through 2030, incorporating tariff effects, economic uncertainty, and structural changes in globalization. Includes segmentation by product, technology, type, material, distribution channel, application, and end-use, with historical analysis since 2015.
• Strategic Market Dynamics: Evaluation of revised market prospects, regional outlooks, and key economic indicators such as population and urbanization trends.
• Innovation & Technology Trends: Latest developments in product and process innovation, emerging technologies, and key industry drivers shaping the competitive landscape.
• Competitive Intelligence: Updated global market share estimates for 2025, competitive positioning of major players (Strong/Active/Niche/Trivial), and refined focus on leading global brands and core players.
• Expert Insight & Commentary: Strategic analysis from economists, trade experts, and domain specialists to contextualize market shifts and identify emerging opportunities.
• Complimentary Update: Buyers receive a free July 2025 update with finalized tariff impacts, new trade agreement effects, revised projections, and expanded country-level coverage.