Cryo-Electron Microscopy Market Report 2025

The cryo-electron microscopy market size has grown rapidly in recent years. It will grow from $1.48 billion in 2024 to $1.69 billion in 2025 at a compound annual growth rate (CAGR) of 14%. Growth during the historic period can be linked to the rising need for high-resolution imaging in structural biology, improvements in electron microscopy equipment, an increase in infectious disease and virology research, expanding use in academic and research institutions, and the shortcomings of conventional microscopy techniques.

The cryo-electron microscopy market size is expected to see rapid growth in the next few years. It will grow to $2.84 billion in 2029 at a compound annual growth rate (CAGR) of 13.8%. Growth in the forecast period is expected to be driven by the expanding use of cryo-EM technology in drug discovery, increased funding for life sciences and biotechnology research, advancements in automation and image processing, enhanced structural insights, and broader adoption in clinical diagnostics. Key trends during this period include the integration of artificial intelligence with cryo-EM, the miniaturization and portability of cryo-EM systems, a move toward cloud-based data analysis platforms, improvements in high-resolution imaging, and the development of hybrid imaging technologies.

The growth of the cryo-electron microscopy market is expected to be driven by the rising prevalence of infectious diseases in the coming years. Infectious diseases are illnesses caused by pathogenic microorganisms such as bacteria, viruses, fungi, or parasites, including diseases like malaria that can spread either directly or indirectly. The increase in infectious disease cases is attributed to rapid urbanization, which results in higher population densities and closer human contact, facilitating the transmission of infections. Cryo-electron microscopy aids infectious disease research by providing high-resolution images of viruses, bacteria, and host-pathogen interactions in near-native states. This technology helps quickly identify viral structures, understand infection mechanisms, and speed up the development of antivirals and vaccines. For example, in November 2023, the World Health Organization, a Switzerland-based intergovernmental organization, reported that malaria cases worldwide reached an estimated 249 million in 2022, marking a 2% increase of 5 million cases compared to 2021. Hence, the rising prevalence of infectious diseases is propelling the cryo-electron microscopy market.

Companies in the cryo-electron microscopy market are emphasizing technological advancements such as artificial intelligence (AI)-integrated cryo-transmission electron microscope (cryo-TEM) systems to improve image processing, automate data collection, enhance resolution, and speed up the 3D reconstruction of biomolecular structures. AI-integrated cryo-TEM systems combine artificial intelligence with high-resolution optics to optimize sample targeting, reduce variability from users, and accelerate data acquisition. For instance, in April 2025, Thermo Fisher Scientific, a US-based provider of scientific instruments and laboratory equipment, introduced the Thermo Scientific Krios 5 Cryo-TEM, a next-generation atomic-resolution platform. This system offers advanced automated data collection, higher sample throughput, and high-resolution imaging capabilities, allowing researchers to visualize molecular and cellular structures with remarkable clarity. It also features improved stability and automation that reduce manual involvement and increase productivity for high-volume cryo-EM workflows.

In March 2025, Thermo Fisher Scientific Inc., a US-based scientific solutions company, partnered with the Chan Zuckerberg Institute for Advanced Biological Imaging. The collaboration aims to advance cryo-electron microscopy (cryo-EM) technology by combining Thermo Fisher’s expertise in electron microscopy systems with the Chan Zuckerberg Imaging Institute’s advanced imaging research and laser phase plate innovation. The Chan Zuckerberg Institute for Advanced Biological Imaging is a US-based organization focused on developing breakthrough imaging tools to deepen the understanding of human biology and disease.

Major players in the cryo-electron microscopy market are Hitachi High-Tech Corporation, Thermo Fisher Scientific Inc., Danaher Corporation, Charles River Laboratories International Inc., Intertek Group plc, Bruker Corporation, Carl Zeiss AG, Japan Electron Optics Laboratory Ltd., Leica Microsystems GmbH, Gatan Inc., Oxford Instruments plc, Rigaku Corporation, TESCAN ORSAY HOLDING a.s., Nanoscience Instruments Inc., Protochips Inc., E.A. Fischione Instruments Inc., NanoImaging Services Inc., DENSsolutions B.V., Direct Electron LP, Hummingbird Scientific LLC.

North America was the largest region in the cryo-electron microscopy market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in cryo-electron microscopy report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the cryo-electron microscopy market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The cryo-electron microscopy market consists of revenues earned by entities by providing services such as sample preparation, cryo-grid preparation, data acquisition, image processing, 3D reconstruction, and structural analysis. The market value includes the value of related goods sold by the service provider or included within the service offering. Only goods and services traded between entities or sold to end consumers are included. The cryo-electron microscopy (Cryo-EM) market includes sales of cryo-electron microscopes, sample preparation systems, cryo-holders, detectors, and imaging software. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The fast surge in U.S. tariffs and the trade tensions that followed in spring 2025 are heavily affecting the medical equipment sector, particularly for imported imaging machine components, surgical-grade stainless steel, and plastic disposables. Hospitals and clinics resist price hikes, pressuring manufacturers’ margins. Regulatory hurdles compound the problem, as tariff-related supplier changes often require re-certification of devices, delaying time-to-market. Companies are mitigating risks by dual-sourcing critical parts, expanding domestic production of commoditized items, and accelerating R&D in cost-efficient materials.

The cryo-electron microscopy market research report is one of a series of new reports that provides cryo-electron microscopy market statistics, including cryo-electron microscopy industry global market size, regional shares, competitors with a cryo-electron microscopy market share, cryo-electron microscopy market segments, market trends and opportunities, and any further data you may need to thrive in the cryo-electron microscopy industry. This cryo-electron microscopy market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

Cryo-electron microscopy (Cryo-EM) is an advanced imaging method that enables the visualization of biological molecules in near-atomic detail. This technique involves rapidly freezing samples at very low temperatures to maintain their natural structure without requiring staining or crystallization. By capturing 3D images of complex biological macromolecules, Cryo-EM offers valuable insights into their functions, interactions, and mechanisms, making it an essential tool in structural biology and drug discovery.

The primary categories within cryo-electron microscopy include instruments, fully automated instruments, semi-automated instruments, software, and services. Instruments encompass the hardware and physical components used to capture, transfer, and analyze cryogenically preserved biological samples at high resolution. The nano formulations involved consist of lipid nanoparticle formulations (LNFs), metal oxide formulations, metal formulations, and others. These are applied across technologies such as electron crystallography, single particle analysis, and cryo-electron tomography. The technology serves diverse applications, including life science research, cancer studies, omics, pharmaceutical and biotech manufacturing, cell and gene therapy, vaccines, preclinical and clinical research, medical diagnostics, and pathology. End users include research labs, forensic and diagnostic labs, pharmaceutical and biotech companies, contract research organizations, and more.

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

This product will be delivered within 1-3 business days.