Dermal Regeneration Market Report 2025

The dermal regeneration market size has grown strongly in recent years. It will grow from $1.64 billion in 2024 to $1.79 billion in 2025 at a compound annual growth rate (CAGR) of 9.2%. The growth during the historical period can be attributed to rising demand for minimally invasive skin repair, increasing prevalence of chronic wounds, an expanding aging population, a higher incidence of diabetes and vascular diseases, and growing awareness of wound care.

The dermal regeneration market size is expected to see strong growth in the next few years. It will grow to $2.52 billion in 2029 at a compound annual growth rate (CAGR) of 8.9%. The anticipated growth during the forecast period can be attributed to the rising incidence of burn injuries, increased adoption of stem cell-based therapies, incorporation of nanotechnology in scaffolds, growing use of telemedicine for wound monitoring, and expanding cosmetic and aesthetic applications. Key trends expected in this period include advancements in bioengineered skin substitutes, development of smart wound-healing materials, integration of 3D bioprinting for skin layer regeneration, innovation in hydrogel-based dermal products, and the expansion of hybrid natural-synthetic grafts.

The rising number of burn injuries is expected to drive growth in the dermal regeneration market. Burn injuries, caused by heat, chemicals, electricity, radiation, or friction, are increasing due to the widespread use of unsafe cooking fuels and appliances such as open flames and poorly maintained stoves. These factors raise the risk of accidental fires and scalds, especially in densely populated and low-income households. Treating moderate to severe skin damage from burns requires advanced tissue repair and skin restoration technologies provided by dermal regeneration solutions. For example, in January 2024, the Consumer Product Safety Commission (CPSC), a US federal agency, reported 11 deaths linked to fireworks, mainly caused by misuse and device malfunctions. Approximately 14,700 people sustained fireworks-related injuries, representing a sharp increase of about 38% in fatalities and 52% in injuries compared to 2023. Consequently, the growing incidence of burn injuries is boosting the dermal regeneration market.

Leading companies in the dermal regeneration market are focusing on developing innovative products such as collagen-based dermal matrices, which offer biocompatibility and a low risk of immune rejection. A collagen-based dermal matrix consists primarily of collagen and acts as a supportive scaffold to promote skin tissue growth and healing. For instance, in January 2025, Fesarius Therapeutics Inc., a US biotechnology firm, announced that the US Food and Drug Administration (FDA) had granted 510(k) clearance for its DermiSphere hydrogel Dermal Regeneration Template (DermiSphere hDRT). This product represents a new generation of collagen-based dermal matrices designed to enhance tissue integration, revascularization, and wound healing. It is intended for use in advanced wound care, reconstructive surgery, and regenerative medicine, offering a promising advancement in dermal regeneration.

In August 2023, Coloplast, a Denmark-based medical device company, acquired Kerecis Limited for $1.3 billion. This acquisition allowed Coloplast to strengthen its biologic wound care and dermal regeneration portfolio by incorporating Kerecis’s innovative fish-skin graft technology. Kerecis Limited is a US-based producer of dermal regeneration products.

Major players in the dermal regeneration market are Stryker Corp., Smith & Nephew Plc, Coloplast Corp., Integra LifeSciences Corp., Organogenesis Inc., MiMedx Group Inc., Krystal Biotech Inc., Amryt Pharma plc, Regenity Biosciences Inc., Avita Medical Inc., HANS BIOMED Corporation, Polynovo, Symatese Co., Gunze Co Ltd., Castle Creek Biosciences Inc., Stratatech, MedSkin Solutions Dr. Suwelack AG, Japan Tissue Engineering Co. Ltd., Fesarius Therapeutics Inc., CollPlant Biotechnologies Ltd., Abeona Therapeutics Inc., Holostem Terapie Avanzate, Extrimity Care LLC.

North America was the largest region in the dermal regeneration market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in dermal regeneration report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the dermal regeneration market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The dermal regeneration market consists of revenues earned by entities by providing services such as custom regeneration planning, post-treatment monitoring, tissue engineering collaboration services, and clinical data management. The market value includes the value of related goods sold by the service provider or included within the service offering. The dermal regeneration market also includes sales of collagen-based dressings, hydrogel dressings, antimicrobial dressings, and silicone sheets. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sudden escalation of U.S. tariffs and the consequent trade frictions in spring 2025 are severely impacting the pharmaceutical companies contend with tariffs on APIs, glass vials, and lab equipment inputs with few alternative sources. Generic drug makers, operating on razor-thin margins, are especially vulnerable, with some reducing production of low-profit medicines. Biotech firms face delays in clinical trials due to tariff-related shortages of specialized reagents. In response, the industry is expanding API production in India and Europe, increasing inventory stockpiles, and pushing for trade exemptions for essential medicines.

The dermal regeneration Market Research Report is one of a series of new reports that provides dermal regeneration market statistics, including dermal regeneration industry global market size, regional shares, competitors with a dermal regeneration market share, detailed dermal regeneration market segments, market trends and opportunities, and any further data you may need to thrive in the dermal regeneration industry. The dermal regeneration market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

Dermal regeneration refers to the process of repairing and rebuilding the dermis - the deeper skin layer - after damage caused by injury, burns, or surgery. This process involves restoring skin cells, blood vessels, and connective tissue to regain the skin’s normal structure and function. Specialized therapies often aid dermal regeneration by providing a framework that promotes new tissue growth, accelerating healing, reducing scarring, and enhancing both the appearance and functionality of the skin.

The primary product types used in dermal regeneration include skin substitutes, scaffolds, and others. Skin substitutes are medical products designed to replace or support damaged skin and are commonly applied in treating burns, wounds, or facilitating post-surgical recovery. Key technologies involved include tissue engineering, cell-based therapies, biomaterial-based treatments, among others, utilizing materials such as bovine collagen, silicone, and shark cartilage. These products are used for applications like chronic wounds, burn injuries, acute wounds, plastic and reconstructive surgery, and more, serving a variety of end-users including hospitals, dermatology and aesthetic clinics, specialty clinics, ambulatory surgical centers (ASCs), and others.

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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