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Poly ADP-Ribose Polymerase (PARP) Inhibitors - Global Strategic Business Report

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    Report

  • 284 Pages
  • July 2025
  • Region: Global
  • Global Industry Analysts, Inc
  • ID: 6106190
The global market for Poly ADP-Ribose Polymerase (PARP) Inhibitors was estimated at US$10.8 Billion in 2024 and is projected to reach US$34.9 Billion by 2030, growing at a CAGR of 21.7% from 2024 to 2030. This comprehensive report provides an in-depth analysis of market trends, drivers, and forecasts, helping you make informed business decisions. The report includes the most recent global tariff developments and how they impact the Poly ADP-Ribose Polymerase (PARP) Inhibitors market.

Global Poly ADP-Ribose Polymerase (PARP) Inhibitors Market - Key Trends & Drivers Summarized

Targeting DNA Repair Pathways: How PARP Inhibitors Are Reshaping Cancer Therapy Paradigms

Why Are PARP Inhibitors Revolutionizing Precision Oncology in Solid Tumor Management?

Poly ADP-ribose polymerase (PARP) inhibitors are a class of targeted cancer therapies that disrupt DNA repair mechanisms in cancer cells, leading to synthetic lethality in tumors with homologous recombination deficiencies (HRD). These oral agents selectively inhibit the PARP enzyme family-key players in repairing single-strand DNA breaks-thereby allowing lethal DNA damage to accumulate in cells lacking functional BRCA1/BRCA2 or other repair pathway proteins. The result is selective tumor cell death while sparing normal cells, offering a significant advancement in personalized medicine. Initially approved for BRCA-mutated ovarian cancer, PARP inhibitors have expanded into indications including breast, prostate, pancreatic, and endometrial cancers. Major approved agents include olaparib (Lynparza), niraparib (Zejula), rucaparib (Rubraca), and talazoparib (Talzenna), each with unique pharmacokinetics, toxicity profiles, and dosing protocols. These therapies have redefined treatment standards in both first-line and maintenance settings, particularly for patients with HRD-positive tumors. The therapeutic advantage of PARP inhibitors lies in their capacity to address genetically defined tumor subtypes that were previously underserved by conventional chemotherapy. Their oral administration and favorable toxicity profiles further enhance patient compliance, making them an attractive option in oncology portfolios.

Which Cancer Types and Patient Populations Are Driving the Adoption of PARP Inhibitors Globally?

Ovarian cancer remains the leading indication for PARP inhibitor therapy. In both frontline and recurrence settings, maintenance therapy with PARP inhibitors has significantly extended progression-free survival in patients with BRCA mutations or broader HRD signatures. Regulatory approvals have been expanded based on Phase III trials such as SOLO-1, PRIMA, and ARIEL3. These trials have validated the benefit of PARP inhibitors across BRCA-mutated and HRD-positive subgroups, broadening their clinical utility. In breast cancer, particularly triple-negative and HER2-negative tumors with germline BRCA mutations, PARP inhibitors have gained traction as monotherapy or combination therapy following chemotherapy. The OlympiAD and EMBRACA trials have provided robust evidence supporting their efficacy, leading to their integration into metastatic treatment pathways. In metastatic castration-resistant prostate cancer (mCRPC), agents like olaparib and rucaparib have been approved for patients with specific DNA damage repair (DDR) gene alterations, further expanding the clinical footprint of these agents. Pancreatic cancer, historically associated with poor prognosis and limited treatment options, has emerged as a new frontier for PARP inhibitors. The POLO trial demonstrated the utility of olaparib as a maintenance therapy for patients with BRCA-mutated tumors, representing a significant breakthrough in this notoriously aggressive malignancy. Additionally, real-world evidence and basket trials are exploring PARP efficacy in endometrial, bile duct, and small cell lung cancers where DNA repair defects are present.

How Are Clinical Strategies and Combination Therapies Enhancing PARP Inhibitor Utility?

The clinical strategy around PARP inhibitors is evolving rapidly with ongoing trials assessing their use in combination with immune checkpoint inhibitors (ICIs), anti-angiogenic agents, and chemotherapy. Preclinical data suggest that PARP inhibition increases tumor immunogenicity by activating cGAS-STING pathways, thereby enhancing the efficacy of PD-1/PD-L1 blockade. Trials like MEDIOLA and TOPACIO are evaluating this synergy in breast and ovarian cancers. Combination with VEGF inhibitors such as bevacizumab has shown promising outcomes, particularly in platinum-sensitive ovarian cancer. The PAOLA-1 trial demonstrated that olaparib plus bevacizumab extended PFS significantly in HRD-positive patients, supporting the use of PARP inhibitors beyond BRCA-mutated tumors. Additionally, studies are investigating sequencing strategies-using PARP inhibitors after platinum response or concurrently with taxane-based chemotherapy-to optimize clinical benefit. Biomarker development is also advancing. Beyond BRCA1/2, alterations in ATM, CHEK2, RAD51, and PALB2 are being validated as predictive markers of PARP sensitivity. HRD testing using genomic instability scores is being integrated into clinical workflows to identify eligible patients more accurately. Companion diagnostics are co-evolving with therapy approvals, aligning drug deployment with molecular testing infrastructure.

