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HLA Typing Global Market Insights 2025, Analysis and Forecast to 2030, by Market Participants, Regions, Technology, Application, Product Type

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    Report

  • 114 Pages
  • July 2025
  • Region: Global
  • Prof Research
  • ID: 6114232
Description Jump to:
HLA (Human Leukocyte Antigen) typing represents a critical diagnostic technology in modern medicine, encompassing sophisticated molecular techniques designed to identify genetic compatibility for organ transplantation, stem cell therapy, and personalized medicine applications. These systems utilize advanced methodologies including polymerase chain reaction (PCR) with sequence-specific oligonucleotides (SSO), sequence-specific primers (SSP), real-time PCR, and next-generation sequencing (NGS) technologies, alongside traditional Sanger sequencing approaches. The technology is extensively deployed across hospitals, reference laboratories, transplant centers, and research institutions globally. The market is fundamentally driven by the increasing demand for organ transplantation procedures, with approximately 140,000 organ transplants performed annually worldwide, alongside the growing prevalence of autoimmune diseases, cancer immunotherapy applications, and the expanding adoption of personalized medicine approaches. The rising incidence of chronic diseases requiring transplantation, particularly kidney, liver, and heart conditions, combined with advancements in genomic medicine and precision healthcare, continues to fuel market expansion.

Market Size and Growth Forecast

The global HLA typing market is projected to reach between USD 1.0 billion and USD 2.0 billion in 2025, with a compound annual growth rate (CAGR) of 5% to 10% through 2030, reflecting the increasing integration of molecular diagnostics in transplant medicine and the growing emphasis on personalized therapeutic approaches.

Regional Analysis

  • North America: The United States dominates the market with advanced transplant programs and comprehensive HLA testing infrastructure, while Canada focuses on expanding access to transplant services and improving donor-recipient matching protocols.
  • Europe: Germany, France, and the United Kingdom lead the region, driven by established transplant networks, stringent regulatory frameworks for organ allocation, and significant investments in genomic medicine research and clinical applications.
  • Asia Pacific: China and India demonstrate rapid growth due to expanding healthcare infrastructure and increasing transplant volumes, while Japan emphasizes precision medicine integration and advanced sequencing technologies for improved patient outcomes.
  • Rest of the World: Brazil enhances transplant capabilities through improved HLA testing infrastructure, while the Middle East, particularly the UAE and Saudi Arabia, invests in cutting-edge genomic technologies and specialized transplant centers.

Application Analysis

  • Hospitals: Expected growth of 6.0-10.5%, driven by increasing transplant procedures and expanding clinical applications. Trends focus on automation, rapid turnaround times, and integration with electronic health records for improved patient management.
  • Reference Labs: Projected growth of 5.5-9.8%, linked to centralized testing services and specialized expertise. Developments emphasize high-throughput capabilities, comprehensive allele coverage, and advanced bioinformatics platforms for accurate interpretation.

Type Analysis

  • PCR-Based Methods (SSO, SSP, Real-time): Expected growth of 4.5-8.5%, valued for rapid results and cost-effectiveness in routine applications. Trends focus on automation, multiplexing capabilities, and improved resolution for better donor-recipient matching.
  • Sequencing Technologies (NGS, Sanger's): Projected growth of 7.0-12.0%, key for high-resolution typing and comprehensive allele identification. Advances highlight next-generation sequencing adoption, bioinformatics integration, and reduced per-sample costs through improved efficiency.

Key Market Players

Leading firms include BD, providing comprehensive molecular diagnostic solutions; Thermo Fisher Scientific, offering advanced sequencing platforms and reagents; Bio-Rad Laboratories, specializing in PCR-based typing systems; Roche, innovating in molecular diagnostics and automation; Illumina, leading NGS technology development; Immucor, focusing on transplant diagnostics; CareDx, advancing transplant monitoring solutions; Creative Biolabs, supporting research applications; Fujirebio Holdings, providing specialized testing platforms; GenDx, offering high-resolution typing solutions; Hologic, integrating molecular diagnostics; Histogenetics, specializing in transplant services; PacBio, advancing long-read sequencing; Proimmune, focusing on immune monitoring; Omixon, providing NGS-based solutions; Inno-Train Diagnostik, offering specialized reagents; Krishgen Biosystems, supporting Asian markets; Takara Bio, providing molecular biology tools; and TBG Diagnostics, focusing on transplant applications. These companies drive market growth through technological innovations, automation advances, and improved clinical outcomes.

