Nanobodies - Global Strategic Business Report

The global market for Nanobodies was estimated at US$561.0 Million in 2024 and is projected to reach US$1.5 Billion by 2030, growing at a CAGR of 18.0% from 2024 to 2030. This comprehensive report provides an in-depth analysis of market trends, drivers, and forecasts, helping you make informed business decisions. The report includes the most recent global tariff developments and how they impact the Nanobodies market.

Global Nanobodies Market - Key Trends & Drivers Summarized

Why Are Nanobodies Gaining Momentum in Therapeutics and Diagnostics?

Nanobodies, also known as single-domain antibodies, are a unique class of antibody fragments derived from camelid species. Unlike conventional antibodies, nanobodies are small, stable, and can bind to hidden or difficult-to-reach epitopes. Their compact size allows better tissue penetration, rapid clearance from the bloodstream, and ease of manufacturing. These properties make them highly attractive for applications in oncology, autoimmune diseases, infectious disease treatment, and diagnostic imaging.

Their structural simplicity also enables rapid engineering into multi-specific formats or fusion proteins. Nanobodies can be delivered through non-traditional routes such as inhalation or topical application, offering alternatives to injectable biologics. With pharmaceutical developers increasingly seeking targeted, fast-acting, and cost-effective biologics, nanobodies are positioned as next-generation tools in both therapeutic development and in vivo diagnostics.

How Is Innovation in Design and Delivery Expanding Nanobody Potential?

Advances in protein engineering and phage display libraries are improving nanobody discovery and affinity optimization. Researchers can now generate synthetic nanobody libraries without direct reliance on camelid immunization, accelerating development timelines. Nanobodies are being designed for multivalent formats, which enhance binding strength or engage multiple targets simultaneously-especially relevant in cancer immunotherapy and viral neutralization.

In drug delivery, nanobodies are being fused with toxins, cytokines, or radionuclides to selectively target diseased cells. Their ability to be expressed in microbial systems like E. coli or yeast reduces production costs compared to full-length monoclonal antibodies. Nanobody-drug conjugates, nanobody-based CAR-T therapies, and bispecific formats are also under active development. These advances allow tailored delivery of therapeutic payloads while minimizing systemic exposure and immune-related toxicity.

Which Applications Are Driving Demand Across Research and Clinical Settings?

In diagnostics, nanobodies are widely used in biosensors, immunoassays, and molecular imaging tools. Their stability under extreme conditions makes them suitable for point-of-care testing and field-based detection systems. In imaging, nanobody-based PET tracers enable real-time visualization of tumors, inflammation, or infectious sites with higher resolution and faster clearance compared to conventional antibodies.

Therapeutically, nanobodies are being investigated for inflammatory conditions, cancers, neurodegenerative diseases, and viral infections including COVID-19. In oncology, nanobody-drug conjugates and immune checkpoint inhibitors are showing promise in early-phase clinical trials. In neurology, their ability to cross the blood-brain barrier is under evaluation for targeted delivery to amyloid plaques or misfolded proteins in diseases like Alzheimer's and Parkinson's. Veterinary medicine and agricultural biotechnology are also exploring nanobodies for disease control and detection.

Growth in the Nanobodies Market Is Driven by Several Factors

Growth in the nanobodies market is driven by several factors. Rising demand for targeted biologics and precision diagnostics encourages development of compact and high-affinity binding molecules. Advances in synthetic biology and display technologies accelerate nanobody discovery and screening. Cost-effective microbial expression systems support scalable production. Expanding clinical pipeline and regulatory support for biologics enhance commercial viability. Increased investment in oncology, neurodegeneration, and infectious disease research creates new application opportunities. Partnerships between biotech firms, academic labs, and pharmaceutical companies further support product development, licensing, and market expansion.

Scope Of Study:

The report analyzes the Nanobodies market in terms of units by the following Segments, and Geographic Regions/Countries:

Segments: Type (Mono-Specific Type, Multi-Specific Type); Application (Acquired Thrombotic Thrombocytopenic Purpura Application, Respiratory Syncytial Virus Infection Application, Rheumatoid Arthritis Application, Systemic Lupus Erythematosus Application, Oncology Application, Psoriasis Application, Bone Disorders Application, Other Applications); End-Use (Pharma & Biotech Companies End-Use, Research Laboratories End-Use, Other End-Uses)

Geographic Regions/Countries: World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; Spain; Russia; and Rest of Europe); Asia-Pacific (Australia; India; South Korea; and Rest of Asia-Pacific); Latin America (Argentina; Brazil; Mexico; and Rest of Latin America); Middle East (Iran; Israel; Saudi Arabia; United Arab Emirates; and Rest of Middle East); and Africa.