What Market Drivers Are Propelling the Global Growth of PARP Inhibitors?

The growth in the PARP inhibitors market is driven by multiple intersecting forces including precision oncology expansion, biomarker-based patient stratification, and increasing prevalence of BRCA-tested patients. One of the foremost drivers is the paradigm shift toward personalized cancer therapy. As next-generation sequencing (NGS) becomes standard practice in oncology, more patients are being identified with HRD-related mutations, expanding the addressable market for PARP inhibitors. The demand for maintenance therapies with minimal toxicity is accelerating uptake in frontline settings, particularly in ovarian and prostate cancers. Additionally, growing payer support for companion diagnostics and biomarker-guided prescribing is reducing reimbursement hurdles, enabling broader adoption across community oncology practices and emerging healthcare systems.

Regulatory support is also robust, with breakthrough therapy designations, fast-track approvals, and international regulatory harmonization accelerating market entry. Emerging economies in Asia-Pacific and Latin America are incorporating PARP inhibitors into national cancer control strategies, driven by rising awareness of BRCA testing and inclusion in treatment guidelines. As combination regimens, earlier-line indications, and pan-cancer biomarker approvals progress through pipelines, the commercial outlook for PARP inhibitors is poised for sustained growth. Their expanding clinical versatility, oral delivery format, and synergy with other targeted agents make them central to the future of oncology therapeutics.

Scope Of Study:

The report analyzes the Poly ADP-Ribose Polymerase (PARP) Inhibitors market in terms of units by the following Segments, and Geographic Regions/Countries:

Segments: Distribution Channel (Retail Pharmacies, Hospital Pharmacies, Online Distribution Channel); End-Use (Ovarian Cancer End-Use, Breast Cancer End-Use, Other End-Uses)

Geographic Regions/Countries: World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; Spain; Russia; and Rest of Europe); Asia-Pacific (Australia; India; South Korea; and Rest of Asia-Pacific); Latin America (Argentina; Brazil; Mexico; and Rest of Latin America); Middle East (Iran; Israel; Saudi Arabia; United Arab Emirates; and Rest of Middle East); and Africa.

Key Insights:

  • Market Growth: Understand the significant growth trajectory of the Retail Pharmacies segment, which is expected to reach US$23.3 Billion by 2030 with a CAGR of a 23.1%. The Hospital Pharmacies segment is also set to grow at 19.6% CAGR over the analysis period.
  • Regional Analysis: Gain insights into the U.S. market, estimated at $2.9 Billion in 2024, and China, forecasted to grow at an impressive 29.2% CAGR to reach $8.4 Billion by 2030. Discover growth trends in other key regions, including Japan, Canada, Germany, and the Asia-Pacific.

Why You Should Buy This Report:

  • Detailed Market Analysis: Access a thorough analysis of the Global Poly ADP-Ribose Polymerase (PARP) Inhibitors Market, covering all major geographic regions and market segments.
  • Competitive Insights: Get an overview of the competitive landscape, including the market presence of major players across different geographies.
  • Future Trends and Drivers: Understand the key trends and drivers shaping the future of the Global Poly ADP-Ribose Polymerase (PARP) Inhibitors Market.
  • Actionable Insights: Benefit from actionable insights that can help you identify new revenue opportunities and make strategic business decisions.

Key Questions Answered:

  • How is the Global Poly ADP-Ribose Polymerase (PARP) Inhibitors Market expected to evolve by 2030?
  • What are the main drivers and restraints affecting the market?
  • Which market segments will grow the most over the forecast period?
  • How will market shares for different regions and segments change by 2030?
  • Who are the leading players in the market, and what are their prospects?

Report Features:

  • Comprehensive Market Data: Independent analysis of annual sales and market forecasts in US$ Million from 2024 to 2030.
  • In-Depth Regional Analysis: Detailed insights into key markets, including the U.S., China, Japan, Canada, Europe, Asia-Pacific, Latin America, Middle East, and Africa.
  • Company Profiles: Coverage of players such as AbbVie Inc., Allarity Therapeutics Inc., Artios Pharma, AstraZeneca Plc, Bayer AG and more.
  • Complimentary Updates: Receive free report updates for one year to keep you informed of the latest market developments.