Porter's Five Forces Analysis

  • Threat of New Entrants: Moderate, due to high regulatory requirements, significant R&D investments, and established relationships with transplant centers, though niche players can enter with innovative sequencing approaches or specialized applications.
  • Threat of Substitutes: Low, as HLA typing remains essential for transplant success with no viable alternatives, though emerging technologies like artificial intelligence and machine learning may enhance existing methods.
  • Bargaining Power of Buyers: Moderate, with hospitals and laboratories seeking cost-effective, accurate systems while maintaining regulatory compliance and clinical quality standards for patient safety.
  • Bargaining Power of Suppliers: Low, due to multiple reagent suppliers, equipment manufacturers, and technology providers, reducing dependency risks and enabling competitive pricing strategies.
  • Competitive Rivalry: High, with firms competing on accuracy, turnaround time, automation capabilities, comprehensive allele coverage, and cost-effectiveness while maintaining regulatory compliance.

Market Opportunities and Challenges

Opportunities: The growing global organ shortage, with over 100,000 Americans on transplant waiting lists, drives demand for improved HLA matching technologies to maximize transplant success rates. The expanding applications in cancer immunotherapy, particularly CAR-T cell therapy and checkpoint inhibitors, create new market segments requiring specialized HLA typing services. Advancements in NGS technologies, including portable sequencing platforms and real-time analysis capabilities, enhance accessibility and reduce costs. The integration of artificial intelligence and machine learning algorithms improves allele calling accuracy and reduces interpretation errors. Emerging markets present significant growth opportunities as healthcare infrastructure develops and transplant programs expand.

Challenges: High costs of advanced sequencing equipment and ongoing reagent expenses limit adoption in resource-constrained healthcare systems. Complex regulatory landscapes across different regions create compliance challenges for manufacturers and service providers. The shortage of skilled personnel capable of performing and interpreting HLA typing results constrains market growth. Technical challenges in resolving ambiguous typing results and standardizing interpretation protocols across different platforms require ongoing attention. Limited awareness and training in developing markets slow technology adoption and market penetration.