Key Insights:

• Market Growth: Understand the significant growth trajectory of the Mono-Specific Type segment, which is expected to reach US$1.1 Billion by 2030 with a CAGR of a 19.5%. The Multi-Specific Type segment is also set to grow at 14.8% CAGR over the analysis period.
• Regional Analysis: Gain insights into the U.S. market, estimated at $152.8 Million in 2024, and China, forecasted to grow at an impressive 24.0% CAGR to reach $342.4 Million by 2030. Discover growth trends in other key regions, including Japan, Canada, Germany, and the Asia-Pacific.

Why You Should Buy This Report:

• Detailed Market Analysis: Access a thorough analysis of the Global Nanobodies Market, covering all major geographic regions and market segments.
• Competitive Insights: Get an overview of the competitive landscape, including the market presence of major players across different geographies.
• Future Trends and Drivers: Understand the key trends and drivers shaping the future of the Global Nanobodies Market.
• Actionable Insights: Benefit from actionable insights that can help you identify new revenue opportunities and make strategic business decisions.

Key Questions Answered:

• How is the Global Nanobodies Market expected to evolve by 2030?
• What are the main drivers and restraints affecting the market?
• Which market segments will grow the most over the forecast period?
• How will market shares for different regions and segments change by 2030?
• Who are the leading players in the market, and what are their prospects?

Report Features:

• Comprehensive Market Data: Independent analysis of annual sales and market forecasts in US$ Million from 2024 to 2030.
• In-Depth Regional Analysis: Detailed insights into key markets, including the U.S., China, Japan, Canada, Europe, Asia-Pacific, Latin America, Middle East, and Africa.
• Company Profiles: Coverage of players such as AbCellera Biologics Inc., Abiocenter, Alpaca Nanobodies Inc., Amgen Inc., BIOCYTOGEN Group and more.
• Complimentary Updates: Receive free report updates for one year to keep you informed of the latest market developments.

Some of the 34 companies featured in this Nanobodies market report include:

• AbCellera Biologics Inc.
• Abiocenter
• Alpaca Nanobodies Inc.
• Amgen Inc.
• BIOCYTOGEN Group
• Bio-Rad Laboratories
• Boehringer Ingelheim GmbH
• Capralogics Inc.
• Creative Biolabs
• Cusabio
• GenScript Biotech Corporation
• Merck KGaA
• Morphosys AG (Ablynx tech)
• NanoTag Biotechnologies GmbH
• Novartis AG
• Proteintech Group, Inc.
• PREGENE
• QVQ Holding BV
• Sanofi (Ablynx)
• Thermo Fisher Scientific
• Yiteng Pharmaceutical

This edition integrates the latest global trade and economic shifts as of June 2025 into comprehensive market analysis. Key updates include:

• Tariff and Trade Impact: Insights into global tariff negotiations across 180+ countries, with analysis of supply chain turbulence, sourcing disruptions, and geographic realignment. Special focus on 2025 as a pivotal year for trade tensions, including updated perspectives on the Trump-era tariffs.
• Adjusted Forecasts and Analytics: Revised global and regional market forecasts through 2030, incorporating tariff effects, economic uncertainty, and structural changes in globalization. Includes segmentation by product, technology, type, material, distribution channel, application, and end-use, with historical analysis since 2015.
• Strategic Market Dynamics: Evaluation of revised market prospects, regional outlooks, and key economic indicators such as population and urbanization trends.
• Innovation & Technology Trends: Latest developments in product and process innovation, emerging technologies, and key industry drivers shaping the competitive landscape.
• Competitive Intelligence: Updated global market share estimates for 2025, competitive positioning of major players (Strong/Active/Niche/Trivial), and refined focus on leading global brands and core players.
• Expert Insight & Commentary: Strategic analysis from economists, trade experts, and domain specialists to contextualize market shifts and identify emerging opportunities.
• Complimentary Update: Buyers receive a free July 2025 update with finalized tariff impacts, new trade agreement effects, revised projections, and expanded country-level coverage.