Some of the 47 companies featured in this Poly ADP-Ribose Polymerase (PARP) Inhibitors market report include:

  • AbbVie Inc.
  • Allarity Therapeutics Inc.
  • Artios Pharma
  • AstraZeneca Plc
  • Bayer AG
  • BeiGene Ltd.
  • Clovis Oncology (now part of Bristol Myers Squibb)
  • Daiichi Sankyo Co. Ltd.
  • Everest Pharmaceuticals Ltd.
  • GlaxoSmithKline Plc
  • IMPACT Therapeutics
  • Jeil Pharmaceuticals Co. Ltd.
  • Jiangsu Hengrui Pharmaceuticals Co. Ltd.
  • Johnson & Johnson Services, Inc.
  • Karyopharm Therapeutics Inc.
  • Merck & Co., Inc.
  • Ono Pharmaceutical Co. Ltd.
  • Pfizer Inc.
  • Repare Therapeutics Inc.
  • Zai Lab Ltd.

This edition integrates the latest global trade and economic shifts as of June 2025 into comprehensive market analysis. Key updates include:

  • Tariff and Trade Impact: Insights into global tariff negotiations across 180+ countries, with analysis of supply chain turbulence, sourcing disruptions, and geographic realignment. Special focus on 2025 as a pivotal year for trade tensions, including updated perspectives on the Trump-era tariffs.
  • Adjusted Forecasts and Analytics: Revised global and regional market forecasts through 2030, incorporating tariff effects, economic uncertainty, and structural changes in globalization. Includes segmentation by product, technology, type, material, distribution channel, application, and end-use, with historical analysis since 2015.
  • Strategic Market Dynamics: Evaluation of revised market prospects, regional outlooks, and key economic indicators such as population and urbanization trends.
  • Innovation & Technology Trends: Latest developments in product and process innovation, emerging technologies, and key industry drivers shaping the competitive landscape.
  • Competitive Intelligence: Updated global market share estimates for 2025, competitive positioning of major players (Strong/Active/Niche/Trivial), and refined focus on leading global brands and core players.
  • Expert Insight & Commentary: Strategic analysis from economists, trade experts, and domain specialists to contextualize market shifts and identify emerging opportunities.
  • Complimentary Update: Buyers receive a free July 2025 update with finalized tariff impacts, new trade agreement effects, revised projections, and expanded country-level coverage.