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Table of Contents

Chapter 1 Executive SummaryChapter 2 Abbreviation and Acronyms
Chapter 3 Preface
3.1 Research Scope
3.2 Research Sources
3.2.1 Data Sources
3.2.2 Assumptions
3.3 Research Method
Chapter 4 Market Landscape
4.1 Market Overview
4.2 Classification/Types
4.3 Application/End Users
Chapter 5 Market Trend Analysis
5.1 Introduction
5.2 Drivers
5.3 Restraints
5.4 Opportunities
5.5 Threats
Chapter 6 Industry Chain Analysis
6.1 Upstream/Suppliers Analysis
6.2 Hla Typing Analysis
6.2.1 Technology Analysis
6.2.2 Cost Analysis
6.2.3 Market Channel Analysis
6.3 Downstream Buyers/End Users
Chapter 7 Latest Market Dynamics
7.1 Latest News
7.2 Merger and Acquisition
7.3 Planned/Future Project
7.4 Policy Dynamics
Chapter 8 Historical and Forecast Hla Typing Market in North America (2020-2030)
8.1 Hla Typing Market Size
8.2 Hla Typing Market by End Use
8.3 Competition by Players/Suppliers
8.4 Hla Typing Market Size by Type
8.5 Key Countries Analysis
8.5.1 United States
8.5.2 Canada
8.5.3 Mexico
Chapter 9 Historical and Forecast Hla Typing Market in South America (2020-2030)
9.1 Hla Typing Market Size
9.2 Hla Typing Market by End Use
9.3 Competition by Players/Suppliers
9.4 Hla Typing Market Size by Type
9.5 Key Countries Analysis
9.5.1 Brazil
9.5.2 Argentina
9.5.3 Chile
9.5.4 Peru
Chapter 10 Historical and Forecast Hla Typing Market in Asia & Pacific (2020-2030)
10.1 Hla Typing Market Size
10.2 Hla Typing Market by End Use
10.3 Competition by Players/Suppliers
10.4 Hla Typing Market Size by Type
10.5 Key Countries Analysis
10.5.1 China
10.5.2 India
10.5.3 Japan
10.5.4 South Korea
10.5.5 Southeast Asia
10.5.6 Australia
Chapter 11 Historical and Forecast Hla Typing Market in Europe (2020-2030)
11.1 Hla Typing Market Size
11.2 Hla Typing Market by End Use
11.3 Competition by Players/Suppliers
11.4 Hla Typing Market Size by Type
11.5 Key Countries Analysis
11.5.1 Germany
11.5.2 France
11.5.3 United Kingdom
11.5.4 Italy
11.5.5 Spain
11.5.6 Belgium
11.5.7 Netherlands
11.5.8 Austria
11.5.9 Poland
11.5.10 Russia
Chapter 12 Historical and Forecast Hla Typing Market in MEA (2020-2030)
12.1 Hla Typing Market Size
12.2 Hla Typing Market by End Use
12.3 Competition by Players/Suppliers
12.4 Hla Typing Market Size by Type
12.5 Key Countries Analysis
12.5.1 Egypt
12.5.2 Israel
12.5.3 South Africa
12.5.4 Gulf Cooperation Council Countries
12.5.5 Turkey
Chapter 13 Summary For Global Hla Typing Market (2020-2025)
13.1 Hla Typing Market Size
13.2 Hla Typing Market by End Use
13.3 Competition by Players/Suppliers
13.4 Hla Typing Market Size by Type
Chapter 14 Global Hla Typing Market Forecast (2025-2030)
14.1 Hla Typing Market Size Forecast
14.2 Hla Typing Application Forecast
14.3 Competition by Players/Suppliers
14.4 Hla Typing Type Forecast
Chapter 15 Analysis of Global Key Vendors
15.1 BD
15.1.1 Company Profile
15.1.2 Main Business and HLA Typing Information
15.1.3 SWOT Analysis of BD
15.1.4 BD HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.2 Thermo Fisher Scientific
15.2.1 Company Profile
15.2.2 Main Business and HLA Typing Information
15.2.3 SWOT Analysis of Thermo Fisher Scientific
15.2.4 Thermo Fisher Scientific HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.3 Bio-Rad Laboratories
15.3.1 Company Profile
15.3.2 Main Business and HLA Typing Information
15.3.3 SWOT Analysis of Bio-Rad Laboratories
15.3.4 Bio-Rad Laboratories HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.4 Bruker
15.4.1 Company Profile
15.4.2 Main Business and HLA Typing Information
15.4.3 SWOT Analysis of Bruker
15.4.4 Bruker HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.5 F. Hoffman-La Roche
15.5.1 Company Profile
15.5.2 Main Business and HLA Typing Information
15.5.3 SWOT Analysis of F. Hoffman-La Roche
15.5.4 F. Hoffman-La Roche HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.6 Bag Diagnostics
15.6.1 Company Profile
15.6.2 Main Business and HLA Typing Information
15.6.3 SWOT Analysis of Bag Diagnostics
15.6.4 Bag Diagnostics HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.7 Caredx
15.7.1 Company Profile
15.7.2 Main Business and HLA Typing Information
15.7.3 SWOT Analysis of Caredx
15.7.4 Caredx HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.8 Creative Biolabs
