Cementless Total Knee Systems Market Report 2025

The cementless total knee systems market size has grown strongly in recent years. It will grow from $4.44 billion in 2024 to $4.68 billion in 2025 at a compound annual growth rate (CAGR) of 5.6%. The growth during the historic period was driven by rising demand for durable implants among younger patients, increasing awareness of advanced orthopedic treatments, growing support for personalized and patient-specific implant solutions, and the expanding number of outpatient and ambulatory surgical centers.

The cementless total knee systems market size is expected to see strong growth in the next few years. It will grow to $5.77 billion in 2029 at a compound annual growth rate (CAGR) of 5.3%. The anticipated growth during the forecast period is driven by a greater focus on value-based healthcare, increased surgeon expertise and training in cementless techniques, heightened concerns over complications associated with cemented implants, a stronger emphasis on early patient mobility and reduced hospital stays, and expanding use of 3D printing and digital planning for customized solutions. Key trends expected include innovations in implant surface technology, adoption of robotic-assisted surgery, advancements in biomaterials and implant coatings, progress in patient-specific instrumentation, and the evolution of minimally invasive surgical methods.

The growing prevalence of orthopedic diseases is expected to drive the expansion of the cementless total knee systems market. Orthopedic diseases affect the musculoskeletal system, including bones, joints, muscles, ligaments, and tendons, and often lead to pain, limited mobility, and reduced function. As populations age, more individuals are seeking long-lasting mobility solutions that alleviate joint pain, enhance movement, and support active lifestyles without the need for frequent medical interventions. Cementless total knee systems offer a durable and biologically integrated approach by promoting natural bone growth, reducing the risk of implant loosening, and restoring joint functionality without relying on bone cement. For example, in January 2024, the Office for Health Improvement & Disparities in the UK reported that the proportion of individuals aged 16 and older with a long-term musculoskeletal disease rose from 17.6% in 2022 to 18.4% in 2023. This trend highlights the rising need for effective joint replacement options, contributing to the market's growth.

Companies in the cementless total knee systems market are focusing on technological innovations such as TIDAL technology to improve implant performance and longevity. TIDAL technology involves an advanced 3D-printed porous design that enhances bone integration by improving mechanical strength, resistance to fatigue, and load distribution, which contributes to the long-term stability of implants. In April 2025, Restor3d Inc., a U.S.-based medical device manufacturer, received FDA 510(k) clearance for its iTotal Identity CR 3DP porous total knee system. This was the company’s first cementless, patient-specific implant. The system combines advanced 3D printing and porous surface technology to enhance bone integration and implant stability, while its customized design, tailored surgical instruments, and pre-navigated surgical features allow for increased surgical precision and efficiency.

In September 2023, Restor3d Inc. acquired ConforMIS Inc. for an undisclosed amount. With this acquisition, Restor3d seeks to broaden its lineup of patient-specific orthopedic implants by incorporating ConforMIS’ expertise in personalized knee replacement technology. This move also aims to accelerate advancements in 3D-printed cementless implant solutions. ConforMIS Inc. is a U.S.-based medical technology company specializing in cementless total knee implant systems.

Major players in the cementless total knee systems market are Johnson & Johnson Services Inc., Stryker Corporation, Zimmer Biomet Holdings Inc., Smith & Nephew plc, Enovis Corporation, Globus Medical Inc., MicroPort Scientific Corporation, Medacta International SA, B. Braun Melsungen AG, Waldemar Link GmbH & Co. KG, restor3d Inc., implantcast GmbH, United Orthopedic Corporation, Signature Orthopaedics Pty Ltd, Gruppo Bioimpianti Srl, Permedica S.P.A., Evolutis SAS, Euromed Implants GmbH, X.NOV SAS, and Beijing Chunli Zhongke Bio-Tech Co. Ltd.

North America was the largest region in the cementless total knee systems market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in cementless total knee systems report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the cementless total knee systems market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The cementless total knee systems market consists of sales of cruciate-retaining designs, mobile-bearing systems, cobalt-chromium alloys, patellar components, polyethylene inserts, and porous-coated implants. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The fast surge in U.S. tariffs and the trade tensions that followed in spring 2025 are heavily affecting the medical equipment sector, particularly for imported imaging machine components, surgical-grade stainless steel, and plastic disposables. Hospitals and clinics resist price hikes, pressuring manufacturers’ margins. Regulatory hurdles compound the problem, as tariff-related supplier changes often require re-certification of devices, delaying time-to-market. Companies are mitigating risks by dual-sourcing critical parts, expanding domestic production of commoditized items, and accelerating R&D in cost-efficient materials.

The cementless total knee systems market research report is one of a series of new reports that provides cementless total knee systems market statistics, including the cementless total knee systems industry global market size, regional shares, competitors with the cementless total knee systems market share, detailed cementless total knee systems market segments, market trends, and opportunities, and any further data you may need to thrive in the cementless total knee systems industry. This cementless total knee systems market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

A cementless total knee system is a type of knee implant designed to secure fixation without the use of bone cement, instead depending on natural bone growth into the implant surface for long-term stability. It is used in total knee replacement procedures to restore damaged joint surfaces, promoting biological fixation as the bone integrates with the implant.

The primary components of cementless total knee systems include tibial and femoral components. Tibial components are implanted into the upper portion of the shinbone to provide a strong foundation for the artificial knee joint. These systems utilize various fixation techniques, including primary fixation and hybrid fixation, and are employed across different healthcare settings such as hospitals, orthopedic centers, and other medical facilities.

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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