Table of Contents

I. METHODOLOGYII. EXECUTIVE SUMMARY
1. MARKET OVERVIEW
  • Influencer Market Insights
  • World Market Trajectories
  • Tariff Impact on Global Supply Chain Patterns
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors - Global Key Competitors Percentage Market Share in 2025 (E)
  • Competitive Market Presence - Strong/Active/Niche/Trivial for Players Worldwide in 2025 (E)
2. FOCUS ON SELECT PLAYERS
3. MARKET TRENDS & DRIVERS
  • Rising Incidence of Ovarian and Breast Cancers Expands Addressable Market for PARP Inhibitors
  • Growing Use of PARP Inhibitors in Precision Oncology Strengthens Business Case for Targeted Therapies
  • FDA and EMA Approvals of New Indications Propel Commercial Uptake Across Oncology Segments
  • Expansion of Companion Diagnostics Throws the Spotlight on Biomarker-Driven Treatment Protocols
  • Ongoing Clinical Trials in Prostate and Pancreatic Cancers Drive Indication Pipeline Diversification
  • Integration With Immuno-Oncology and Combination Therapies Enhances Treatment Efficacy
  • Rising Healthcare Spending in Emerging Markets Accelerates Global Access to PARP Inhibitors
  • Strategic Collaborations Between Pharma and Diagnostic Companies Fuel Development Synergies
  • Growth in Germline and Somatic Mutation Testing Supports Patient Stratification and Adoption
  • Patent Expiries and Generic Entry Pose Pricing Pressure and Market Disruption Risks
  • Increasing Reimbursement Approvals Across Oncology Centers Sustain Treatment Adoption
  • Technological Advancements in Drug Delivery Systems Improve Bioavailability and Patient Compliance
  • Focus on Long-Term Survival and Maintenance Therapies Drives Repeat Treatment Cycles
  • Regulatory Fast-Tracking of Breakthrough Therapies Enhances Speed-to-Market for New Entrants
  • Rise in Awareness Programs for BRCA-Mutated Cancers Strengthens Patient Outreach Efforts
  • Investments in Real-World Evidence and Outcome Studies Bolster Market Positioning
  • Expansion of Hospital-Based Oncology Infrastructure Promotes Institutional Procurement
  • Integration Into National Cancer Control Programs Facilitates Widespread Adoption
  • Pharmacovigilance and Post-Marketing Surveillance Requirements Create Compliance Complexity
  • Emerging Applications in Rare and Orphan Oncology Indications Unlock Niche Market Potential
4. GLOBAL MARKET PERSPECTIVE
  • TABLE 1: World Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Analysis of Annual Sales in US$ Million for Years 2014 through 2030
  • TABLE 2: World Recent Past, Current & Future Analysis for Poly ADP-Ribose Polymerase (PARP) Inhibitors by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 3: World Historic Review for Poly ADP-Ribose Polymerase (PARP) Inhibitors by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2023 and % CAGR
  • TABLE 4: World 16-Year Perspective for Poly ADP-Ribose Polymerase (PARP) Inhibitors by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets for Years 2014, 2025 & 2030
  • TABLE 5: World Recent Past, Current & Future Analysis for Retail Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 6: World Historic Review for Retail Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2023 and % CAGR
  • TABLE 7: World 16-Year Perspective for Retail Pharmacies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2025 & 2030
  • TABLE 8: World Recent Past, Current & Future Analysis for Hospital Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 9: World Historic Review for Hospital Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2023 and % CAGR
  • TABLE 10: World 16-Year Perspective for Hospital Pharmacies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2025 & 2030
  • TABLE 11: World Recent Past, Current & Future Analysis for Online Distribution Channel by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 12: World Historic Review for Online Distribution Channel by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2023 and % CAGR
  • TABLE 13: World 16-Year Perspective for Online Distribution Channel by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2025 & 2030
  • TABLE 14: World Recent Past, Current & Future Analysis for Ovarian Cancer End-Use by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 15: World Historic Review for Ovarian Cancer End-Use by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2023 and % CAGR
  • TABLE 16: World 16-Year Perspective for Ovarian Cancer End-Use by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2025 & 2030
  • TABLE 17: World Recent Past, Current & Future Analysis for Breast Cancer End-Use by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 18: World Historic Review for Breast Cancer End-Use by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2023 and % CAGR
  • TABLE 19: World 16-Year Perspective for Breast Cancer End-Use by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2025 & 2030
  • TABLE 20: World Recent Past, Current & Future Analysis for Other End-Uses by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2024 through 2030 and % CAGR
  • TABLE 21: World Historic Review for Other End-Uses by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2023 and % CAGR
  • TABLE 22: World 16-Year Perspective for Other End-Uses by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2025 & 2030
III. MARKET ANALYSIS
UNITED STATES
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in the United States for 2025 (E)
CANADA
JAPAN
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Japan for 2025 (E)
CHINA
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in China for 2025 (E)
EUROPE
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Europe for 2025 (E)
FRANCE
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in France for 2025 (E)
GERMANY
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Germany for 2025 (E)
ITALY
UNITED KINGDOM
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in the United Kingdom for 2025 (E)
SPAINRUSSIAREST OF EUROPE
ASIA-PACIFIC
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Asia-Pacific for 2025 (E)
AUSTRALIA
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Australia for 2025 (E)
INDIA
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in India for 2025 (E)
SOUTH KOREAREST OF ASIA-PACIFIC
LATIN AMERICA
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Latin America for 2025 (E)
ARGENTINABRAZILMEXICOREST OF LATIN AMERICA
MIDDLE EAST
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Middle East for 2025 (E)
IRANISRAELSAUDI ARABIAUNITED ARAB EMIRATESREST OF MIDDLE EAST
AFRICA
  • Poly ADP-Ribose Polymerase (PARP) Inhibitors Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Africa for 2025 (E)
IV. COMPETITION

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • AbbVie Inc.
  • Allarity Therapeutics Inc.
  • Artios Pharma
  • AstraZeneca Plc
  • Bayer AG
  • BeiGene Ltd.
  • Clovis Oncology (now part of Bristol Myers Squibb)
  • Daiichi Sankyo Co. Ltd.
  • Everest Pharmaceuticals Ltd.
  • GlaxoSmithKline Plc
  • IMPACT Therapeutics
  • Jeil Pharmaceuticals Co. Ltd.
  • Jiangsu Hengrui Pharmaceuticals Co. Ltd.
  • Johnson & Johnson Services, Inc.
  • Karyopharm Therapeutics Inc.
  • Merck & Co., Inc.
  • Ono Pharmaceutical Co. Ltd.
  • Pfizer Inc.
  • Repare Therapeutics Inc.
  • Zai Lab Ltd.

Table Information