15.8.1 Company Profile
15.8.2 Main Business and HLA Typing Information
15.8.3 SWOT Analysis of Creative Biolabs
15.8.4 Creative Biolabs HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.9 Fujirebio Holdings
15.9.1 Company Profile
15.9.2 Main Business and HLA Typing Information
15.9.3 SWOT Analysis of Fujirebio Holdings
15.9.4 Fujirebio Holdings HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.10 Gendx
15.10.1 Company Profile
15.10.2 Main Business and HLA Typing Information
15.10.3 SWOT Analysis of Gendx
15.10.4 Gendx HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.11 Hologic
15.11.1 Company Profile
15.11.2 Main Business and HLA Typing Information
15.11.3 SWOT Analysis of Hologic
15.11.4 Hologic HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.12 Histogenetics
15.12.1 Company Profile
15.12.2 Main Business and HLA Typing Information
15.12.3 SWOT Analysis of Histogenetics
15.12.4 Histogenetics HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.13 Hansa Biopharma
15.13.1 Company Profile
15.13.2 Main Business and HLA Typing Information
15.13.3 SWOT Analysis of Hansa Biopharma
15.13.4 Hansa Biopharma HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.14 lllumina
15.14.1 Company Profile
15.14.2 Main Business and HLA Typing Information
15.14.3 SWOT Analysis of lllumina
15.14.4 lllumina HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.15 Inno-Train Diagnostik GmbH
15.15.1 Company Profile
15.15.2 Main Business and HLA Typing Information
15.15.3 SWOT Analysis of Inno-Train Diagnostik GmbH
15.15.4 Inno-Train Diagnostik GmbH HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.16 Immucor
15.16.1 Company Profile
15.16.2 Main Business and HLA Typing Information
15.16.3 SWOT Analysis of Immucor
15.16.4 Immucor HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.17 Krishgen Biosystems
15.17.1 Company Profile
15.17.2 Main Business and HLA Typing Information
15.17.3 SWOT Analysis of Krishgen Biosystems
15.17.4 Krishgen Biosystems HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.18 Omixon
15.18.1 Company Profile
15.18.2 Main Business and HLA Typing Information
15.18.3 SWOT Analysis of Omixon
15.18.4 Omixon HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.19 PacBio
15.19.1 Company Profile
15.19.2 Main Business and HLA Typing Information
15.19.3 SWOT Analysis of PacBio
15.19.4 PacBio HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.20 Proimmune
15.20.1 Company Profile
15.20.2 Main Business and HLA Typing Information
15.20.3 SWOT Analysis of Proimmune
15.20.4 Proimmune HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.21 TBG Diagnostics Limited
15.21.1 Company Profile
15.21.2 Main Business and HLA Typing Information
15.21.3 SWOT Analysis of TBG Diagnostics Limited
15.21.4 TBG Diagnostics Limited HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
15.22 Takara Bio
15.22.1 Company Profile
15.22.2 Main Business and HLA Typing Information
15.22.3 SWOT Analysis of Takara Bio
15.22.4 Takara Bio HLA Typing Revenue, Gross Margin and Market Share (2020-2025)
Tables and Figures
Table Abbreviation and Acronyms
Table Research Scope of Hla Typing Report
Table Data Sources of Hla Typing Report
Table Major Assumptions of Hla Typing Report
Figure Market Size Estimated Method
Figure Major Forecasting Factors
Figure Hla Typing Picture
Table Hla Typing Classification
Table Hla Typing Applications
Table Drivers of Hla Typing Market
Table Restraints of Hla Typing Market
Table Opportunities of Hla Typing Market
Table Threats of Hla Typing Market
Table COVID-19 Impact For Hla Typing Market
Table Raw Materials Suppliers
Table Different Production Methods of Hla Typing
Table Cost Structure Analysis of Hla Typing
Table Key End Users
Table Latest News of Hla Typing Market
Table Merger and Acquisition
Table Planned/Future Project of Hla Typing Market
Table Policy of Hla Typing Market
Table 2020-2030 North America Hla Typing Market Size
Figure 2020-2030 North America Hla Typing Market Size and CAGR
Table 2020-2030 North America Hla Typing Market Size by Application
Table 2020-2025 North America Hla Typing Key Players Revenue
Table 2020-2025 North America Hla Typing Key Players Market Share
Table 2020-2030 North America Hla Typing Market Size by Type
Table 2020-2030 United States Hla Typing Market Size
Table 2020-2030 Canada Hla Typing Market Size
Table 2020-2030 Mexico Hla Typing Market Size
Table 2020-2030 South America Hla Typing Market Size
Figure 2020-2030 South America Hla Typing Market Size and CAGR
Table 2020-2030 South America Hla Typing Market Size by Application
Table 2020-2025 South America Hla Typing Key Players Revenue
Table 2020-2025 South America Hla Typing Key Players Market Share
Table 2020-2030 South America Hla Typing Market Size by Type
Table 2020-2030 Brazil Hla Typing Market Size
Table 2020-2030 Argentina Hla Typing Market Size
Table 2020-2030 Chile Hla Typing Market Size
Table 2020-2030 Peru Hla Typing Market Size
Table 2020-2030 Asia & Pacific Hla Typing Market Size
Figure 2020-2030 Asia & Pacific Hla Typing Market Size and CAGR
Table 2020-2030 Asia & Pacific Hla Typing Market Size by Application
Table 2020-2025 Asia & Pacific Hla Typing Key Players Revenue
Table 2020-2025 Asia & Pacific Hla Typing Key Players Market Share
Table 2020-2030 Asia & Pacific Hla Typing Market Size by Type
Table 2020-2030 China Hla Typing Market Size
Table 2020-2030 India Hla Typing Market Size
Table 2020-2030 Japan Hla Typing Market Size
Table 2020-2030 South Korea Hla Typing Market Size
Table 2020-2030 Southeast Asia Hla Typing Market Size
Table 2020-2030 Australia Hla Typing Market Size
Table 2020-2030 Europe Hla Typing Market Size
Figure 2020-2030 Europe Hla Typing Market Size and CAGR
Table 2020-2030 Europe Hla Typing Market Size by Application
Table 2020-2025 Europe Hla Typing Key Players Revenue
Table 2020-2025 Europe Hla Typing Key Players Market Share
Table 2020-2030 Europe Hla Typing Market Size by Type
Table 2020-2030 Germany Hla Typing Market Size
Table 2020-2030 France Hla Typing Market Size
Table 2020-2030 United Kingdom Hla Typing Market Size
Table 2020-2030 Italy Hla Typing Market Size
Table 2020-2030 Spain Hla Typing Market Size
Table 2020-2030 Belgium Hla Typing Market Size
Table 2020-2030 Netherlands Hla Typing Market Size
Table 2020-2030 Austria Hla Typing Market Size
Table 2020-2030 Poland Hla Typing Market Size
Table 2020-2030 Russia Hla Typing Market Size
Table 2020-2030 MEA Hla Typing Market Size
Figure 2020-2030 MEA Hla Typing Market Size and CAGR
Table 2020-2030 MEA Hla Typing Market Size by Application
Table 2020-2025 MEA Hla Typing Key Players Revenue
Table 2020-2025 MEA Hla Typing Key Players Market Share
Table 2020-2030 MEA Hla Typing Market Size by Type
Table 2020-2030 Egypt Hla Typing Market Size
Table 2020-2030 Israel Hla Typing Market Size
Table 2020-2030 South Africa Hla Typing Market Size
Table 2020-2030 Gulf Cooperation Council Countries Hla Typing Market Size
Table 2020-2030 Turkey Hla Typing Market Size
Table 2020-2025 Global Hla Typing Market Size by Region
Table 2020-2025 Global Hla Typing Market Size Share by Region
Table 2020-2025 Global Hla Typing Market Size by Application
Table 2020-2025 Global Hla Typing Market Share by Application
Table 2020-2025 Global Hla Typing Key Vendors Revenue
Figure 2020-2025 Global Hla Typing Market Size and Growth Rate
Table 2020-2025 Global Hla Typing Key Vendors Market Share
Table 2020-2025 Global Hla Typing Market Size by Type
Table 2020-2025 Global Hla Typing Market Share by Type
Table 2025-2030 Global Hla Typing Market Size by Region
Table 2025-2030 Global Hla Typing Market Size Share by Region
Table 2025-2030 Global Hla Typing Market Size by Application
Table 2025-2030 Global Hla Typing Market Share by Application
Table 2025-2030 Global Hla Typing Key Vendors Revenue
Figure 2025-2030 Global Hla Typing Market Size and Growth Rate
Table 2025-2030 Global Hla Typing Key Vendors Market Share
Table 2025-2030 Global Hla Typing Market Size by Type
Table 2025-2030 Hla Typing Global Market Share by Type

Companies Mentioned

  • BD
  • Thermo Fisher Scientific
  • Bio-Rad Laboratories
  • Bruker
  • F. Hoffman-La Roche
  • Bag Diagnostics
  • Caredx
  • Creative Biolabs
  • Fujirebio Holdings
  • Gendx
  • Hologic
  • Histogenetics
  • Hansa Biopharma
  • lllumina
  • Inno-Train Diagnostik GmbH
  • Immucor
  • Krishgen Biosystems
  • Omixon
  • PacBio
  • Proimmune
  • TBG Diagnostics Limited
  • Takara Bio

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